Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise
Test-retest Reliability of Lung Diffusing Capacity for Nitric Oxide During Light and Moderate Intensity Cycling Exercise
1 other identifier
observational
17
1 country
1
Brief Summary
This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Oct 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 19, 2020
CompletedFirst Submitted
Initial submission to the registry
October 28, 2020
CompletedFirst Posted
Study publicly available on registry
November 5, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2021
CompletedApril 19, 2021
April 1, 2021
2 months
October 28, 2020
April 15, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Diffusing capacity for nitric oxide (DLNO)
DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.
At second study visit
Diffusing capacity for nitric oxide (DLNO)
DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.
At third study visit, approximately 1-2 weeks after second study visit
Secondary Outcomes (14)
Diffusing capacity for nitric oxide (DLNO)
At second study visit
Diffusing capacity for nitric oxide (DLNO)
At third study visit, approximately 1-2 weeks after second study visit
Diffusing capacity for carbon monoxide (DLCO)
At second study visit
Diffusing capacity for carbon monoxide (DLCO)
At third study visit, approximately 1-2 weeks after second study visit
Diffusing capacity for carbon monoxide (DLCO)
At second study visit
- +9 more secondary outcomes
Eligibility Criteria
Healthy people without chronic cardiopulmonary diseases will be invited to participate in this study.
You may qualify if:
- Healthy
- Age 18 yrs and older
- Ability to follow study procedures and instructions in German
You may not qualify if:
- Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc)
- Obesity (BMI \> 30kg/m2)
- Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination)
- Mental impairment leading to inability to cooperate
- Respiratory infection in the last two weeks
- Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio \< lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Thomas Radtkelead
Study Sites (1)
University of Zurich and University Hospital of Zurich
Zurich, 8001, Switzerland
Study Officials
- PRINCIPAL INVESTIGATOR
Thomas Radtke, PhD
University of Zurich and University Hospital Zurich
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- PD Dr phil Thomas Radtke
Study Record Dates
First Submitted
October 28, 2020
First Posted
November 5, 2020
Study Start
October 19, 2020
Primary Completion
December 31, 2020
Study Completion
January 1, 2021
Last Updated
April 19, 2021
Record last verified: 2021-04