Effects of Combined Interventions to Optimize Recovery During High-intensity Exercises in Healthy Adults

NCT04508738 | Completed

• 1 other identifier: ERP_2020
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

The objective of the study is to evaluate the effects a complex recovery intervention during the breaks of a repeated sprint test on exercise performance compared to placebo and control conditions. The enhanced recovery package (ERP) includes neck cooling with an iced gel pad, drinking a 6% CHO solution, mouth-rinsing with a 10% CHO, 6 mg･kg -1 caffeine solution, performing submaximal squats and hyperventilating a hyperoxic mixture; all applied in each 3-min break in-between the six 30-s sprints. This intervention will be compared to a placebo and a control condition.

Conditions

Healthy

Outcome Measures

Primary Outcomes (2)

• Change in mean power output

  Measured over the six 30s high-intensity cycling sprints in each of the three conditions. Mean power mirrors the body's ability to generate muscle power and physical energy. Any meaningful effects of the recovery interventions will eventually translate into a higher power output.

  through study completion, an expected average of 3 weeks per participant

• Change in fatigue index

  Fatigue index = drop in power output from the beginning to the end a 30s sprint test. The change in this index will be calculated from the 1st to the 6th sprint test in each condition.

  through study completion, an expected average of 3 weeks per participant

Study Arms (3)

ERP Intervention

EXPERIMENTAL

Combination of different methods to improve recovery.

Other: ERP

Control

NO INTERVENTION

Passive recovery by sitting on a chair

Placebo

PLACEBO COMPARATOR

A combination of methods similar to the ERP intervention but at an intensity / mixture supposed to be ineffective at improving recovery.

Other: Placebo

Interventions

ERP OTHER

The ERP intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants. ERP: 1) neck cooling with an iced gel pad, 2) drinking a ∼ 6% CHO solution, 3) mouth-rinsing with a ∼10% CHO, ∼6 mg ･ kg -1 caffeine solution, 4) performing submaximal squats and 5) hyperventilating a hyperoxic mixture

ERP Intervention

Placebo OTHER

The control intervention is applied in a randomized and counter-balanced order across visits 2-4 in each 3-min break in-between the six 30-s sprints, with one intervention per visit. The order and timing of the constituents of the interventions will be strictly constant within and between participants. 1\) neck "cooling" with room temperature gel pack, 2) drinking an artificially sweetened solution, 3) mouth-rinsing with artificially sweetened solution (containing no caffeine), 4) performing unloaded squat manoeuvres, 5) deep breaths with room air

Placebo

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Informed Consent as documented by signature (Appendix Informed Consent Form)
• Healthy
• Male
• Age: 18-40 years
• Body-Mass-Index (BMI): 18.5-24.9 kg･m-2
• Trained individuals: max. Power output ≥ 4.0 Watts･kg-1
• Non-smoking
• Willingness to adhere to the study rules

You may not qualify if:

• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participants
• Previous enrolment into the current study
• Intake of medications affecting performance or the respiratory, cardiovascular or neuromuscular system
• Acute or chronic illness affecting performance or the respiratory, cardiovascular or neuromuscular system

Sponsors & Collaborators

• Swiss Federal Institute of Technology: lead

Study Sites (1)

ETH Zürich, Exercise Physiology Lab

Zurich, Canton of Zurich, 8057, Switzerland

Location

Study Officials

• Christina M. Spengler, Prof.

  Christina M. Spengler, Prof. Study Principal Investigator Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Participants will be blinded about the true nature of the placebo intervention
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Each participant will be tested on 4 different days with a control, a placebo and an interventional condition in random order.

Study Record Dates

• First Submitted: August 4, 2020
• First Posted: August 11, 2020
• Study Start: September 10, 2020
• Primary Completion: June 30, 2021
• Study Completion: June 30, 2021
• Last Updated: July 2, 2021

Record last verified: 2020-10

Locations

CH (1)