Lung Cancer Risk and Early Detection in Firefighters
1 other identifier
interventional
734
1 country
1
Brief Summary
This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable lung-cancer
Started Mar 2021
Longer than P75 for not_applicable lung-cancer
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 28, 2020
CompletedFirst Posted
Study publicly available on registry
November 3, 2020
CompletedStudy Start
First participant enrolled
March 2, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2025
CompletedNovember 24, 2025
November 1, 2025
4.7 years
October 28, 2020
November 20, 2025
Conditions
Outcome Measures
Primary Outcomes (2)
Nodule detection rate
Frequency of nodule detection
12 months
High-risk nodule detection rate
Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious
12 months
Secondary Outcomes (2)
Interstitial lung disease detection rate
12 months
Coronary artery calcification (CAC) ordinal scores
12 months
Study Arms (1)
Low-Dose CT
EXPERIMENTALLow Dose CT Scan of the Chest
Interventions
All participants will have a low dose chest CT either within one year of enrollment or after enrollment
Eligibility Criteria
You may qualify if:
- years of age or with 10 years of firefighting experience
- Current or retired firefighters
- No personal history of lung cancer
- Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study
You may not qualify if:
- Any active cancer (undergoing treatment or diagnosed within the past 5 years)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Erica T Warner, ScD
Massachusetts General Hospital
- PRINCIPAL INVESTIGATOR
Lecia V Sequist, MD
Massachusetts General Hospital
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- SCREENING
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor of Medicine
Study Record Dates
First Submitted
October 28, 2020
First Posted
November 3, 2020
Study Start
March 2, 2021
Primary Completion
November 1, 2025
Study Completion
November 1, 2025
Last Updated
November 24, 2025
Record last verified: 2025-11
Data Sharing
- IPD Sharing
- Will not share