Efficacy of Topical Heparin Spray on Donor Site Wound Healing Time Compared to Conventional Dressing Among Patients Undergoing Split Thickness Skin Grafting

NCT04613336 | Unknown

• 1 other identifier: dow123
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Wound is defined by the breach in dermis of the skin. It can be caused by road traffic accidents, tumor excision, chronic illness like diabetes, bed sores in bedridden patients, burns, insects' bites etc. Treatment goals for wound coverage includes earliest debridement, dressings, local antibiotics, limb elevation, fracture fixations and wound coverage. Skin graft functions both as occlusive dressing, as a skin replacement and as a stimulus for healing. Even though the usage of flaps to cover the wounds has been increased recently still skin grafting serves as an easiest and simplest way of covering the wound. However, skin grafting introduces another wound in addition to the existing wound, the donor site wound (DSW). A secondary donor-site wound (DSW) is formed after harvesting split thickness skin graft which adds up with the primary wound to increase the total size of the wounds for the healing process. This donor site wound cause itching, pain and cosmetic embarrassment. That is why the proper and timely healing of the donor site wound is of great importance. Basic management of DSWs includes conventional dressings that provides absorption of bleeding solely.

Conditions

Wound Healing

Outcome Measures

Primary Outcomes (1)

• decrease in size of wound and decrease in surrounding skin edema

  3 months

Eligibility Criteria

• Age: 15 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

general public

You may qualify if:

• age between 18 to 55 years
• both genders
• non hypertensive patients
• Hemoglobin levels more than 10 g/dl
• Platelet count above 150 to 400 × 109/L
• Wounds for more than 6 weeks
• Any size of wound greater then 10\*10 cm

You may not qualify if:

• Hypertensive patients,
• Bleeding tendencies (Disorder),
• Immune-compromised,
• Familial history of bleeding

Sponsors & Collaborators

• Dow University of Health Sciences: lead

Study Sites (1)

Dr. Faraz

Karachi, Sindh, 73500, Pakistan

Location

Related Publications (1)

• Adil F, Memon MA, Khan FAA, Awan A, Siddiqui SU, Piprani FZ, Zareen K. Efficacy of topical heparin spray on donor site wound healing after split thickness skin grafting. Sci Rep. 2025 Jul 30;15(1):27814. doi: 10.1038/s41598-025-95437-5.

  PMID: 40738969 DERIVED

Study Officials

• dr.faisal akhlaque

  dow university

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: October 16, 2020
• First Posted: November 3, 2020
• Study Start: September 30, 2020
• Primary Completion: January 1, 2021
• Study Completion: February 1, 2021
• Last Updated: November 3, 2020

Record last verified: 2020-11

Locations

PA (1)