Evaluation of Small Vessel Disease by 3D-rotational Angiography

NCT04611906 | Completed

• 1 other identifier: Crec 2020.386
• Study Type: observational
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study is aimed to elucidate the factors affecting the remodeling process of arteriolosclerosis under current practice recommendations. Such knowledge may improve the understanding of cerebral small vessel disease (cSVD) mechanism, define pharmacological therapy and suggest treatment target.

Conditions

Stroke, Acute; Stroke; Small Vessel Cerebrovascular Disease; Ischemic Stroke

Keywords

stroke; small vessel disease; 3D-rotational Angiography; Ischemic stroke

Outcome Measures

Primary Outcomes (1)

• Morphological change

  The pre and post imaging in ischemic stroke patients by 3D-rotational angiography

  one year after recruitment

Study Arms (1)

Stroke patient

Patients who have acute cerebral ischemic symptoms attributed by cSVD can be recruited into this study. Eligible patients will be screened by Neurologists based on the inclusion and exclusion criteria. The time window for recruitment of the patient is 4 weeks from the qualifying stroke.

Eligibility Criteria

• Age: 30 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All ischemic stroke patients who have admitted to the Prince of Wales Hospital will be screened.

You may qualify if:

• Patient is Chinese ONLY
• Patient is 30 to 85 years of age, inclusive.
• Patients who have an acute lacunar infarct in diffusion-weighted MRI compatible with small vessel disease in territories supplied by the lateral lenticulostriate arteries without relevant intracranial atherosclerotic stenosis ≥60%.
• Patient who has no contra-indication for the proposed imaging tests.
• Patient who understands the purpose and requirements of the study, and has an informed consent.
• Patient who has Modified Functional Ambulation Classification 4 or above.

You may not qualify if:

• Stroke etiology uncertain or unrelated to small vessel disease, such as cardioembolism, Moyamoya disease, ICAD or primary angiitis of CNS.
• Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
• A medical condition that would not allow the patient to adhere to the protocol or complete the study.
• Patients with severe renal impairment.
• Patients who are taking warfarin and non-vitamin K antagonist oral anticoagulants would also be excluded.

Sponsors & Collaborators

• Chinese University of Hong Kong: lead

Study Sites (1)

Chinese University of Hong Kong

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Stroke; Cerebral Small Vessel Diseases; Ischemic Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Yiu Ming Bonaventure IP, MBChB, MRCP

  Chinese University of Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist resident

Study Record Dates

• First Submitted: October 27, 2020
• First Posted: November 2, 2020
• Study Start: November 5, 2020
• Primary Completion: June 30, 2025
• Study Completion: June 30, 2025
• Last Updated: February 24, 2026

Record last verified: 2026-02

Data Sharing

• IPD Sharing: Will not share

Locations

HK (1)