Tahini, Antioxidant Status and Endothelial Function

NCT04608747 | Completed

• 1 other identifier: 703
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Cardiovascular disease (CVD), a cluster of disorders that affect heart and blood vessels, is the leading cause of morbidity and mortality around the world and is responsible for 17.9 million deaths annually worldwide. CVD risk factors can be modifiable (nutrition, physical activity, obesity, smoking, hyperlipidemia, hypertension and diabetes) and non-modifiable (age, gender, ethnicity, family history and socioeconomic status). Chronic exposure to CVD risk factors induces oxidative stress and promotes inflammation. In addition, endothelial cells in response to the inflammatory reaction secrete growth factors, leading to the destruction of vascular endothelium and promoting atherogenesis. Oxidative stress refers to the imbalance between anti-oxidant and pro-oxidant compounds, with predominance of the pro-oxidant ones. Reactive Oxygen Species overproduction has been implicated in pathogenesis and complications of numerous diseases including diabetes, cardiovascular diseases, cancer, neurodegenerative diseases and chronic kidney disease. Moreover, endothelium consists of a single layer of endothelial cells; it is the natural barrier between blood and tissues and also an endocrine organ. It plays a key role in vascular homeostasis by maintaining a balance between vasodilation and vasoconstriction and is responsible for fluid filtration, blood vessel tone, hormone trafficking, hemostasis, regulation of blood flow and growth of blood vessels. Thus, reductions in endothelial function are detrimental and predict and precede the development of overt CVD. Sesame belongs to Pedaliaceae family and can be consumed in different forms such as seeds, oil or tahini, i.e., a 100 % peeled, ground and roasted sesame paste. Sesame seeds are rich in polyunsaturated fatty acids, proteins, vitamin E and lignans, such as sesamin, sesamolin and sesamol. Recent studies have highlighted the antioxidant, antihypertensive, hypolipidemic and appetite control properties of sesame seeds and sesame oil. Regarding the consumption of tahini and its effect on human health, only three studies are available in the current literature, one of them in patients with type 2 diabetes, one in diabetic animal model and one in Alzheimer's disease animal model. Thus, the aim of the present study is to investigate the effect of tahini consumption on oxidative stress, blood pressure, endothelial function and arterial stiffness in healthy males postprandially.

Conditions

Oxidative Stress; Endothelial Function; Blood Pressure; Arterial Stiffness; Blood Glucose

Keywords

tahini; sesame; antioxidants; postprandial

Outcome Measures

Primary Outcomes (1)

• Concentration of oxidative stress biomarkers

  concentration of urinary 8-iso-prostaglandin F2a

  Four hours after tahini consumption

Study Arms (1)

Intervention arm

EXPERIMENTAL

After an overnight fast, participants subjected to baseline measurements and blood and urine collection and then consumed an amount of 50 g of tahini. Blood and urine collection and other measurements were repeated 4 h postprandially.

Other: Tahini

Interventions

Tahini OTHER

Fifty grams of tahini were consumed by 20 healthy males

Intervention arm

Eligibility Criteria

• Age: 20 Years - 40 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• age between 20 and 40 years
• Body Mass Index (BMI)\<30 kg/m2

You may not qualify if:

• alcohol or drug abuse,
• any medication or vitamin/mineral supplementation
• alternative diet (vegetarian, macrobiotic, etc.)
• recent use of antibiotics
• history of any chronic disease

Sponsors & Collaborators

• Harokopio University: lead

Study Sites (1)

Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital

Athens, 11527, Greece

Location

Related Publications (23)

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  BACKGROUND

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  BACKGROUND

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MeSH Terms

Conditions

SeSAME syndrome

Study Officials

• NIKOLAOS K TENTOLOURIS, PROF

  Diabetes CeMedical School, National and Kapodistrian University of Athens, Laiko General Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: POSTDOCTORAL RESEARCHER

Study Record Dates

• First Submitted: October 25, 2020
• First Posted: October 29, 2020
• Study Start: January 2, 2020
• Primary Completion: July 31, 2020
• Study Completion: July 31, 2020
• Last Updated: October 30, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

GR (1)