3D Analysis of Cemento-Osseous Lesions

NCT04608708 | Completed

• 1 other identifier: 2020/189
• Study Type: observational
• Target: 46
• Locations: 1 country
• Sites: 1

Brief Summary

COD lesions effect a wide range of different anatomical areas, show different volume and morphometric characteristics.

Conditions

Bone Diseases; Cone-beam Computed Tomography; Florid Cemento-osseous Dysplasia

Keywords

Bone Diseases; Cone-beam computed tomography; Florid cemento-osseous dysplasia

Outcome Measures

Primary Outcomes (4)

• the correlation between presence of cemento osseous dysplasia and gender/ age

  It usually affects female and black patients. Most of the patients are initially diagnosed between the ages of 30 and 50, and the diagnosis is almost never made in individuals younger than 20

  for three months from the beginning of the study

• cemento osseous dysplasia lesion's location and relationship with the anatomical structures

  If the lesions were in association with the teeth, the teeth numbers were recorded. The periphery of the lesions was divided into two sections: well-defined (corticated, sclerotic, non-corticated and partially corticated) and ill-defined (perforating, diffuse and invasive). The shape of the lesion was classified as circular, oval or irregular. The presence of a hypodense capsule was assessed as present, absent or partially present. The involvement with the adjacent structures - cortical bone (lingual and buccal), mandibular canal, mental foramen, nasopalatinal canal, incisive foramen, maxillary sinus, nasal fossa and anterior mandibular canal - was assessed and recorded. The effects on the cortical bone were assessed as intact, thinning, expansion and thinning, thinning and perforation, expansion, thinning and perforation or perforation. The internal calcified parts of the lesions.

  for three months from the beginning of the study

• cemento osseous dysplasia lesions dimensional measurement of the lesions

  The internal calcified parts of the lesions and the total volume of the lesions were also assessed. The greatest linear dimension of the buccolingual, buccopalatinal and mesiodistal positions was measured on the axial plane, while the supero-inferior dimension was measured on sagittal or cross-sectional images.

  for three months from the beginning of the study

• cemento osseous dysplasia lesions volume of the lesions

  The internal calcified parts of the lesions and the total volume of the lesions were also assessed.

  for three months from the beginning of the study

Study Arms (3)

Group 1. Periapical Cemento-Osseous Dysplasia

In Periapical Cemento-Osseous Dysplasia , the lower anterior teeth are usually affected. In these lesions, normal bone is replaced by fibrous tissue that contains amorphous vascularised calcifications. In the early stage, it can mimic a periapical lesion, but it is usually associated with vital teeth, without any clinical complaint, and it requires no intervention. Histopathologically, the lesion is similar to fibrous dysplasia and ossifying fibroma.

Other: The data of patients who had applied to the clinic for various reasons and were diagnosed with fibro-osseous lesions

Group 2. Focal Cemento-Osseous Dysplasia

It occurs in a single area of the posterior teeth. Its radiographic and histolopathological features are similar to Periapical Cemento-Osseous Dysplasia

Other: The data of patients who had applied to the clinic for various reasons and were diagnosed with fibro-osseous lesions

Grup 3. Florid Cemento-Osseous Dysplasia

When the lesions involve two or more quadrants of the jaw, it is defined as Florid Cemento-Osseous Dysplasia. Its radiographic and histolopathological features are similar to Periapical Cemento-Osseous Dysplasia

Other: The data of patients who had applied to the clinic for various reasons and were diagnosed with fibro-osseous lesions

Interventions

The data of patients who had applied to the clinic for various reasons and were diagnosed with fibro-osseous lesions OTHER

lesions diagnosed radiologically and followed up for at least one year were included in this study with the help of cone beam computed tomography.

Group 1. Periapical Cemento-Osseous Dysplasia; Group 2. Focal Cemento-Osseous Dysplasia; Grup 3. Florid Cemento-Osseous Dysplasia

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

diagnosed with fibro-osseous lesions with the help of cone beam computed tomography between 2017 and 2020 were included in the study

You may qualify if:

• They were diagnosed with fibro-osseous lesions with the help of cone beam computed tomography between 2017 and 2020 were included in the study.
• The lesions diagnosed radiologically and followed up for at least one year were included in this study.

You may not qualify if:

• Radiographs with insufficient diagnostic images were not included.

Sponsors & Collaborators

• Recep Tayyip Erdogan University Training and Research Hospital: lead

Study Sites (1)

Recep Tayyip Erdogan University Training and Research Hospital

Rize, 53100, Turkey (Türkiye)

Location

Related Publications (2)

• Kato CNAO, Barra SG, Amaral TMP, Silva TA, Abreu LG, Brasileiro CB, Mesquita RA. Cone-beam computed tomography analysis of cemento-osseous dysplasia-induced changes in adjacent structures in a Brazilian population. Clin Oral Investig. 2020 Aug;24(8):2899-2908. doi: 10.1007/s00784-019-03154-x. Epub 2020 Feb 19.

  PMID: 32076867 BACKGROUND

• Kato CN, Barra SG, Pereira MJ, Gomes LT, Amaral TM, Abreu LG, Brasileiro CB, Mesquita RA. Mandibular radiomorphometric parameters of women with cemento-osseous dysplasia. Dentomaxillofac Radiol. 2020 May 1;49(4):20190359. doi: 10.1259/dmfr.20190359. Epub 2019 Dec 20.

  PMID: 31846355 BACKGROUND

MeSH Terms

Conditions

Bone Diseases; Florid cemento-osseous dysplasia

Condition Hierarchy (Ancestors)

Musculoskeletal Diseases

Study Officials

• Dilara Nil Günaçar

  Recep Tayyip Erdogan University Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: October 21, 2020
• First Posted: October 29, 2020
• Study Start: October 22, 2019
• Primary Completion: March 10, 2020
• Study Completion: October 21, 2020
• Last Updated: October 29, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: Data will be available 5 years after publication
• Access Criteria: Data access requests will be reviewed by authors.

Locations

TU (1)