Stress Cardiac MRI in Ischemic Patients
Assessment of Myocardial Viability by Cardiac Magnetic Resonance Feature Tracking at Rest and During Stress by Low Dose Dobutamine
1 other identifier
observational
50
0 countries
N/A
Brief Summary
The aim of this study is to assess the diagnostic accuracy of CMR feature-tracking (FT) at rest \& during stress with low dose dobutamine (LDD) in the evaluation of viability in ischemic cardiomyopathy (ICM) patients and compare it with delayed gadolinium enhancement (DGE).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Nov 2021
Shorter than P25 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 9, 2020
CompletedFirst Posted
Study publicly available on registry
October 19, 2020
CompletedStudy Start
First participant enrolled
November 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2022
CompletedOctober 19, 2020
October 1, 2020
1 month
October 9, 2020
October 9, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
comparison of myocardial strain with late gadolinium enhancement
analysis of the myocardial strain by low dose dobutamine and test if it can assess myocardial viability
Baseline
Interventions
the patients will underwent dobutamine stress cardiac MRI
Eligibility Criteria
50 patients with chronic LV systolic dysfunction due to coronary artery disease (CAD)
You may qualify if:
- All patients recruited into the study have chronic LV systolic dysfunction due to coronary artery disease (CAD)
You may not qualify if:
- All patients with a contraindication to MR study:
- Patients with implanted non-MRI compatible electronic devices (e.g. Cardiac pacemakers, intracranial metallic clips, implanted hearing aids, etc.)
- Patients with foreign bodies in the eye.
- Claustrophobic patients.
- Patients diagnosed with recent acute coronary syndrome within 4 weeks.
- Patients who had contraindications for MRI or contrast agents, and those with poor image quality due to either inadequate breath holding or arrhythmias
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Bhutani M, Vatsa D, Rahatekar P, Verma D, Nath RK, Pandit N. Role of strain imaging for assessment of myocardial viability in symptomatic myocardial infarction with single vessel disease: An observational study. Echocardiography. 2020 Jan;37(1):55-61. doi: 10.1111/echo.14567. Epub 2019 Dec 23.
PMID: 31868950BACKGROUNDSchuster A, Paul M, Bettencourt N, Morton G, Chiribiri A, Ishida M, Hussain S, Jogiya R, Kutty S, Bigalke B, Perera D, Nagel E. Cardiovascular magnetic resonance myocardial feature tracking for quantitative viability assessment in ischemic cardiomyopathy. Int J Cardiol. 2013 Jun 20;166(2):413-20. doi: 10.1016/j.ijcard.2011.10.137. Epub 2011 Nov 29.
PMID: 22130224BACKGROUND
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
October 9, 2020
First Posted
October 19, 2020
Study Start
November 1, 2021
Primary Completion
December 1, 2021
Study Completion
June 1, 2022
Last Updated
October 19, 2020
Record last verified: 2020-10