Tobacco and Nicotine Consumption and the Risk of Acquisition of Coronavirus Disease 2019 (COVID-19)

NCT04583761 | Completed

• 1 other identifier: APHP200663
• Study Type: observational
• Target: 622
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this case-control study is to assess the association of the current and former consumption of tobacco and nicotine in the risk of acquisition of severe acute respiratory syndrome 2 (SARS-CoV-2). the investigators will send a structured interview by mail regarding use of tobacco and nicotine to 2500 healthcare workers (1250 cases with a positive Real Time Polymorphism Chain Reaction (RT-PCR) and 1250 controls with a negative PCR) who were tested in Paris for in March and April, 2020. OR will be estimated by conditional logistic regression modelling with matching for sex and age.

Conditions

COVID-19

Outcome Measures

Primary Outcomes (1)

• questionnaire to assess strength of correlation between current smoking and SARS-CoV-2 RT-PCR positivity

  No intervention

  30 minutes

Secondary Outcomes (3)

• questionnaire to assess strength of correlation between current alternative nicotine delivery systems and SARS-CoV-2 RT-PCR positivity

  30 minutes

• questionnaire to assess strength of correlation between former smokers and SARS-CoV-2 RT-PCR positivity

  30 minutes

• questionnaire to assess strength of correlation between former alternative nicotine delivery systems and SARS-CoV-2 RT-PCR positivity

  30 minutes

Study Arms (2)

cases

Healthcare workers with mild symptoms of COVID-19 and a positive RT-PCR test for SARS-CoV-2

Behavioral: questionnaire

controls

Healthcare workers with mild symptoms of COVID-19 and a negative RT-PCR test for SARS-CoV-2

Behavioral: questionnaire

Interventions

questionnaire BEHAVIORAL

Mailed structured regarding current and former tobacco consumption and use of alternative nicotine delivery systems

cases; controls

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthcare workers tested for SARS-CoV-2 in Hotel Dieu Hospital in Paris in March, 2020

You may qualify if:

• Healthcare workers with mild symptoms of COVID-19 tested with RT-PCR in nasopharyngeal swabs:
• Cases : positive RT-PCR
• Controls : negative RT-PCR
• Informed consent obtained by e-mail.

You may not qualify if:

• no available e-mail address
• age \< 18
• no answer to the structured questionnaire

Sponsors & Collaborators

• Assistance Publique - Hôpitaux de Paris: lead
• URC-CIC Paris Descartes Necker Cochin: collaborator

Study Sites (1)

Hotel-Dieu Hospital

Paris, 75004, France

Location

MeSH Terms

Conditions

COVID-19

Interventions

Surveys and Questionnaires

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Data Collection; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 5, 2020
• First Posted: October 12, 2020
• Study Start: October 14, 2020
• Primary Completion: February 6, 2021
• Study Completion: February 6, 2021
• Last Updated: September 15, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)