Cerebral Hemodynamics During Early Verticalization After (Successful) Thrombectomy Poststroke

NCT04573114 | Unknown

• 1 other identifier: 2020-01732
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.

Conditions

Stroke; Healthy

Outcome Measures

Primary Outcomes (1)

• Blood flow velocity

  Cerebral blood flow velocity measured with transcranial doppler ultrasound

  within 12 hours post thrombectomy

Secondary Outcomes (6)

• Blood pressure

  within 12 hours post thrombectomy

• Heart rate

  within 12 hours post thrombectomy

• Oxygen saturation

  within 12 hours post thrombectomy

• Impairment caused by a stroke

  within 12 hours post thrombectomy

• Neurological status

  within 12 hours post thrombectomy

Other Outcomes (5)

• Reperfusion after thrombectomy

  within 12 hours post thrombectomy

• Perfusion imaging

  within 24 hours post thrombectomy

• Disability

  3 month post stroke

Study Arms (2)

Stroke subjects

Procedure: Verticalization

Healthy

Procedure: Verticalization

Interventions

Verticalization PROCEDURE

Progressive levels of verticalization

Healthy; Stroke subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

•First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)

You may qualify if:

• First-ever ischemic stroke in the territory of the middle cerebral artery (MCA)
• ≤12 hours after mechanical thrombectomy
• Conscious
• Hemodynamically stable
• years or older
• Informed consent of the patient and/ or legal representative

You may not qualify if:

• Verticalization not allowed according to treating physician
• Known pre-stroke disease affecting cerebral blood flow
• Temporal bone windows insufficient to enable ultrasound penetration
• Intubation anticipated or occurred
• Venous thromboembolism
• Symptomatic intracranial hemorrhage

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

University Hospital Zurich

Zurich, Canton of Zurich, 8091, Switzerland

RECRUITING

Related Publications (2)

• Deseoe J, Rottenberger Y, Pipping T, Schwarz A, Lehmann A, Veerbeek JM, Wegener S, Luft AR, Held JPO, Globas C. Very early tilt-table verticalization unmasks impaired cerebral autoregulation within 24 h after endovascular thrombectomy: a transcranial Doppler study. Front Neurol. 2026 Jan 6;16:1709991. doi: 10.3389/fneur.2025.1709991. eCollection 2025.

  PMID: 41567543 DERIVED

• Deseoe J, Schwarz A, Pipping T, Lehmann A, Veerbeek JM, Luft AR, Wegener S, Globas C, Held JPO. Cerebral blood flow velocity progressively decreases with increasing levels of verticalization in healthy adults. A cross-sectional study with an observational design. Front Neurol. 2023 Apr 17;14:1149673. doi: 10.3389/fneur.2023.1149673. eCollection 2023.

  PMID: 37139076 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Andreas Luft, MD

  University of Zurich

  STUDY CHAIR

Central Study Contacts

Jeremia Held, PhD

CONTACT

0442555645; jeremia.held@uzh.ch

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 3, 2020
• First Posted: October 5, 2020
• Study Start: September 2, 2020
• Primary Completion: December 31, 2022
• Study Completion: December 31, 2022
• Last Updated: November 29, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)