Ceramide Level as Apredictor of Outcomes in Patients of Anterior Myocardial Infarction Undergoing Primary Coronary Intervention

NCT04572191 | Unknown

• 1 other identifier: anterior STEMI
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Ceramide level as a predictor of outcomes in patients of anterior myocardial infarction undergoing primary Coronary intervention

Conditions

Anterior STEMI

Outcome Measures

Primary Outcomes (1)

• to detect early & mid -term MACE complication in anterior STEMI patients undergoing PPCI & their relation with ceramide level in these patients

  to detect early \& mid -term MACE complication in anterior STEMI patients undergoing PPCI \& their relation with ceramide level in these patients

  BASELINE

Interventions

CERAMIDE LEVEL IN BLOOD DIAGNOSTIC_TEST

BY ELISA ASSAY TO DETECT CERAMIDE LEVEL IN BLOOD IN ANTERIOR STEMI PATIENTS

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

ALL PATIENTS COMPLAING OF ANTERIOR STEMI \& UNDERENTPRIMARY PCI

You may qualify if:

• Subjects with anterior STEMI according to ESC guidelines 2017 . 2. Subjects undergoing PPCI

You may not qualify if:

• Patients with previous PCI. Patients with previous CABG. Patients with TIMI flow less than II. Patients with residual stenosis more than 70 % in major artery. Cardiogenic shock.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Esraa Sayed Hamed

Asyut, 23123, Egypt

Location

Related Publications (4)

• Tu C, Xie L, Wang Z, Zhang L, Wu H, Ni W, Li C, Li L, Zeng Y. Association between ceramides and coronary artery stenosis in patients with coronary artery disease. Lipids Health Dis. 2020 Jun 25;19(1):151. doi: 10.1186/s12944-020-01329-0.

  PMID: 32586390 BACKGROUND

• Pan W, Li L, Sun M, Wang C, Fang S, Yu B. Plasma ceramides are associated with coronary atherosclerotic burden in patients with ST-segment elevation myocardial infarction. Int J Cardiol. 2020 Dec 1;320:155-160. doi: 10.1016/j.ijcard.2020.08.010. Epub 2020 Aug 12.

  PMID: 32800902 BACKGROUND

• Mantovani A, Bonapace S, Lunardi G, Canali G, Dugo C, Vinco G, Calabria S, Barbieri E, Laaksonen R, Bonnet F, Byrne CD, Targher G. Associations between specific plasma ceramides and severity of coronary-artery stenosis assessed by coronary angiography. Diabetes Metab. 2020 Apr;46(2):150-157. doi: 10.1016/j.diabet.2019.07.006. Epub 2019 Aug 3.

  PMID: 31386900 BACKGROUND

• Tu CC, Wan BY, Zhao XL, Li CX, Wu HM, Zhang LL, Li L, Zeng Y. [Value of ceramide in the diagnosis and risk prediction of coronary artery disease]. Zhonghua Yi Xue Za Zhi. 2019 Oct 22;99(39):3089-3092. doi: 10.3760/cma.j.issn.0376-2491.2019.39.010. Chinese.

  PMID: 31648453 BACKGROUND

Study Officials

• mohamed abdel - ghani, professor

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

esraa RESIDENT sayed

CONTACT

01060558484; esraa.sayed3369@gmail.com

salwa Rushdy, professor

CONTACT

01223971267; Salwademitry@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: principle investigator

Study Record Dates

• First Submitted: September 27, 2020
• First Posted: October 1, 2020
• Study Start: September 1, 2020
• Primary Completion: September 1, 2020
• Study Completion: October 1, 2021
• Last Updated: October 1, 2020

Record last verified: 2020-09

Locations

EG (1)