Spot Urine Oxalate to Creatinine Ratio and 24 Hours Urinary Oxalate

NCT04571359 | Completed

• 1 other identifier: 5084-Pat-ERC-17
• Study Type: observational
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

The evaluation of 24 hour urinary oxalate excretion is the gold standard for diagnosing Hyperoxaluria in patients with recurrent urolithiasis. The relationship of oxalate measurement between spot and 24 hour urine sample has not been studied in Pakistani population before. Thus, it is necessary to see if spot urine samples show good correlation with 24 hour urine samples in our population where the frequency of hyperoxaluria in patients with urolithiasis is reported to be 64.5%. Also, the various pre analytical issues associated with 24 hour urinary collection which may lead to the incorrect or misdiagnosis, need for duplicate testing consuming extra resources and man power. We therefore, in this study, want to see the correlation between 24 hour urinary oxalate and oxalate to creatinine ratio. The aim of our study is to determine the relationship between 24 hour urinary oxalate and spot urine oxalate to creatinine ratio and to identify if oxalate to creatinine ratio can be used as an alternative to 24 hour urinary oxalate

Conditions

Urolithiasis; Hyperoxaluria

Keywords

24-hour urinary oxalate; Spot oxalate to creatinine ratio

Outcome Measures

Primary Outcomes (1)

• Relationship between 24 hour urinary oxalate excretion and spot urine oxalate to creatinine ratio

  Relationship between 24 hour urinary oxalate excretion and spot urine oxalate to creatinine ratio to determine its clinical utility against the use of 24 hour urinary oxalate estimation which is the standard practice.

  1 year

Interventions

Oxalate to creatinine ratio OTHER

Comparsion between 24 hours urine oxalate and spot urine oxalate to creatinine ratio

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients with history of kidney stones presenting at the Clinical Laboratory for 24 hours urine oxalate estimation.

You may qualify if:

• Patients with history of kidney stones.
• All patients investigated for 24 hour urinary oxalate excretion.
• Patients between 18 years to 60 years would be included.
• Both genders will be included.

You may not qualify if:

• Debilitated patients or bed ridden patients in whom proper and complete 24 hour urine collection will be troublesome.
• Patients with renal failure/end stage renal disease, in whom urinary oxalate is no longer an indicator of disease status.

Sponsors & Collaborators

• Aga Khan University: lead

Study Sites (1)

Syed bilal hashmi

Karachi, Pakistan, Sindh, 75800, Pakistan

Location

Related Publications (2)

• Hagler L, Herman RH. Oxalate metabolism. I. Am J Clin Nutr. 1973 Jul;26(7):758-65. doi: 10.1093/ajcn/26.6.758. No abstract available.

  PMID: 4576881 BACKGROUND

• Hoppe B. An update on primary hyperoxaluria. Nat Rev Nephrol. 2012 Jun 12;8(8):467-75. doi: 10.1038/nrneph.2012.113.

  PMID: 22688746 BACKGROUND

MeSH Terms

Conditions

Urolithiasis; Hyperoxaluria

Condition Hierarchy (Ancestors)

Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Kidney Diseases

Study Officials

• Syed bilal hashmi

  AKUH

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: September 27, 2020
• First Posted: October 1, 2020
• Study Start: February 1, 2019
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: October 1, 2020

Record last verified: 2020-09

Locations

PA (1)