Elastography in Superficial Lymphadenopathy
Value of Ultrasound Elastography in Characterization of Superficial Lymphadenopathy
1 other identifier
observational
70
0 countries
N/A
Brief Summary
Evaluation of the role of Ultrasound Elastography in differentiation between benign and malignant lymph nodes and its additional information over the classic gray scale and color Doppler ultrasound.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Feb 2021
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
September 14, 2020
CompletedFirst Posted
Study publicly available on registry
September 24, 2020
CompletedStudy Start
First participant enrolled
February 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
October 1, 2022
CompletedJanuary 26, 2021
January 1, 2021
8 months
September 14, 2020
January 23, 2021
Conditions
Outcome Measures
Primary Outcomes (2)
To evaluate the role of Ultrasound Elastography in differentiation between benign and malignant lymph nodes by its additional information over the classic gray scale and color Doppler ultrasound.
Strain elastography (SE): measures tissue displacements along the axis of an applied force. Strain elastography provides semi - quantitative scores based on elastographic pattern (scores based on percentage of stiff area within the lesion) and strain ratio (ratio between the lesion and the background tissue).
one year
To evaluate the role of Ultrasound Elastography in differentiation between benign and malignant lymph nodes by its additional information over the classic gray scale and color Doppler ultrasound.
Shear wave elastography (SWE): measures a different type of waves that is also produced when tissues are mechanically stimulated. Shear wave elastography is also a quantitative method of analysis for elasticity images using shear wave speed (m/s).
one year
Study Arms (1)
Patients with Superficial Lymphadenopathy
Interventions
Eligibility Criteria
patients with enlarged lymph nodes.
You may qualify if:
- Patients presented with enlarged lymph nodes by clinical examination.
You may not qualify if:
- Patients who previously receive any medical treatment or chemo or radiotherapy.
- Patients who previously underwent fine needle aspiration cytology or biopsy.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (8)
Kilic A, Colakoglu Er H. Virtual touch tissue imaging quantification shear wave elastography for determining benign versus malignant cervical lymph nodes: a comparison with conventional ultrasound. Diagn Interv Radiol. 2019 Mar;25(2):114-121. doi: 10.5152/dir.2019.18406.
PMID: 30774094BACKGROUNDAcu L, Oktar SO, Acu R, Yucel C, Cebeci S. Value of Ultrasound Elastography in the Differential Diagnosis of Cervical Lymph Nodes: A Comparative Study With B-mode and Color Doppler Sonography. J Ultrasound Med. 2016 Nov;35(11):2491-2499. doi: 10.7863/ultra.15.09019.
PMID: 27794132BACKGROUNDNaik RM, Pai A, Guruprasad Y, Singh R. Efficacy of colour Doppler ultrasound in diagnosis of cervical lymphadenopathy. J Maxillofac Oral Surg. 2013 Jun;12(2):123-9. doi: 10.1007/s12663-012-0395-1. Epub 2012 Aug 24.
PMID: 24431828BACKGROUNDSuh CH, Choi YJ, Baek JH, Lee JH. The diagnostic performance of shear wave elastography for malignant cervical lymph nodes: A systematic review and meta-analysis. Eur Radiol. 2017 Jan;27(1):222-230. doi: 10.1007/s00330-016-4378-3. Epub 2016 May 5.
PMID: 27147221BACKGROUNDDesmots F, Fakhry N, Mancini J, Reyre A, Vidal V, Jacquier A, Santini L, Moulin G, Varoquaux A. Shear Wave Elastography in Head and Neck Lymph Node Assessment: Image Quality and Diagnostic Impact Compared with B-Mode and Doppler Ultrasonography. Ultrasound Med Biol. 2016 Feb;42(2):387-98. doi: 10.1016/j.ultrasmedbio.2015.10.019. Epub 2015 Nov 23.
PMID: 26617244BACKGROUNDBhatia KS, Lee YY, Yuen EH, Ahuja AT. Ultrasound elastography in the head and neck. Part I. Basic principles and practical aspects. Cancer Imaging. 2013 Jul 22;13(2):253-9. doi: 10.1102/1470-7330.2013.0026.
PMID: 23876352BACKGROUNDCheng KL, Choi YJ, Shim WH, Lee JH, Baek JH. Virtual Touch Tissue Imaging Quantification Shear Wave Elastography: Prospective Assessment of Cervical Lymph Nodes. Ultrasound Med Biol. 2016 Feb;42(2):378-86. doi: 10.1016/j.ultrasmedbio.2015.10.003. Epub 2015 Nov 6.
PMID: 26553206BACKGROUNDChoi YJ, Lee JH, Lim HK, Kim SY, Han MW, Cho KJ, Baek JH. Quantitative shear wave elastography in the evaluation of metastatic cervical lymph nodes. Ultrasound Med Biol. 2013 Jun;39(6):935-40. doi: 10.1016/j.ultrasmedbio.2012.12.009. Epub 2013 Feb 27.
PMID: 23453381BACKGROUND
Related Links
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
September 14, 2020
First Posted
September 24, 2020
Study Start
February 1, 2021
Primary Completion
October 1, 2021
Study Completion
October 1, 2022
Last Updated
January 26, 2021
Record last verified: 2021-01