Selective Versus Nonselective Alpha-blockade Prior to Pheochromocytoma Resection - Systematic Review and Meta-analysis
1 other identifier
observational
1,344
1 country
1
Brief Summary
Our aim was to systematically evaluate the current data on the efficacy of pretreatment with either selective or nonselective alpha-blockade on the hemodynamic instability and morbidity during pheochromocytoma resection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Aug 2020
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2020
CompletedFirst Submitted
Initial submission to the registry
September 17, 2020
CompletedFirst Posted
Study publicly available on registry
September 21, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
November 2, 2020
CompletedJune 18, 2021
June 1, 2021
1 month
September 17, 2020
June 15, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Intraoperative maximum systolic blood pressure (mm Hg)
intraoperative
Secondary Outcomes (13)
Frequency of systolic blood pressure >160 mmHg
intraoperative
Intraoperative maximum diastolic blood pressure (mm Hg)
intraoperative
intraoperative maximum heart rate (beats/min)
intraoperative
Intraoperative minimum systolic blood pressure (mm Hg)
intraoperative
Intraoperative vasopressors administration
intraoperative
- +8 more secondary outcomes
Study Arms (2)
The selective alpha-blockade group
Patients treated with selective alpha-blockade before pheochromocytoma surgery
The non-selective alpha-blockade group
Patients treated with non-selective alpha-blockade before pheochromocytoma surgery
Interventions
Patients treated with selective alpha-blockade (prazosin, terazosin, doxazosin)
Patients treated with non-selective alpha-blockade (phenoxybenzamine)
Eligibility Criteria
RCTs and non-randomized controlled studies comparing preoperative selective α-blockade (SAB) with nonselective α-blockade (NAB) in pheochromocytoma surgery in adults were eligible for inclusion.
You may qualify if:
- All patients who received selective or nonselective alpha-blockade prior to pheochromocytoma resection
You may not qualify if:
- Patients who did not receive alpha blockade
- Patients not undergoing surgery
- No comparison for selective and non-selective pretreatment in the study
- Studies without primary or sufficient data (reviews, guidelines, meeting abstracts, letters),
- Studies reported in a language other than English
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
2nd Department of General Surgery, Jagiellonian University Medical College
Krakow, Polska, 37-111, Poland
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- OTHER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
September 17, 2020
First Posted
September 21, 2020
Study Start
August 1, 2020
Primary Completion
September 1, 2020
Study Completion
November 2, 2020
Last Updated
June 18, 2021
Record last verified: 2021-06