Analysis of the Influence of Desensitizing Treatments on the Pulp Inflammatory Response in Bleached Teeth

NCT04548674 | Completed

• 1 other identifier: UFPara-008
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized, controlled, blinded clinical trial evaluated the effectiveness of different desensitizing protocols in preventing pulp inflammation after bleaching treatment with 35% hydrogen peroxide (PH) (Whiteness PH 35%).

Conditions

Pulp Inflammation

Keywords

Therapies; Caspase 3; Immunohistochemistry

Outcome Measures

Primary Outcomes (1)

• Pulp inflammation

  Evaluation of pulp inflammation through immunohistochemistry of the third molar whitening or not

  3 days After extraction of third molars

Study Arms (5)

Positive Control Group

PLACEBO COMPARATOR

Whiteness HP 35%

Other: Whiteness HP 35%

Laser Group

EXPERIMENTAL

Whiteness HP 35% + Laser

Other: Whiteness HP 35%; Device: Whiteness HP 35% + LASER

CPP Group

EXPERIMENTAL

Whiteness HP 35% + CPP

Other: Whiteness HP 35%; Other: Whiteness HP 35% + CPP

Nano Group

EXPERIMENTAL

Whiteness HP 35% + NANO

Other: Whiteness HP 35%; Other: Whiteness HP 35% + NANO

Negative Control

NO INTERVENTION

Without intervention

Interventions

Whiteness HP 35% OTHER

Single application of 45 minutes on the buccal surfaces of third molars, with an average thickness of 1 mm

CPP Group; Laser Group; Nano Group; Positive Control Group

Whiteness HP 35% + LASER DEVICE

A dose of LASER (60 J / cm2, for 16 seconds) was applied at two points, one point in the cervical region and another in the center of the buccal surface of the third molars, using visible infrared LASER therapy (Photon III / DMC, São Carlos, SP, Brazil), with a wavelength of 808 nm, and AsGaAl, as an active medium.

Laser Group

Whiteness HP 35% + CPP OTHER

Topical application of casein phosphopeptide amorphous calcium phosphate fluoride CPP-ACPF (My Paste Plus, Recaldent, GC, USA) with the aid of a microbrush (KG Sorensen, SP, Brazil) in a passive way for 5 minutes.

CPP Group

Whiteness HP 35% + NANO OTHER

A topical application of nanohydroxyapatite (Nano P FGM, SC, Brazil) was performed with the aid of a microbrush (KG Sorensen, SP, Brazil) in a passive way for 5 minutes after teeth whitening.

Nano Group

Eligibility Criteria

• Age: 20 Years - 26 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Lower third molars class I position A
• Maxillary third molars horizontal position A
• Absence of caries and enamel fracture
• Absence of periodontal disease
• Extraction of third molars for orthodontic reasons
• No allergy to the anesthetic and positive pulp sensitivity test

You may not qualify if:

• Calcification in the middle third of the root
• Drug users or smokers
• Patients who have already done whitening
• Root apex with incomplete formation and patients with systemic problems that would make surgery impossible

Sponsors & Collaborators

• Universidade Federal do Para: lead

Study Sites (1)

Universidade Federal do Pará

Belém, Pará, 66075-110, Brazil

Location

MeSH Terms

Conditions

Spinocerebellar Ataxias

Interventions

Lasers; 6-chloro-2-(1-piperazinyl)pyrazine

Condition Hierarchy (Ancestors)

Cerebellar Ataxia; Cerebellar Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Spinocerebellar Degenerations; Spinal Cord Diseases; Heredodegenerative Disorders, Nervous System; Neurodegenerative Diseases; Ataxia; Dyskinesias; Neurologic Manifestations; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Optical Devices; Equipment and Supplies; Radiation Equipment and Supplies

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor Clínico

Study Record Dates

• First Submitted: September 1, 2020
• First Posted: September 14, 2020
• Study Start: August 20, 2018
• Primary Completion: March 15, 2019
• Study Completion: June 30, 2019
• Last Updated: September 14, 2020

Record last verified: 2020-09

Locations

BR (1)