Biomarkers of Meats and Potatoes Intake

NCT04548362 | Completed

• 1 other identifier: H-150204011H
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-over meal study is a four-way intervention with 12 volunteers randomized at the same time to four meals with fried meats (beef, pork, chicken and amino-acid matched non-meat control) and to four meals with potato products (boiled, chips, fries, and a control with boiled white rice) to search for biomarkers of intake.

Conditions

Nutrition Disorders

Keywords

Biomarkers of food intake

Outcome Measures

Primary Outcomes (2)

• meat intake biomarkers

  To identify intake biomarkers of general meat, red meat and poultry

  0-48 hours

• Potato intake biomarkers

  To identify intake biomarkers of general potato, fried potato and white rice

  0-48 hours

Study Arms (2)

Meat meals

EXPERIMENTAL

This arm contains a 4-way cross-over intervention study with meats

Other: Meat arm

Starchy meals

EXPERIMENTAL

This arm contains a 4-way cross-over intervention study with

Other: Starchy foods arm

Interventions

Meat arm OTHER

Randomised sequence of pork, beef, chicken meat, and an egg white/pea combination

Meat meals

Starchy foods arm OTHER

Randomised sequence of boiled potato, fried potato, potato crisps, and boiled white rice

Starchy meals

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• healthy

You may not qualify if:

• non-pregnant, no abuse of alcohol or drugs, no chronic medication except p-pills

Sponsors & Collaborators

• Professor Lars Ove Dragsted: lead

Study Sites (1)

Lars Dragsted

Frederiksberg, 1958, Denmark

Location

Related Publications (2)

• Zhou X, Ulaszewska MM, Cuparencu C, De Gobba C, Vazquez-Manjarrez N, Gurdeniz G, Chen J, Mattivi F, Dragsted LO. Urine Metabolome Profiling Reveals Imprints of Food Heating Processes after Dietary Intervention with Differently Cooked Potatoes. J Agric Food Chem. 2020 Jun 3;68(22):6122-6131. doi: 10.1021/acs.jafc.0c01136. Epub 2020 May 8.

  PMID: 32338001 BACKGROUND

• Cuparencu C, Rinnan A, Dragsted LO. Combined Markers to Assess Meat Intake-Human Metabolomic Studies of Discovery and Validation. Mol Nutr Food Res. 2019 Sep;63(17):e1900106. doi: 10.1002/mnfr.201900106. Epub 2019 Jun 13.

  PMID: 31141834 RESULT

MeSH Terms

Conditions

Nutrition Disorders

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases

Study Officials

• Catalina Cuparencu, PhD

  University of Copenhagen

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: It is not possible to mask foods and for the explorative analysis of results, masking is not required.
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Professor

Model Details: Subjects were randomised to four meals with meats and starchy foods in such a way that all volunteers had each meat and each starchy food once and so that all combinations of meats and starchy foods were equally common. Each volunteer was also randomised to the sequence of the meals.

Study Record Dates

• First Submitted: September 7, 2020
• First Posted: September 14, 2020
• Study Start: February 15, 2016
• Primary Completion: May 30, 2016
• Study Completion: May 30, 2016
• Last Updated: April 28, 2021

Record last verified: 2021-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, ICF
• Time Frame: 1 year
• Access Criteria: after contact with PI; only anonymized information will be provided.

Locations

DK (1)