NCT04533815

Brief Summary

This was a pilot study (R61) to prepare for a full clinical trial (R33) aiming to improve clinical outcomes for an important, growing, and vulnerable population-nursing home (NH) residents with Alzheimer's disease or related dementias (ADRDs). The goal was to pilot and refine the research methods and intervention that would be subsequently evaluated in a full implementation trial (hybrid type III). The goal of the evidence-based intervention (LOCK) that was refined in this pilot study and will be evaluated in the subsequent full clinical trial is to improve the sleep of NH residents with ADRD.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
23

participants targeted

Target at below P25 for not_applicable alzheimer-disease

Timeline
Completed

Started May 2021

Shorter than P25 for not_applicable alzheimer-disease

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

August 22, 2020

Completed
10 days until next milestone

First Posted

Study publicly available on registry

September 1, 2020

Completed
8 months until next milestone

Study Start

First participant enrolled

May 5, 2021

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2022

Completed
1.4 years until next milestone

Results Posted

Study results publicly available

January 10, 2024

Completed
Last Updated

January 10, 2024

Status Verified

December 1, 2023

Enrollment Period

1.3 years

First QC Date

August 22, 2020

Results QC Date

December 19, 2023

Last Update Submit

December 19, 2023

Conditions

Outcome Measures

Primary Outcomes (1)

  • Sleep (Actigraph Measurement)

    Total sleep time (total minutes asleep each nighttime period - 7pm to 7am)

    15 week sleep intervention period

Study Arms (1)

LOCK sleep intervention

EXPERIMENTAL

Nursing home staff receive the LOCK sleep intervention training and thus provide to nursing home residents with dementia the LOCK sleep intervention

Behavioral: LOCK sleep intervention

Interventions

Nursing home staff are trained to use a collaborative problem-solving approach to sleep quality improvement using front-line huddling

LOCK sleep intervention

Eligibility Criteria

Age50 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Nursing home residents aged \>=50 years with an Alzheimer disease or related dementia (ADRD) diagnosis, identified by nursing home staff participating in frontline LOCK sleep huddles as having sleep problems

You may not qualify if:

  • residents with a high risk of OSA who are not being treated for OSA because actigraph measurements are inaccurate in that population.
  • residents who have a persistent bilateral resting tremor or paralysis in both arms (a subset of persons with Parkinson's disease and related significant tremor-causing diagnoses), due to actigraph measurement inaccuracies

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

The University of Alabama

Tuscaloosa, Alabama, 35487-0348, United States

Location

Related Publications (1)

  • Snow AL, Loup J, Morgan RO, Richards K, Parmelee PA, Baier RR, McCreedy E, Frank B, Brady C, Fry L, McCullough M, Hartmann CW. Enhancing sleep quality for nursing home residents with dementia: a pragmatic randomized controlled trial of an evidence-based frontline huddling program. BMC Geriatr. 2021 Apr 27;21(1):281. doi: 10.1186/s12877-021-02189-8.

    PMID: 33906631BACKGROUND

MeSH Terms

Conditions

Alzheimer DiseaseDementiaSleep Wake DisordersParasomnias

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental DisordersNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Dr. Lynn Snow
Organization
University of Alabama

Study Officials

  • Lynn Snow, PhD

    The University of Alabama

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
TREATMENT
Intervention Model
SINGLE GROUP
Model Details: Pilot study in 3 nursing homes. The pilot phase (R61) informs the next phase (R33), a clinical trial using an incomplete, stepped, wedge cluster randomized controlled trial (RCT) design with 24 nursing homes. Each nursing home in the full clinical trial (R33) will act as its own control (4 staggered steps, with 6 nursing homes per step).
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

August 22, 2020

First Posted

September 1, 2020

Study Start

May 5, 2021

Primary Completion

August 31, 2022

Study Completion

August 31, 2022

Last Updated

January 10, 2024

Results First Posted

January 10, 2024

Record last verified: 2023-12

Data Sharing

IPD Sharing
Will share

The research team will share de-identified participant data by depositing data files and associated code books and analysis files with the data repository dataverse (dataverse.org). The research team will follow the University of Alabama IRB guidance and approval for ensuring that the data is appropriately de-identified before posting to dataverse. The IRB-approved informed consent and HIPPAA forms seek participant permission for broad inclusion of participant data for these data sharing and secondary analysis purposes.

Shared Documents
STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
Time Frame
Within 6 months of study closure, for 5 years
Access Criteria
Under development. Contact PI.

Locations