Mother-infant Bonding During COVID-19

NCT04531618 | Active Not Recruiting

• 1 other identifier: AAAT0140
• Study Type: interventional
• Target: 132
• Locations: 1 country
• Sites: 1

Brief Summary

This study will assess whether the promotion of emotional exchange between mother and infant during the first four months of life improves primarily mother-child early relational health (ERH) and secondarily child neurodevelopmental and maternal mental health outcomes. In prior research on preterm infants, a similar intervention demonstrated increased quality of maternal caregiving behaviors and significant improvements in premature infants' neurodevelopment across multiple domains, including social-relatedness and attention problems. The goal of the emotional exchange intervention is to help mothers provide appropriate stimulation crucial for social, emotional, and neurobehavioral development, by helping the mother and child become attuned, or 'in sync', with each other. Measures of ERH, such as bonding, maternal sensitivity, and mother-child emotional connection will be compared between two groups: one receiving newborn parenting education and the other undergoing facilitated emotional exchange. Assessments will involve videos of mother-infant interactions during each intervention session and follow-up surveys conducted as part of a linked Institutional Review Board-approved study. Data collected in this study will contribute to understanding the underlying mechanisms of mother-infant interactions and their role in shaping optimal neurodevelopmental trajectories for infants and maternal mental health.

Conditions

Child Development; Mother-Infant Interaction; Relation, Parent-Child

Keywords

Emotional Connection; Emotional Exchange; Early Relational Health; Newborn Care

Outcome Measures

Primary Outcomes (3)

• Change in Emotional Synchrony (ES) Scale

  The Emotional Synchrony (ES) scale is an observational quantitative tool used to assess interactions between infants and mothers, validated by the research team. Emotional synchrony is defined as a dyadic property that emerges when mother and child function as a unit, rather than as separate individuals. Coders use a 0-100 slider scale where higher scores indicate stronger emotional connections. The 'magnetism' between a mother and child is quantified based on physical and emotional elements observed during their interaction, including mutual eye gaze or aversion, and serve-and-return conversations. ES scores are recorded at baseline and then at 4 and 6-month follow-ups by researchers observing the interactions for 2-5 minutes. Changes in scores from baseline to 6 months are analyzed for each group.

  Baseline, 4 months, 6 months

• Change in Maternal Caregiving Behavior Score

  The quality of caregiving in the domains of Acceptance versus Rejection, Sensitivity versus Insensitivity, Consideration versus Intrusiveness, Quality of Physical Contact, Quality of Vocal contact, and Effectiveness of Response to Baby's Crying, will be each measured on a scale from 1-9, with 9 indicating higher quality caregiving. These scores will be averaged to produce a composite score (between 1-9) that is the average of all sub-scales. During each Zoom call, following the mother-infant interaction video but prior to intervention for the emotional exchange group, a recording will be obtained where mother undresses infant, changes diaper, and redresses infant. This video will be scored with an adaption of the Ainsworth System for Rating Maternal Care-Giving Behavior.

  Baseline, 4 months

• Postpartum Bonding Questionnaire (PBQ)

  A self-report tool that measures mother-infant bonding in the postpartum period. The PBQ targets maternal feelings, experiences, and attitudes toward her infant. Items are scored on a 6-point Likert scale (0-Always to 5-Never). The PBQ consists of four subscales; general bonding disorders (12 items; 1, 2, 6, 7, 8, 9, 10, 12, 13, 15, 16, 17), severe mother-infant relationship disorders (7 items; 3, 4, 5, 11, 14, 21, 23), infant-focused anxiety (4 items; 19, 20, 22, 25), and risk of abuse (2 items; 18, 24). The total cumulative score, ranging from 0 to 125, is used to screen for general bonding disorders (cut-off score ≥26), and severe bonding disturbances (cut-off score ≥40). A lower score indicates better bonding.

  Baseline, 4 months

Secondary Outcomes (5)

• Change in Ages and Stages questionnaire (ASQ-3) Score

  6 months

• Change in Social-Emotional Questionnaire (ASQ-SE) Score

  6 months

• Maternal Anxiety using the State/Trait Anxiety Index (STAI)

  4 months

• Patient Health Questionnaire (PHQ9)

  4 months

• Perceived Stress Scale (PSS)

  4 months

Study Arms (2)

Emotional Exchange (EE)

EXPERIMENTAL

Receives a facilitated emotional exchange session over Zoom in the Well Baby Nursery and up to 7 subsequent Zoom sessions over the next 4 months.

Behavioral: Emotional Exchange (EE)

Newborn Care (NC)

ACTIVE COMPARATOR

Receives didactic newborn parenting education delivering developmentally appropriate content over zoom at the same time points as the emotional exchange group.

Other: Newborn Care (NC)

Interventions

Emotional Exchange (EE) BEHAVIORAL

These sessions, conducted by a trained study staff member through Zoom, will involve storytelling and discussing emotional experiences with the baby, with prompts like sharing about the pregnancy or reactions to the baby's smiles.

Emotional Exchange (EE)

Newborn Care (NC) OTHER

Newborn Care (NC) is a teaching curriculum designed to provide mothers with developmentally appropriate information about newborn care. The curriculum is adapted from previously studied literature that increased maternal knowledge about both medical and developmental concerns.

Newborn Care (NC)

Eligibility Criteria

• Age: 12 Hours - 72 Hours
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Mother agrees to participate in a linked study involving additional surveys and assessments
• Newborn born between 35 weeks and 40 weeks and 6 days gestational age
• Newborn is a singleton
• Mother can speak English or Spanish

You may not qualify if:

• Newborn born at less than 35 weeks and 0 days gestational age
• Newborn born at more than 40 weeks and 6 days gestational age
• Infant's attending physician does not recommend enrollment in the study based on newborn health concerns or diagnoses, or based on concern regarding maternal history of maternal substance abuse, severe psychiatric illness or psychosis
• Mother and/or infant has a medical condition that precludes intervention components
• Newborn is a twin or other multiple at birth
• Mother is unwilling to be video recorded

Sponsors & Collaborators

• Columbia University: lead

Study Sites (1)

Morgan Stanley Children's Hospital

New York, New York, 10032, United States

Location

Related Publications (54)

• Abidin RR. Parenting stress and the utilization of pediatric services. Child Health Care. 1983 Fall;11(2):70-3. doi: 10.1207/s15326888chc1102_5.

  PMID: 10262147 BACKGROUND

• Achenbach TM, Rescorla L. Manual for the ASEBA Preschool Forms &Amp; Profiles: an Integrated System of Multi-Informant Assessment. Burlington, VT: ASEBA; 2000.

  BACKGROUND

• Als, H. Reading the premature infant. In: Nurturing the Premature Infant: Developmental Interventions in the Neonatal Intensive Care Nursery. New York: Oxford University Press; 1999.

  BACKGROUND

• Bailey RC, Kamenga MC, Nsuami MJ, Nieburg P, St Louis ME. Growth of children according to maternal and child HIV, immunological and disease characteristics: a prospective cohort study in Kinshasa, Democratic Republic of Congo. Int J Epidemiol. 1999 Jun;28(3):532-40. doi: 10.1093/ije/28.3.532.

  PMID: 10405861 BACKGROUND

• Benasich AA, Thomas JJ. Developmental Disorders of Language. Encyclopedia of Cognitive Science Nadel/Cognitive. 2006.

  BACKGROUND

• Boivin MJ, Maliwichi-Senganimalunje L, Ogwang LW, Kawalazira R, Sikorskii A, Familiar-Lopez I, Kuteesa A, Nyakato M, Mutebe A, Namukooli JL, Mallewa M, Ruisenor-Escudero H, Aizire J, Taha TE, Fowler MG. Neurodevelopmental effects of ante-partum and post-partum antiretroviral exposure in HIV-exposed and uninfected children versus HIV-unexposed and uninfected children in Uganda and Malawi: a prospective cohort study. Lancet HIV. 2019 Aug;6(8):e518-e530. doi: 10.1016/S2352-3018(19)30083-9. Epub 2019 May 20.

  PMID: 31122797 BACKGROUND

• Brunelli SA, Curley JP, Gudsnuk K, Champagne FA, Myers MM, Hofer MA, Welch MG. Variations in maternal behavior in rats selected for infant ultrasonic vocalization in isolation. Horm Behav. 2015 Sep;75:78-83. doi: 10.1016/j.yhbeh.2015.08.007. Epub 2015 Aug 22.

  PMID: 26306860 BACKGROUND

• Cassidy AR, Williams PL, Leidner J, Mayondi G, Ajibola G, Makhema J, Holding PA, Powis KM, Batlang O, Petlo C, Shapiro R, Kammerer B, Lockman S. In Utero Efavirenz Exposure and Neurodevelopmental Outcomes in HIV-exposed Uninfected Children in Botswana. Pediatr Infect Dis J. 2019 Aug;38(8):828-834. doi: 10.1097/INF.0000000000002332.

  PMID: 30985518 BACKGROUND

• Cesari M, Penninx BW, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, Rubin SM, Ding J, Simonsick EM, Harris TB, Pahor M. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation. 2003 Nov 11;108(19):2317-22. doi: 10.1161/01.CIR.0000097109.90783.FC. Epub 2003 Oct 20.

  PMID: 14568895 BACKGROUND

• Chapieski ML, Evankovich KD. Behavioral effects of prematurity. Semin Perinatol. 1997 Jun;21(3):221-39. doi: 10.1016/s0146-0005(97)80065-1.

  PMID: 9205977 BACKGROUND

• D'Anna-Hernandez KL, Ross RG, Natvig CL, Laudenslager ML. Hair cortisol levels as a retrospective marker of hypothalamic-pituitary axis activity throughout pregnancy: comparison to salivary cortisol. Physiol Behav. 2011 Aug 3;104(2):348-53. doi: 10.1016/j.physbeh.2011.02.041. Epub 2011 Mar 21.

  PMID: 21397617 BACKGROUND

• Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010 Mar 1;67(5):446-57. doi: 10.1016/j.biopsych.2009.09.033. Epub 2009 Dec 16.

  PMID: 20015486 BACKGROUND

• Dumitriu D, Emeruwa UN, Hanft E, Liao GV, Ludwig E, Walzer L, Arditi B, Saslaw M, Andrikopoulou M, Scripps T, Baptiste C, Khan A, Breslin N, Rubenstein D, Simpson LL, Kyle MH, Friedman AM, Hirsch DS, Miller RS, Fernandez CR, Fuchs KM, Keown MK, Glassman ME, Stephens A, Gupta A, Sultan S, Sibblies C, Whittier S, Abreu W, Akita F, Penn A, D'Alton ME, Orange JS, Goffman D, Saiman L, Stockwell MS, Gyamfi-Bannerman C. Outcomes of Neonates Born to Mothers With Severe Acute Respiratory Syndrome Coronavirus 2 Infection at a Large Medical Center in New York City. JAMA Pediatr. 2021 Feb 1;175(2):157-167. doi: 10.1001/jamapediatrics.2020.4298.

  PMID: 33044493 BACKGROUND

• Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med. 1999 Feb 11;340(6):448-54. doi: 10.1056/NEJM199902113400607. No abstract available.

  PMID: 9971870 BACKGROUND

• Evans C, Jones CE, Prendergast AJ. HIV-exposed, uninfected infants: new global challenges in the era of paediatric HIV elimination. Lancet Infect Dis. 2016 Jun;16(6):e92-e107. doi: 10.1016/S1473-3099(16)00055-4. Epub 2016 Mar 31.

  PMID: 27049574 BACKGROUND

• Flacking R, Lehtonen L, Thomson G, Axelin A, Ahlqvist S, Moran VH, Ewald U, Dykes F; Separation and Closeness Experiences in the Neonatal Environment (SCENE) group. Closeness and separation in neonatal intensive care. Acta Paediatr. 2012 Oct;101(10):1032-7. doi: 10.1111/j.1651-2227.2012.02787.x. Epub 2012 Aug 2.

  PMID: 22812674 BACKGROUND

• Fleming AS, O'Day DH, Kraemer GW. Neurobiology of mother-infant interactions: experience and central nervous system plasticity across development and generations. Neurosci Biobehav Rev. 1999 May;23(5):673-85. doi: 10.1016/s0149-7634(99)00011-1.

  PMID: 10392659 BACKGROUND

• Gozali A, Gibson S, Lipton LR, Pressman AW, Hammond BS, Dumitriu D. Assessing the effectiveness of a pediatrician-led newborn parenting class on maternal newborn-care knowledge, confidence and anxiety: A quasi-randomized controlled trial. Early Hum Dev. 2020 Aug;147:105082. doi: 10.1016/j.earlhumdev.2020.105082. Epub 2020 May 23.

  PMID: 32512498 BACKGROUND

• Hane AA, LaCoursiere JN, Mitsuyama M, Wieman S, Ludwig RJ, Kwon KY, V Browne J, Austin J, M Myers M, Welch MG. The Welch Emotional Connection Screen: validation of a brief mother-infant relational health screen. Acta Paediatr. 2019 Apr;108(4):615-625. doi: 10.1111/apa.14483. Epub 2018 Aug 13.

  PMID: 29959878 BACKGROUND

• Hane AA, Myers MM, Hofer MA, Ludwig RJ, Halperin MS, Austin J, Glickstein SB, Welch MG. Family nurture intervention improves the quality of maternal caregiving in the neonatal intensive care unit: evidence from a randomized controlled trial. J Dev Behav Pediatr. 2015 Apr;36(3):188-96. doi: 10.1097/DBP.0000000000000148.

  PMID: 25757070 BACKGROUND

• Helle N, Barkmann C, Bartz-Seel J, Diehl T, Ehrhardt S, Hendel A, Nestoriuc Y, Schulte-Markwort M, von der Wense A, Bindt C. Very low birth-weight as a risk factor for postpartum depression four to six weeks postbirth in mothers and fathers: Cross-sectional results from a controlled multicentre cohort study. J Affect Disord. 2015 Jul 15;180:154-61. doi: 10.1016/j.jad.2015.04.001. Epub 2015 Apr 10.

  PMID: 25911131 BACKGROUND

• Holditch-Davis D, Bartlett TR, Blickman AL, Miles MS. Posttraumatic stress symptoms in mothers of premature infants. J Obstet Gynecol Neonatal Nurs. 2003 Mar-Apr;32(2):161-71. doi: 10.1177/0884217503252035.

  PMID: 12685667 BACKGROUND

• Klein BY, Tamir H, Hirschberg DL, Ludwig RJ, Glickstein SB, Myers MM, Welch MG. Oxytocin opposes effects of bacterial endotoxin on ER-stress signaling in Caco2BB gut cells. Biochim Biophys Acta. 2016 Feb;1860(2):402-11. doi: 10.1016/j.bbagen.2015.10.025. Epub 2015 Oct 28.

  PMID: 26520666 BACKGROUND

• Kyle MH, Glassman ME, Khan A, Fernandez CR, Hanft E, Emeruwa UN, Scripps T, Walzer L, Liao GV, Saslaw M, Rubenstein D, Hirsch DS, Keown MK, Stephens A, Mollicone I, Bence ML, Gupta A, Sultan S, Sibblies C, Whittier S, Abreu W, Akita F, Penn A, Orange JS, Saiman L, Welch MG, Gyamfi-Bannerman C, Stockwell MS, Dumitriu D. A review of newborn outcomes during the COVID-19 pandemic. Semin Perinatol. 2020 Nov;44(7):151286. doi: 10.1016/j.semperi.2020.151286. Epub 2020 Jul 23.

  PMID: 32826081 BACKGROUND

• Linden MA, Cepeda IL, Synnes A, Grunau RE. Stress in parents of children born very preterm is predicted by child externalising behaviour and parent coping at age 7 years. Arch Dis Child. 2015 Jun;100(6):554-8. doi: 10.1136/archdischild-2014-307390. Epub 2015 Mar 11.

  PMID: 25762532 BACKGROUND

• Myers MM, Grieve PG, Stark RI, Isler JR, Hofer MA, Yang J, Ludwig RJ, Welch MG. Family Nurture Intervention in preterm infants alters frontal cortical functional connectivity assessed by EEG coherence. Acta Paediatr. 2015 Jul;104(7):670-7. doi: 10.1111/apa.13007. Epub 2015 Apr 13.

  PMID: 25772627 BACKGROUND

• Neu J, Rushing J. Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis. Clin Perinatol. 2011 Jun;38(2):321-31. doi: 10.1016/j.clp.2011.03.008.

  PMID: 21645799 BACKGROUND

• Omoni AO, Ntozini R, Evans C, Prendergast AJ, Moulton LH, Christian PS, Humphrey JH. Child Growth According to Maternal and Child HIV Status in Zimbabwe. Pediatr Infect Dis J. 2017 Sep;36(9):869-876. doi: 10.1097/INF.0000000000001574.

  PMID: 28198792 BACKGROUND

• Powis KM, Slogrove AL, Okorafor I, Millen L, Posada R, Childs J, Abrams EJ, Sperling RS, Jao J. Maternal Perinatal HIV Infection Is Associated With Increased Infectious Morbidity in HIV-exposed Uninfected Infants. Pediatr Infect Dis J. 2019 May;38(5):500-502. doi: 10.1097/INF.0000000000002253.

  PMID: 30461574 BACKGROUND

• Radloff LS. The CES-D Scale: A Self-Report Depression Scale for Research in the General Population. Applied Psychological Measurement. 1977;1(3):385-401.

  BACKGROUND

• Raul JS, Cirimele V, Ludes B, Kintz P. Detection of physiological concentrations of cortisol and cortisone in human hair. Clin Biochem. 2004 Dec;37(12):1105-11. doi: 10.1016/j.clinbiochem.2004.02.010.

  PMID: 15589817 BACKGROUND

• Ridker PM, Hennekens CH, Buring JE, Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med. 2000 Mar 23;342(12):836-43. doi: 10.1056/NEJM200003233421202.

  PMID: 10733371 BACKGROUND

• Robbins CL, Hutchings Y, Dietz PM, Kuklina EV, Callaghan WM. History of preterm birth and subsequent cardiovascular disease: a systematic review. Am J Obstet Gynecol. 2014 Apr;210(4):285-297. doi: 10.1016/j.ajog.2013.09.020. Epub 2013 Sep 18.

  PMID: 24055578 BACKGROUND

• Robins DL, Fein D, Barton ML, Green JA. The Modified Checklist for Autism in Toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders. J Autism Dev Disord. 2001 Apr;31(2):131-44. doi: 10.1023/a:1010738829569.

  PMID: 11450812 BACKGROUND

• le Roux SM, Donald KA, Kroon M, Phillips TK, Lesosky M, Esterhuyse L, Zerbe A, Brittain K, Abrams EJ, Myer L. HIV Viremia During Pregnancy and Neurodevelopment of HIV-Exposed Uninfected Children in the Context of Universal Antiretroviral Therapy and Breastfeeding: A Prospective Study. Pediatr Infect Dis J. 2019 Jan;38(1):70-75. doi: 10.1097/INF.0000000000002193.

  PMID: 30234792 BACKGROUND

• Sauve B, Koren G, Walsh G, Tokmakejian S, Van Uum SH. Measurement of cortisol in human hair as a biomarker of systemic exposure. Clin Invest Med. 2007;30(5):E183-91. doi: 10.25011/cim.v30i5.2894.

  PMID: 17892760 BACKGROUND

• Scher MS, Loparo KA. Neonatal EEG/sleep state analyses: a complex phenotype of developmental neural plasticity. Dev Neurosci. 2009;31(4):259-75. doi: 10.1159/000216537. Epub 2009 Jan 2.

  PMID: 19546563 BACKGROUND

• Shair HN, Rupert DD, Rosko LM, Hofer MA, Myers MM, Welch MG. Effects of maternal deprivation and the duration of reunion time on rat pup ultrasonic vocalization responses to isolation: possible implications for human infant studies. Dev Psychobiol. 2015 Jan;57(1):63-72. doi: 10.1002/dev.21258. Epub 2014 Nov 7.

  PMID: 25380197 BACKGROUND

• Sheldrick RC, Perrin EC. Evidence-based milestones for surveillance of cognitive, language, and motor development. Acad Pediatr. 2013 Nov-Dec;13(6):577-86. doi: 10.1016/j.acap.2013.07.001.

  PMID: 24238685 BACKGROUND

• Spielberger CD, Vagg PR. Psychometric properties of the STAI: a reply to Ramanaiah, Franzen, and Schill. J Pers Assess. 1984 Feb;48(1):95-7. doi: 10.1207/s15327752jpa4801_16. No abstract available.

  PMID: 6707862 BACKGROUND

• Springer PE, Slogrove AL, Kidd M, Kalk E, Bettinger JA, Esser MM, Cotton MF, Zunza M, Molteno CD, Kruger M. Neurodevelopmental and behavioural outcomes of HIV-exposed uninfected and HIV-unexposed children at 2-3 years of age in Cape Town, South Africa. AIDS Care. 2020 Apr;32(4):411-419. doi: 10.1080/09540121.2019.1637506. Epub 2019 Jul 7.

  PMID: 31280587 BACKGROUND

• Strehlau R, van Aswegen T, Burke M, Kuhn L, Potterton J. A description of early neurodevelopment in a cohort of HIV-exposed uninfected children. AIDS Care. 2020 Nov;32(11):1421-1428. doi: 10.1080/09540121.2020.1736257. Epub 2020 Mar 2.

  PMID: 32122174 BACKGROUND

• Wedderburn CJ, Evans C, Yeung S, Gibb DM, Donald KA, Prendergast AJ. Growth and Neurodevelopment of HIV-Exposed Uninfected Children: a Conceptual Framework. Curr HIV/AIDS Rep. 2019 Dec;16(6):501-513. doi: 10.1007/s11904-019-00459-0.

  PMID: 31732866 BACKGROUND

• Wedderburn CJ, Yeung S, Rehman AM, Stadler JAM, Nhapi RT, Barnett W, Myer L, Gibb DM, Zar HJ, Stein DJ, Donald KA. Neurodevelopment of HIV-exposed uninfected children in South Africa: outcomes from an observational birth cohort study. Lancet Child Adolesc Health. 2019 Nov;3(11):803-813. doi: 10.1016/S2352-4642(19)30250-0. Epub 2019 Sep 9.

  PMID: 31515160 BACKGROUND

• Weinberger M, Oddone EZ, Henderson WG, Smith DM, Huey J, Giobbie-Hurder A, Feussner JR. Multisite randomized controlled trials in health services research: scientific challenges and operational issues. Med Care. 2001 Jun;39(6):627-34. doi: 10.1097/00005650-200106000-00010.

  PMID: 11404645 BACKGROUND

• Welch MG, Firestein MR, Austin J, Hane AA, Stark RI, Hofer MA, Garland M, Glickstein SB, Brunelli SA, Ludwig RJ, Myers MM. Family Nurture Intervention in the Neonatal Intensive Care Unit improves social-relatedness, attention, and neurodevelopment of preterm infants at 18 months in a randomized controlled trial. J Child Psychol Psychiatry. 2015 Nov;56(11):1202-11. doi: 10.1111/jcpp.12405. Epub 2015 Mar 11.

  PMID: 25763525 BACKGROUND

• Welch MG, Halperin MS, Austin J, Stark RI, Hofer MA, Hane AA, Myers MM. Depression and anxiety symptoms of mothers of preterm infants are decreased at 4 months corrected age with Family Nurture Intervention in the NICU. Arch Womens Ment Health. 2016 Feb;19(1):51-61. doi: 10.1007/s00737-015-0502-7. Epub 2015 Mar 1.

  PMID: 25724391 BACKGROUND

• Welch MG, Hofer MA, Brunelli SA, Stark RI, Andrews HF, Austin J, Myers MM; Family Nurture Intervention (FNI) Trial Group. Family nurture intervention (FNI): methods and treatment protocol of a randomized controlled trial in the NICU. BMC Pediatr. 2012 Feb 7;12:14. doi: 10.1186/1471-2431-12-14. Erratum In: BMC Pediatr. 2012;12:107.

  PMID: 22314029 BACKGROUND

• Welch MG, Myers MM, Grieve PG, Isler JR, Fifer WP, Sahni R, Hofer MA, Austin J, Ludwig RJ, Stark RI; FNI Trial Group. Electroencephalographic activity of preterm infants is increased by Family Nurture Intervention: a randomized controlled trial in the NICU. Clin Neurophysiol. 2014 Apr;125(4):675-684. doi: 10.1016/j.clinph.2013.08.021. Epub 2013 Oct 17.

  PMID: 24140072 BACKGROUND

• Yamada J, Stevens B, de Silva N, Gibbins S, Beyene J, Taddio A, Newman C, Koren G. Hair cortisol as a potential biologic marker of chronic stress in hospitalized neonates. Neonatology. 2007;92(1):42-9. doi: 10.1159/000100085. Epub 2007 Mar 14.

  PMID: 17356304 BACKGROUND

• Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001 Sep;16(9):606-13. doi: 10.1046/j.1525-1497.2001.016009606.x.

  PMID: 11556941 BACKGROUND

• Knowles KA, Olatunji BO. Specificity of trait anxiety in anxiety and depression: Meta-analysis of the State-Trait Anxiety Inventory. Clin Psychol Rev. 2020 Dec;82:101928. doi: 10.1016/j.cpr.2020.101928. Epub 2020 Oct 10.

  PMID: 33091745 BACKGROUND

• Achenbach, T. M. (1999). The Child Behavior Checklist and related instruments. In M. E. Maruish (Ed.), The use of psychological testing for treatment planning and outcomes assessment (pp. 429-466). Lawrence Erlbaum Associates Publishers.

  BACKGROUND

• Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983 Dec;24(4):385-96. No abstract available.

  PMID: 6668417 BACKGROUND

Study Officials

• Dani Dumitriu, MD, PhD

  Columbia University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, OUTCOMES ASSESSOR
• Masking Details: Study staff who deliver the intervention will not be blinded to participant group. Hospital staff will be blind to group status.
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Pediatrics (in Psychiatry)

Study Record Dates

• First Submitted: August 19, 2020
• First Posted: August 28, 2020
• Study Start: February 14, 2024
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2028
• Last Updated: May 28, 2025

Record last verified: 2025-05

Locations

US (1)