NCT04527939

Brief Summary

ERUS-3D and CMI demonstrated good diagnostic accuracy in parietal staging of rectal extraperitoneal neoplasms, however with greater efficiency of the endoscopic method. The association of studies can improve diagnostic efficacy and influence the most appropriate approach.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
70

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Aug 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 7, 2020

Completed
3 days until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 10, 2020

Completed
9 days until next milestone

First Submitted

Initial submission to the registry

August 19, 2020

Completed
8 days until next milestone

First Posted

Study publicly available on registry

August 27, 2020

Completed
2.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

August 7, 2023

Completed
Last Updated

August 27, 2020

Status Verified

August 1, 2020

Enrollment Period

3 days

First QC Date

August 19, 2020

Last Update Submit

August 21, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Degree of parietal invasion (T),

    Patients with Stage T after procedure

    immediately after the procedure

Study Arms (2)

three-dimensional endorectal ultrasonography

ACTIVE COMPARATOR

three-dimensional endorectal ultrasonography

Procedure: three-dimensional endorectal ultrasonography

magnification chromoendoscopy.

SHAM COMPARATOR

magnification chromoendoscopy.

Procedure: three-dimensional endorectal ultrasonography

Interventions

three-dimensional endorectal ultrasonography

magnification chromoendoscopy.three-dimensional endorectal ultrasonography

Eligibility Criteria

Age18 Years - 75 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Medicine School, Sao Paulo University

São Paulo, 05403-900, Brazil

Location

Related Publications (3)

  • Nahas SC, Nahas CSR, Bustamante-Lopez LA, Pinto RA, Marques CFS, Cecconello I. Outcomes of surgical treatment for patients with distal rectal cancer: A retrospective review from a single university hospital. Rev Gastroenterol Mex (Engl Ed). 2020 Apr-Jun;85(2):180-189. doi: 10.1016/j.rgmx.2019.05.009. Epub 2020 Feb 11. English, Spanish.

  • Kawaguti FS, Franco MC, Martins BC, Segateli V, Marques CFS, Nahas CSR, Pinto RA, Safatle-Ribeiro AV, Ribeiro-Junior U, Nahas SC, Maluf-Filho F. Role of Magnification Chromoendoscopy in the Management of Colorectal Neoplastic Lesions Suspicious for Submucosal Invasion. Dis Colon Rectum. 2019 Apr;62(4):422-428. doi: 10.1097/DCR.0000000000001343.

  • Pinto RA, Correa Neto IJ, Nahas SC, Rizkalah Nahas CS, Sparapan Marques CF, Ribeiro Junior U, Kawaguti FS, Cecconello I. Efficacy of 3-Dimensional Endorectal Ultrasound for Staging Early Extraperitoneal Rectal Neoplasms. Dis Colon Rectum. 2017 May;60(5):488-496. doi: 10.1097/DCR.0000000000000781.

MeSH Terms

Conditions

Rectal Neoplasms

Condition Hierarchy (Ancestors)

Colorectal NeoplasmsIntestinal NeoplasmsGastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesIntestinal DiseasesRectal Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Masking Details
Only investigator
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Extraperitoneal rectal cancer stage 1
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

August 19, 2020

First Posted

August 27, 2020

Study Start

August 7, 2020

Primary Completion

August 10, 2020

Study Completion

August 7, 2023

Last Updated

August 27, 2020

Record last verified: 2020-08

Data Sharing

IPD Sharing
Will not share

comparative analysis of invasion depth of extraperitoneal rectal neoplasms between three-dimensional endorectal ultrasonography and magnification chromoendoscopy.

Locations