Serum Irisin Levels in Obese Children

NCT04524936 | Completed

• 1 other identifier: I-OBESITY
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Irisin is a myokine induced by exercise, that converts white fat tissue to brown fat tissue, thereby increases thermogenesis and energy expenditure. The aim of this study is to determine the relationships between serum irisin levels and glucose and lipid parameters in obese children with and without non-alcoholic fatty liver disease (NAFLD). A total of 60 pubertal obese children (age range: 11-18 years) will be included in the study. 30 of these patients will be had NAFLD. The control group consisted of 28 healthy children who will be similar in age and sex to the obese group.

Conditions

Serum Irisin Levels in Obese Children

Keywords

irisin; obesity; children; non-alcoholic fatty liver disease

Outcome Measures

Primary Outcomes (1)

• serum irisin levels

  Serum irisin levels were measured and compared in three groups

  1 day

Study Arms (3)

obese patient with non-alcoholic fatty liver disease

Diagnostic Test: blood sample

obese patient without non-alcoholic fatty liver disease

Diagnostic Test: blood sample

control group

Diagnostic Test: blood sample

Interventions

blood sample DIAGNOSTIC_TEST

control group; obese patient with non-alcoholic fatty liver disease; obese patient without non-alcoholic fatty liver disease

Eligibility Criteria

• Age: 11 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

pubertal children

You may qualify if:

• BMI≥95.p
• Puberty
• The control group will be similar in age and sex to the obese group.

You may not qualify if:

• viral hepatitis,
• autoimmune hepatitis,
• primary sclerosing cholangitis,
• hemochromatosis,
• drug-induced liver disease,
• Wilson disease,
• α-1 antitrypsin deficiency,
• type 1 DM,
• pancreatitis,
• thyroid disease,
• renal failure,
• estrogen, progesterone, glucocorticoids, insulin, UDCA, iron, interferon, antibiotics, levothyroxine sodium, metformin, antiepileptic drug used

Sponsors & Collaborators

• Eskisehir Osmangazi University: lead

Study Sites (1)

Eskişehir Osmangazi University Faculty of Medicine

Eskişehir, Eyalet/Yerleşke, 11111, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Obesity; Non-alcoholic Fatty Liver Disease

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Fatty Liver; Liver Diseases; Digestive System Diseases

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Days
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 19, 2020
• First Posted: August 24, 2020
• Study Start: June 3, 2016
• Primary Completion: April 1, 2017
• Study Completion: April 1, 2017
• Last Updated: August 31, 2020

Record last verified: 2020-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)