Right Ventricular Function in End-stage Renal Disease Patients

NCT04524468 | Completed

• 1 other identifier: 2019-398
• Study Type: observational
• Target: 83
• Locations: 1 country
• Sites: 1

Brief Summary

Right ventricular (RV) dysfunction is a major cause of heart failure and mortality in end-stage renal disease (ESRD) patients. The aim of the study was to evaluate the long-term impacts of different dialysis modalities on RV function assessed by conventional echocardiography in ESRD patients with preserved left ventricular function. The study included 83 ESRD patients grouped as follows: peritoneal dialysis (PD; n=46) and hemodialysis with brachial arterio-venous fistula (HD; n=37). Conventional echocardiography including 2D and tissue Doppler imaging was performed in all patients. Echocardiographic parameters were compared between groups.

Conditions

Transthoracic Echocardiography; Hemodialysis

Keywords

echocardiography; hemodialysis; peritoneal dialysis; right ventricle

Outcome Measures

Primary Outcomes (1)

• Estimation of right ventricular function in end-stage renal disease patients

  Transthoracic echocardiography was performed to end-stage renal disease patients on hemodialysis and peritoneal dialysis for at least 6 months. Tricuspid annular plane systolic excursion (TAPSE), right ventricular fractional area change (RV FAC), Right ventricular myocardial performance index (RV MPI) and right ventricular lateral peak annular systolic velocity (Sa) were measured to estimate right ventricular function.

  1 week

Study Arms (2)

hemodialysis patients

end-stage renal disease patients on hemodialysis

Diagnostic Test: Transthoracic echocardiography

peritoneal dialysis patients

end-stage renal disease patients on peritoneal dialysis

Diagnostic Test: Transthoracic echocardiography

Interventions

Transthoracic echocardiography DIAGNOSTIC_TEST

Conventional 2-D transthoracic echocardiography was performed to all patients

hemodialysis patients; peritoneal dialysis patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

End-stage renal disease patients on a regular dialysis program at least 6 months

You may qualify if:

• End-stage renal disease patients on a regular dialysis program
• Being on dialysis at least 6 months
• \>18 years old

You may not qualify if:

• Ischemic heart disease
• Left ventricular systolic dysfunction with an ejection fraction (EF) of less than 55 %
• Valvulopathy
• Left bundle branch block
• Atrial fibrilation
• Previous renal transplantation
• Chronic obstructive pulmonary disease
• Interstitial lung diseases
• Connective tissue disorders
• Chronic thromboembolic disease
• Congenital left-to-right shunt
• Primary pulmonary hypertension

Sponsors & Collaborators

• Antalya Training and Research Hospital: lead

Study Sites (1)

Antalya Research and Training Hospital

Antalya, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Echocardiography

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Officials

• Duygu Ersan Demirci, MD

  Antalya Research and Training Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: August 20, 2020
• First Posted: August 24, 2020
• Study Start: January 1, 2019
• Primary Completion: March 1, 2020
• Study Completion: July 1, 2020
• Last Updated: August 26, 2020

Record last verified: 2020-08

Locations

TU (1)