Myocardial Function Assessment in Patients With Coronary Artery Disease Using Noninvasive Myocardial Work
1 other identifier
observational
130
1 country
1
Brief Summary
Noninvasive pressure-strain loop (PSL) derived myocardial work (MW) are more sensitive than conventional echocardiographic parameters in quantitative assessment of early myocardial dysfunction. The aim of this study was to assess left ventricular (LV) myocardial function in symptomatic patients with coronary artery disease using the promising method. Methods: Transthoracic echocardiography was performed on patients with angina or equivalent symptoms before coronary angiography. Images were stored and imported into the software for further offline analysis of PSL-based MW. MW analysis were carried out on each patient for global and regional myocardial function assessment.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Oct 2021
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2021
CompletedFirst Submitted
Initial submission to the registry
May 16, 2023
CompletedFirst Posted
Study publicly available on registry
May 25, 2023
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2023
CompletedMay 25, 2023
April 1, 2023
1.7 years
May 16, 2023
May 24, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
myocardial function
noninvasive myocardial work indices
baseline (before coronary angiography)
Study Arms (2)
nonsignificant coronary artery stenosis group
Exclusion criteria: ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography
significant coronary artery stenosis group
Defined as ≥70% proximal luminal stenosis in at least one major coronary vessel based on coronary angiography
Interventions
noninvasive myocardial work
Eligibility Criteria
Patients who were hospitalized for coronary angiography with angina or equivalent symptoms.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, 510120, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Yingmei Liu
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 16, 2023
First Posted
May 25, 2023
Study Start
October 1, 2021
Primary Completion
June 1, 2023
Study Completion
June 1, 2023
Last Updated
May 25, 2023
Record last verified: 2023-04
Data Sharing
- IPD Sharing
- Will not share