Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

NCT04520763 | Completed

• 1 other identifier: HOGTT_2020
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.

Conditions

Healthy Aging; Healthy Diet

Outcome Measures

Primary Outcomes (2)

• Peak blood glucose concentration

  Peak blood glucose concentration will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).

  throughout the study, an expected average of 2 weeks per participant

• area under the glucose-time curve

  Area under the glucose-time curve will be determined in the three conditions (5min or 15min respiratory muscle exercises or control).

  throughout the study, an expected average of 2 weeks per participant

Study Arms (2)

Respiratory Muscle Exercises

EXPERIMENTAL

Two respiratory muscle exercises

Other: 5min respiratory muscle exercises; Other: 15min respiratory muscle exercises

Control

NO INTERVENTION

The control intervention consists of quiet sitting for 15 min

Interventions

5min respiratory muscle exercises OTHER

5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose

Respiratory Muscle Exercises

15min respiratory muscle exercises OTHER

5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose

Respiratory Muscle Exercises

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥18 years
• Healthy
• Non-smoking
• Body mass index (BMI): 18.5 - 29.9 kg∙m-2
• Normal lung function
• Willing to adhere to study rules

You may not qualify if:

• Known or suspected non-compliance, drug or alcohol abuse
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
• Previous enrolment into the current study
• Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
• Pregnancy, breastfeeding, or intention to become pregnant during the study

Sponsors & Collaborators

• Swiss Federal Institute of Technology: lead

Study Sites (1)

Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

Zurich, Canton of Zurich, 8057, Switzerland

Location

Study Officials

• Christin M. Spengler, Prof.

  Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This study consists of four visits to the laboratory, each separated by at least 24 hours and each lasting approximately 2.5h. Total duration for each participant is approximately 2 weeks. The study is conducted in 40 healthy adults (≥ 18 years). The study is a randomized, controlled cross-over trial. We chose a cross-over design in order to test the effects of different respiratory exercises compared to a control intervention in order to minimize variability since each subject serves as his/her own control. Due to the nature of the intervention (respiratory muscle exercises), it is not possible to blind participants to the interventions.

Study Record Dates

• First Submitted: August 17, 2020
• First Posted: August 20, 2020
• Study Start: August 20, 2020
• Primary Completion: April 21, 2022
• Study Completion: April 21, 2022
• Last Updated: March 17, 2023

Record last verified: 2023-03

Locations

CH (1)