Kharituwe TB Contact Tracing Study
Innovative Contact Tracing Strategies for Detecting TB in Mobile Rural and Urban South African Populations
2 other identifiers
interventional
10,579
1 country
2
Brief Summary
The purpose of this study is to characterize the role of human mobility in fueling TB epidemics and estimate the potential impact of innovative case finding interventions tailored to mobile populations
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Sep 2020
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 7, 2020
CompletedFirst Posted
Study publicly available on registry
August 20, 2020
CompletedStudy Start
First participant enrolled
September 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 30, 2023
CompletedResults Posted
Study results publicly available
February 10, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2025
CompletedApril 8, 2025
April 1, 2025
3 years
August 7, 2020
November 26, 2024
April 1, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Effectiveness: Mean Number of Secondary TB Cases Identified and Started on Treatment Per Index Case in Each Arm
The mean number of secondary TB cases identified and started on treatment per index case for each arm.
Up to 35 months
Secondary Outcomes (7)
The TB Prevalence Ratio, Comparing Highly Mobile to Less Mobile Index Patients
Duration of study (30 months)
TB Strain Relatedness Using Maximum Likelihood Transmission Trees.
Duration of study (30 months)
Relative Acceptability of Each Novel Strategy Compared to Standard Contact Investigation
Duration of study (30 months)
Feasibility of Each Strategy: Proportion of Potentially Eligible Index Cases for Whom a Household Visit Was Conducted
Duration of study (30 months(
Relative Fidelity of Each Novel Strategy Compared to Standard Contact Investigation
Duration of study (30 months)
- +2 more secondary outcomes
Study Arms (3)
Standard Tracing
ACTIVE COMPARATORHouseholds of tuberculosis index patients receive "standard" household contact tracing during regular weekday business hours.
Holiday Tracing
EXPERIMENTALHouseholds of tuberculosis index patients in rural South Africa receive household contact tracing during holidays (Christmas and Easter).
Evening / Weekend Tracing
EXPERIMENTALHouseholds of tuberculosis index patients in urban South Africa receive household contact tracing during evenings and weekends.
Interventions
Household contact tracing to test and diagnose Tuberculosis of household contacts of Tuberculosis patients.
Eligibility Criteria
You may qualify if:
- Age 0-99 years (Including those recently deceased)
- Diagnosed with pulmonary TB at a study hospital or clinic (microbiological and/or chest x-ray diagnosis)
You may not qualify if:
- Unwilling/unable to provide informed consent (including next of kin, for those recently deceased)
- Plan not to pursue TB treatment within the study district
- Unwilling/unable to comply with study procedures
- Contacts:
- Age 0-99 years
- Currently resides with or visiting eligible TB index case
- Unwilling/unable to provide informed consent
- Unwilling/unable to comply with study procedures
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Perinatal HIV Research Unit (PHRU)
Johannesburg, South Africa
Setshaba Research Centre
Soshanguve, South Africa
Related Publications (3)
Hanrahan CF, Nonyane BAS, Biche P, Mohlamonyane M, Morolo M, Omar SV, Ahmed K, Martinson N, Dowdy DW. Timing of household contact investigation for tuberculosis among rural and urban populations in South Africa (Kharituwe study): a pragmatic individually randomized controlled trial. EClinicalMedicine. 2026 Jan 16;91:103744. doi: 10.1016/j.eclinm.2025.103744. eCollection 2026 Jan.
PMID: 41607590DERIVEDYoung N, Biche P, Mohlamonyane M, Morolo M, Maholwana B, Ahmed K, Martinson N, Hanrahan CF, Dowdy DW. Innovative timing strategies for tuberculosis household contact investigation: cost-effectiveness analysis from a randomized trial in rural and urban South Africa (Kharituwe Study). EClinicalMedicine. 2025 May 26;84:103259. doi: 10.1016/j.eclinm.2025.103259. eCollection 2025 Jun.
PMID: 40503514DERIVEDMlambo LM, Milovanovic M, Hanrahan CF, Motsomi KW, Morolo MT, Mohlamonyane MP, Albaugh NW, Ahmed K, Martinson NA, Dowdy DW, West NS. The impact of ethical implications intertwined with tuberculosis household contact investigation: a qualitative study. medRxiv [Preprint]. 2024 Jun 28:2024.06.27.24309538. doi: 10.1101/2024.06.27.24309538.
PMID: 38978659DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Results Point of Contact
- Title
- Dr. Colleen Hanrahan
- Organization
- Johns Hopkins Bloomberg School of Public Health
Study Officials
- PRINCIPAL INVESTIGATOR
David W. Dowdy, MD, PhD
Johns Hopkins Bloomberg School of Public Health
Publication Agreements
- PI is Sponsor Employee
- No
- Restrictive Agreement
- No
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Masking Details
- The principal investigators are blinded as to the assignment of treatment to participants
- Purpose
- DIAGNOSTIC
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 7, 2020
First Posted
August 20, 2020
Study Start
September 1, 2020
Primary Completion
August 30, 2023
Study Completion
March 31, 2025
Last Updated
April 8, 2025
Results First Posted
February 10, 2025
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will not share