Sing for Your Saunter - Dementia Supplement

NCT04518917 | Completed Results DMC

• 1 other identifier: AT010753-02S1
• Study Type: interventional
• Target: 17
• Locations: 1 country
• Sites: 1

Brief Summary

Older adults, and particularly those with Parkinson disease (PD), may experience walking difficulties that negatively impact their daily function and quality of life. People that have PD plus dementia are also likely to experience walking difficulties. This project will examine the impact of music and mentally singing on walking performance, with a goal of understanding what types of rhythmic cues are most helpful. Pilot work from the investigators suggests that imagined, mental singing (i.e., singing in head) while while walking helps people walk faster with greater stability, whereas walking to music also helps people walk faster but with reduced stability. In this study, the investigators will recruit people who have PD plus dementia. The investigators will compare walking while mentally singing and walking while listening to music, using personalized cues tailored to each person's walking performance. The investigators hypothesize temporal variability of gait will be lower in the mental singing and singing conditions compared to listening to music; and that mental singing, singing, and listening to music will elicit similar improvements in stride length.

Conditions

Parkinson Disease; Parkinson Disease Dementia

Keywords

Parkinson disease; Music; Mental singing; Gait

Outcome Measures

Primary Outcomes (2)

• Velocity

  Measured with wearable sensors by APDM Wearable Technology

  Baseline

• Stride Length

  Measured with wearable sensors by APDM Wearable Technology

  Baseline

Study Arms (1)

Parkinson disease plus dementia

OTHER

Participants will have a diagnosis of Parkinson disease plus dementia.

Behavioral: Mentally Singing; Behavioral: Listening to music

Interventions

Mentally Singing BEHAVIORAL

Participants sing their song in their head and match their footfalls to the beat.

Parkinson disease plus dementia

Listening to music BEHAVIORAL

Participants listen to their song and match their footfalls to the beat.

Parkinson disease plus dementia

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• at least 30 years of age
• diagnosis of idiopathic, typical Parkinson disease according to the UK Brain Bank Criteria
• Hoehn \& Yahr stages 2-3 (mild to moderate disease severity)
• normal or corrected hearing
• stable on all PD medications for at least 2 months prior to study entry
• dementia as defined by a Clinical Dementia Rating (CDR) score of 0.5-1.0 (very mild to mild dementia)
• score of ≥ 1 on the MDS-UPDRS-III Item #10 indicating observable gait impairment
• a score of 1 or less on item #7 on the freezing of gait questionnaire
• able to walk for 10 continuous minutes independently

You may not qualify if:

• diagnosis of any other neurological condition
• unstable medical or concomitant illnesses or psychiatric conditions which, in the opinion of the investigators, would preclude successful participation
• cardiac problems that interfere with ability to safely participate (i.e., uncontrolled congestive heart failure, myocardial infarction in past 6 months, complex cardiac arrhythmias, significant left ventricular dysfunction, dyspnea on exertion, chest pain or pressure, resting tachycardia (\>100 beats/min); uncontrolled BP (resting systolic BP \>160 mmHg or diastolic BP \>100 mmHg))
• orthopedic problems in the lower extremities or spine that may limit walking (i.e., severe arthritis, spinal stenosis)
• uncontrolled tremor or dyskinesia while on PD medications

Sponsors & Collaborators

• Washington University School of Medicine: lead

Study Sites (1)

Washington University School of Medicine Program in Physical Therapy

St Louis, Missouri, 63110, United States

Location

MeSH Terms

Conditions

Parkinson Disease

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Results Point of Contact

• Title: Gammon Earhart
• Organization: Washington University in St. LOuis

earhartg@wustl.edu

314-286-1407

Study Officials

• Gammon Earhart

  Washington University School of Medicine

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director, Program in Physical Therapy

Study Record Dates

• First Submitted: August 15, 2020
• First Posted: August 19, 2020
• Study Start: April 19, 2021
• Primary Completion: May 15, 2023
• Study Completion: May 15, 2023
• Last Updated: January 9, 2025
• Results First Posted: January 9, 2025

Record last verified: 2024-11

Locations

US (1)