The restrictions on research imposed for the COVID-19 pandemic prevented us from launching study recruitment and visits. At this stage our funding is not sufficient to allow us to enroll sufficient numbers of patients so we will close the study.
SOFA
Sponsor study identifier
Secondary identifiers
observational
0
1 country
1
Study Start
February 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
February 9, 2023
Actual (reported)Study Completion
February 9, 2023
Actual (reported)This is a single center study of 60 subjects including those with asthma and mucus plugging, those with asthma and without mucus plugging, and healthy controls. Screening data will be reviewed to determine participant eligibility. Participants who meet all inclusion criteria will participate in image-guided bronchoscopy ("virtual navigation bronchoscopy" \[VNB\]) to sample airway biospecimens in mucus plugged and control airways.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
February 9, 2023
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
August 12, 2020
Actual (reported)August 17, 2020
Actual (reported)February 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
February 9, 2023
Actual (reported)February 9, 2023
Actual (reported)Difference in eosinophil percentage in broncheoalveolar biospecimens between asthmatic and non-asthmatic airways
The investigators will examine differences in type-2 inflammatory markers in bronchoalveolar biospecimens. Eosinophils are an indicator of type 2 inflammation in bronchial lavage samples. Indicators of airway inflammation will be compared with healthy control biospecimens and those of non-mucus plugged asthmatics.
6 months
Difference in gene expression of genes that mark IL-13 activation between asthmatic and non-asthmatic airways
Genes such as periostin, CLCA1, and Serpin B2 will be analyzed for expression in epithelial cell brushings.
6 months
Participants with no history of asthma or other lung diseases.
Participants with asthma and no evidence of mucus plugging.
Participants with asthma and evidence by MDCT lung scan showing mucus plugging.
This is a low-dose CT scan of the chest using no contract material.
This is a procedure where a camera will be inserted into the lung in order to guide sample collection of bronchoalveolar lavages, bronchail brushes and endobronchial biopsies.
Participants with asthma who present with or without mucus plugs, as well as healthy controls, all between the ages of 18 and 70.
UCSF Airway Clinical Research Center
San Francisco, California, 94143, United States
bronchoalveolar lavage from airways in 1-2 bronchopulmonary segments, bronchial brushes from airways in 2-3 bronchopulmonary segments, endobronchial biopsies from airways in 2-3 bronchopulmonary segments, and blood.
John Fahy, MD, MSc
University of California, San Francisco
0 participants (actual enrollment reported by the registry).
First Submitted
August 12, 2020
First Posted
August 17, 2020
Study Start
February 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The Effect of NAC on Lung Function and CT Mucus Score
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Contact the study team to confirm eligibility.
Primary Completion
February 9, 2023
Actual (reported)Study Completion
February 9, 2023
Actual (reported)Last Updated
March 6, 2026
Record last verified: 2026-03
There is no plan to make IPD available to other researchers.
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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