Heart Rate Variability and Postoperative Nausea Vomiting

NCT04514211 | Completed

• 1 other identifier: AJIRB-MED-OBS-20-293
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Propofol and sevoflurane have different effects on heart rate variability. It has not yet been reported whether this difference in effect remains at recovery time after anesthesia and the difference is related to postoperative nausea and vomiting has not been studied. The aim of this study is observe whether propofol and sevoflurane have different effects on heart rate variability during recovery and the differences can predict the occurrence of postoperative nausea and vomiting.

Conditions

Postoperative Nausea and Vomiting

Keywords

postoperative nausea and vomiting; heart rate variability; propofol; sevoflurane

Outcome Measures

Primary Outcomes (1)

• heart rate variability in recovery room

  Postoperative heart rate variability measuring at recovery room Frequency domain result: total power, low frequency power, high frequency power, Low frequency/high frequency power ratio

  within 1 hour

Secondary Outcomes (3)

• Postoperative nausea vomiting impact scale

  48 hours after anesthesia

• The incidence of postoperative nausea and vomiting

  48 hours after anesthesia

• Patient's satisfaction about postoperative nausea and vomiting

  48 hours after anesthesia

Study Arms (2)

Propofol

General anesthesia using propofol infusion

Drug: Propofol

Sevoflurane

General anesthesia using sevoflurane

Drug: Sevoflurane

Interventions

Propofol DRUG

General anesthesia using propofol infusion

Also known as: Propofol infusion

Propofol

Sevoflurane DRUG

General anesthesia using sevoflurane

Also known as: Sevoflurane inhalation

Sevoflurane

Eligibility Criteria

• Age: 20 Years - 50 Years
• Gender Eligibility Details: Include only mathces self-representation of gender identity and biological sex
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

20\~50 years old female patients who scheduled breast surgery under general anesthesia

You may qualify if:

• Scheduled breast surgery under general anesthesia

You may not qualify if:

• Arrhythmia
• Uncooperative with the measuring heart rate variability
• Diabetes
• Hypertension on medication
• Patients taking psychiatric drugs
• Thyroid disease

Sponsors & Collaborators

• Ajou University School of Medicine: lead

Study Sites (1)

Ajou university school of medicine

Suwon, Gyeonggi-do, 16499, South Korea

Location

MeSH Terms

Conditions

Postoperative Nausea and Vomiting

Interventions

Propofol; Sevoflurane

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Nausea; Signs and Symptoms, Digestive; Signs and Symptoms; Vomiting

Intervention Hierarchy (Ancestors)

Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons; Organic Chemicals; Methyl Ethers; Ethers; Hydrocarbons, Fluorinated; Hydrocarbons, Halogenated

Study Officials

• In Kyong Yi, MD

  Ajou University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: August 12, 2020
• First Posted: August 14, 2020
• Study Start: October 17, 2020
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: February 18, 2022

Record last verified: 2022-02

Locations

KR (1)