NCT04466046|Completed
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Sponsor study identifier
observational
68
1 country
1
Study Start
September 4, 2019
Actual (reported)Primary Completion
June 30, 2020
Actual (reported)Study Completion
June 30, 2020
Actual (reported)Nausea and vomiting after surgery are one of the complications that occur after general anesthesia, and the frequency is reported to range from 10% to 80% in the high-risk group. Several studies have introduced drugs and methods to prevent nausea and vomiting after surgery. Among them, midazolam administered before surgery is known to have anti-anxiolytic and sedative effects on the prevention of nausea and vomiting after surgery. It has also been reported to increase its effectiveness when administered with other antiemetic agents. The purpose of this study is to compare the effects of administration of combination with midazolam and different antiemetic agents on the prevention of postoperative nausea and vomiting in high-risk patients.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
June 30, 2020
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
September 4, 2019
Actual (reported)June 30, 2020
Actual (reported)June 30, 2020
Actual (reported)July 2, 2020
Actual (reported)July 10, 2020
Actual (reported)percentage of patients receiving ramosetron or palonosetron in each groups
percentage of patients receiving ramosetron or palonosetron
48 hours after surgery
severity of postoperative nausea in PONV group
0 = none, 1 = mild, 2 = moderate, 3 = severe
48 hours after surgery
postoperative pain
48 hours after surgery
Patients with PONV after administration of midazolam 0.05mg/kg with ramosetron 0.3mg or palonosetron 0.075mg
Patients with no PONV after administration of midazolam 0.05mg/kg with ramosetron 0.3mg or palonosetron 0.075mg
female patients aged 20 to 65 with ASA physical status 1 or 2 undergoing laparoscopic cholecystectomy
Daegu Catholic University Medical Center
Daegu, Nam-gu, 42472, South Korea
Jung A Lim, MD
Daegu Catholic University Medical Center
68 participants (actual enrollment reported by the registry).
First Submitted
July 2, 2020
First Posted
July 10, 2020
Study Start
September 4, 2019
Actual (reported)The efficacy of aprepitant for the prevention of postoperative nausea and vomiting after bariatric surgery.
Contact the study team to confirm eligibility.
Primary Completion
June 30, 2020
Actual (reported)Study Completion
June 30, 2020
Actual (reported)Last Updated
November 2, 2022
Record last verified: 2022-10
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Source: ClinicalTrials.gov.
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