Difference in Central Fatigue During Two Ultra-endurance Practices: Running vs. Cycling

NCT04511858 | Completed

• 2 other identifiers: 19CH2172020-A01714-35
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The mechanisms contributing to muscle fatigue in extreme long-duration exercise bouts are poorly understood. Ultra-endurance exercise is an excellent model for the study of adaptive responses to extreme loads and stress and it is an especially useful model for documenting the origins of central fatigue. This protocol will compare fatigue during and after ultra-endurance exercise bouts that result in moderate lower-limb tissue damage (i.e. cycling) or significant damage (i.e. running). The results of this protocol will allow us to further understanding of the reasons for major central fatigue, i.e. within the central nervous system, in ultra-endurance.

Conditions

Ultra-marathon Runners

Keywords

central fatigue; peripheral fatigue; ultra-endurance exercise; corticospinal excitability

Outcome Measures

Primary Outcomes (1)

• Maximum level of voluntary activation of relative central fatigue

  measured in isometric mode of the knee extensors, between the value before and immediately after a 5-hour cycling or running event at the same relative intensity

  Before and immediately after 5h exercise

Secondary Outcomes (18)

• Maximum level of voluntary activation of fatigue centrale absolute

  Before and immediately after 5h exercise

• Maximum level of voluntary activation with electrical evoked activation

  Before and immediately after 5h exercise

• Spinal excitability

  Before and immediately after 5h exercise

• Corticospinal excitability

  Before and immediately after 5h exercise

• Cortical excitability

  Before and immediately after 5h exercise

Study Arms (2)

Running endurance

EXPERIMENTAL

Athletes wiil run for 5 hours in a row.

Other: maximum effort test on a treadmill

Cycling endurance

EXPERIMENTAL

Athletes wiil cycle for 5 hours in a row.

Other: maximum effort test on a cycloergometer

Interventions

maximum effort test on a cycloergometer OTHER

5 h test on cycloergometer

Cycling endurance

maximum effort test on a treadmill OTHER

5 h test on treadmill

Running endurance

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Specialist in endurance and ultra-endurance. in the 2 disciplines: running and cycling (triathletes, duathletes or trailers achieving at least 30% of their training volume in cycling), and having at least finished one long distance event in the last 2 years,
• Affiliated or beneficiary of a social security scheme.
• Signature of the consent form

You may not qualify if:

• Any subject who has been injured in the 3 months prior to the protocol
• Anyone with chronic joint pathologies (e.g.: repetitive sprains, patellar or ligament problems).
• Any subject with chronic or central neurological pathologies
• Any subject with a contraindication to magnetic stimulation
• Use of neuro-active substances likely to alter cortico-spinal excitability (hypnotics, antiepileptics, psychotropic drugs, muscle relaxants) on the study.
• Contraindication to the application of a magnetic field:
• Heart or respiratory insufficiency.
• Subject with a cardiac pace maker.
• Cardiac valve wear and serious cardiovascular diseases.
• Presence of prosthetic material or ferromagnetic foreign bodies in the head.
• Presence of cochlear implants or ocular prosthetic material.
• History of neurosurgical interventions.
• Neurological diseases that may affect brain structures and cognitive abilities (e.g., intracranial tumour, multiple sclerosis, history of stroke or traumatic brain injury).
• History of comitiality, contralateral knee disease or musculoskeletal disease.
• Any subject participating at the same time in another interventional experiment requiring physical exercise.

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU Saint-Etienne

Saint-Etienne, 42000, France

Location

Study Officials

• Léonard FEASSON, MD PhD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

• Guillaume MILLET, PhD

  SAINT-ETIENNE UNIVERSITY

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Prospective study of physiopathology on subjects specializing in endurance and ultra-endurance: comparing running vs. cycling. Cross-over: each subject will carry out the 2 experimental conditions (running and cycling) according to a randomized order of passage, respecting a wash-out of 2 weeks.

Study Record Dates

• First Submitted: July 31, 2020
• First Posted: August 13, 2020
• Study Start: March 5, 2021
• Primary Completion: May 28, 2021
• Study Completion: July 15, 2021
• Last Updated: November 24, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)