Fatigability Compared Men and Women Induced According to the Distance Traveled on an Ultra-marathon in the Mountains

NCT04025138 | Completed

• 2 other identifiers: 19CH0602019-A00736-51
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Acute physiological consequences of ultra-marathon running are still unknown, particularly in women. Some studies have suggested that the proportion of fatigue attributable to peripheral and central mechanisms varies between males and females; however, results are contradictory. The results from the investigators of the present experiment in two studies conducted in 2009 and 2012 showed that:

• A large part of fatigue induced by a mountain ultra-marathon could be attributed to central fatigue in males and that,
• Females exhibited less peripheral fatigue in the plantar flexors than males did after a 110-km ultra-trail-running race. According to the literature, there seems to be a plateau in fatigue after 12-15 hours of running.

Conditions

Ultra-marathon Runners

Keywords

Sex differences; Ultra-endurance running; Mont Blanc Ultra Trail; Transcranial Magnetic Stimulation (TMS); Neuromuscular tests; Plantar flexors; Knee extensors; Force/Velocity Profile (FVP)

Outcome Measures

Primary Outcomes (1)

• Variation (%) of the amplitudes of the electric shock

  Measured by the electrically evoked force after contraction in isometric mode of the plantar flexors

  5 or 6 day before the race and 1 hour after

Secondary Outcomes (19)

• Voluntary maximum forces plantar flexors

  5 or 6 day before the race and 1 hour after

• Voluntary maximum forces knee extensors

  5 or 6 day before the race and 1 hour after

• Electrically evoked forces

  5 or 6 day before the race and 1 hour after

• ElectroMyoGraphic activity (EMG)

  5 or 6 day before the race and 1 hour after

• Three-Modality Evoked Potentials (TMEPs)

  5 or 6 day before the race and 1 hour after

Study Arms (4)

female subjects involved in races over 100 km (F>100)

EXPERIMENTAL

Female subjects involved in races over 100 km (F\>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Other: Neuromuscular tests in isometric mode; Device: Transcranial Magnetic Stimulation (TMS); Other: Neuromuscular fatigue assessment test; Other: treadmill; Biological: Blood sample; Biological: Urinary sample

female subjects involved in races less than 60 km (F<60)

EXPERIMENTAL

Female subjects involved in races less than 60 km (F\<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Other: Neuromuscular tests in isometric mode; Device: Transcranial Magnetic Stimulation (TMS); Other: Neuromuscular fatigue assessment test; Other: treadmill; Biological: Blood sample; Biological: Urinary sample

male subjects involved in races over 100 km (H>100)

EXPERIMENTAL

Male subjects involved in races over 100 km (H\>100) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Other: Neuromuscular tests in isometric mode; Device: Transcranial Magnetic Stimulation (TMS); Other: Neuromuscular fatigue assessment test; Other: treadmill; Biological: Blood sample; Biological: Urinary sample

male subjects involved in races less than 60 km (H<60)

EXPERIMENTAL

Male subjects involved in races less than 60 km (H\<60) will be included. They will have neuromuscular tests in isometric mode, Transcranial Magnetic Stimulation (TMS), neuromuscular fatigue assessment test, treadmill, blood sample and urinary sample.

Other: Neuromuscular tests in isometric mode; Device: Transcranial Magnetic Stimulation (TMS); Other: Neuromuscular fatigue assessment test; Other: treadmill; Biological: Blood sample; Biological: Urinary sample

Interventions

Neuromuscular tests in isometric mode OTHER

Protocol for neuromuscular tests in isometric mode will be assessed by the composite of these measures : * Voluntary maximum forces plantar flexors and knee extensors * Electrically evoked forces * ElectroMyoGraphic activity (EMG) * Three-Modality Evoked Potentials (TMEPs)

female subjects involved in races less than 60 km (F<60); female subjects involved in races over 100 km (F>100); male subjects involved in races less than 60 km (H<60); male subjects involved in races over 100 km (H>100)

Transcranial Magnetic Stimulation (TMS) DEVICE

Measure of supraspinal activation level and cortical excitation by Transcranial Magnetic Stimulation (TMS).

female subjects involved in races less than 60 km (F<60); female subjects involved in races over 100 km (F>100); male subjects involved in races less than 60 km (H<60); male subjects involved in races over 100 km (H>100)

Neuromuscular fatigue assessment test OTHER

Neuromuscular fatigue assessment test in dynamic mode will be assessed by the Force/Velocity Profile (FVP) measure: 2 sprints of 8 seconds on a cycle ergometer.

female subjects involved in races less than 60 km (F<60); female subjects involved in races over 100 km (F>100); male subjects involved in races less than 60 km (H<60); male subjects involved in races over 100 km (H>100)

treadmill OTHER

2 sessions of treadmill will be realized: 8 and 10 km.h-1 for level running and 7 km.h-1 with 10% slope for graded running.

female subjects involved in races less than 60 km (F<60); female subjects involved in races over 100 km (F>100); male subjects involved in races less than 60 km (H<60); male subjects involved in races over 100 km (H>100)

Blood sample BIOLOGICAL

Blood sample will be realized to measure hemorrheologic and hematologic parameters.

female subjects involved in races less than 60 km (F<60); female subjects involved in races over 100 km (F>100); male subjects involved in races less than 60 km (H<60); male subjects involved in races over 100 km (H>100)

Urinary sample BIOLOGICAL

Urinary sample will be realized to measure hemorrheologic and hematologic parameters.

female subjects involved in races less than 60 km (F<60); female subjects involved in races over 100 km (F>100); male subjects involved in races less than 60 km (H<60); male subjects involved in races over 100 km (H>100)

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Subject listed in the race "2019 Mont Blanc Ultra Trail"
• Affiliates or beneficiaries of social security scheme
• Signed consent

You may not qualify if:

• Subject having been injured in the previous 3 months
• Pregnant woman
• Chronic joint diseases
• Chronic or central neurological pathologies
• Taking neuroactive substances that can alter corticospinal excitability
• Contraindication to experimental procedures including Transcranial Magnetic Stimulation (TMS)
• Taking corticosteroids in the previous 3 months

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Saint Etienne: lead

Study Sites (1)

CHU Saint-Etienne

Saint-Etienne, France

Location

Related Publications (7)

• Robert M, Stauffer E, Nader E, Skinner S, Boisson C, Cibiel A, Feasson L, Renoux C, Robach P, Joly P, Millet GY, Connes P. Impact of Trail Running Races on Blood Viscosity and Its Determinants: Effects of Distance. Int J Mol Sci. 2020 Nov 12;21(22):8531. doi: 10.3390/ijms21228531.

  PMID: 33198320 RESULT

• Temesi J, Besson T, Parent A, Singh B, Martin V, Brownstein CG, Espeit L, Royer N, Rimaud D, Lapole T, Feasson L, Millet GY. Effect of race distance on performance fatigability in male trail and ultra-trail runners. Scand J Med Sci Sports. 2021 Sep;31(9):1809-1821. doi: 10.1111/sms.14004. Epub 2021 Jul 12.

  PMID: 34170574 RESULT

• Foure A, Besson T, Stauffer E, Skinner SC, Bouvier J, Feasson L, Connes P, Hautier CA, Millet GY. Sex-related differences and effects of short and long trail running races on resting muscle-tendon mechanical properties. Scand J Med Sci Sports. 2022 Oct;32(10):1477-1492. doi: 10.1111/sms.14203. Epub 2022 Jul 6.

  PMID: 35730335 RESULT

• Pastor FS, Besson T, Varesco G, Parent A, Fanget M, Koral J, Foschia C, Rupp T, Rimaud D, Feasson L, Millet GY. Performance Determinants in Trail-Running Races of Different Distances. Int J Sports Physiol Perform. 2022 Jun 1;17(6):844-851. doi: 10.1123/ijspp.2021-0362. Epub 2022 Feb 25.

  PMID: 35213820 RESULT

• Sabater Pastor F, Varesco G, Besson T, Koral J, Feasson L, Millet GY. Degradation of energy cost with fatigue induced by trail running: effect of distance. Eur J Appl Physiol. 2021 Jun;121(6):1665-1675. doi: 10.1007/s00421-021-04624-5. Epub 2021 Mar 5.

  PMID: 33666727 RESULT

• Trama R, Blache Y, Hintzy F, Rossi J, Millet GY, Hautier C. Does neuromuscular fatigue generated by trail running modify foot-ground impact and soft tissue vibrations? Eur J Sport Sci. 2023 Jul;23(7):1155-1163. doi: 10.1080/17461391.2022.2093649. Epub 2022 Jul 10.

  PMID: 35730761 DERIVED

• Besson T, Parent A, Brownstein CG, Espeit L, Lapole T, Martin V, Royer N, Rimaud D, Sabater Pastor F, Singh B, Varesco G, Rossi J, Temesi J, Millet GY. Sex Differences in Neuromuscular Fatigue and Changes in Cost of Running after Mountain Trail Races of Various Distances. Med Sci Sports Exerc. 2021 Nov 1;53(11):2374-2387. doi: 10.1249/MSS.0000000000002719.

  PMID: 34107510 DERIVED

MeSH Terms

Interventions

Transcranial Magnetic Stimulation; Exercise Test; Blood Specimen Collection

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics; Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques; Specimen Handling; Clinical Laboratory Techniques; Punctures; Surgical Procedures, Operative

Study Officials

• Léonard FEASSON, MD PhD

  CHU SAINT-ETIENNE

  PRINCIPAL INVESTIGATOR

• Guillaume MILLET, PhD

  University of Saint-Etienne

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2019
• First Posted: July 18, 2019
• Study Start: July 2, 2019
• Primary Completion: September 1, 2019
• Study Completion: September 1, 2019
• Last Updated: December 15, 2022

Record last verified: 2022-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)