Quantitation of Glymphatic Functioning in Sleep and Meditative States

NCT04506892 | Completed

• 1 other identifier: RFA-AT-21-001
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

This involves development and application of magnetic resonance imaging (MRI) methods for visualizing hemodynamic and metabolic relationships in healthy volunteers with advanced meditation experience.

Conditions

Parkinson Disease; Sleep

Keywords

glymphatic system; meditation

Outcome Measures

Primary Outcomes (1)

• CSF flow change

  Using MRI to assess the change in CSF flow in awake, sleep deprived, and meditative states

  baseline to 24 hours

Secondary Outcomes (1)

• EEG changes

  baseline to 24 hours

Study Arms (1)

Adept Meditators

EXPERIMENTAL

Subjects will undergo scanning during awake, sleep deprived, and meditative states of consciousness.

Behavioral: Meditation

Interventions

Meditation BEHAVIORAL

meditation

Adept Meditators

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Ages 14-45
• "Adept meditator status"

You may not qualify if:

• Any non-MR compatible material implant, or contraindication to MR scanning
• Claustrophobia or inability to lie still for prolonged periods of time
• Participants with a recent (less than 2 months) infection, tattoo, or wound
• No consumption of stimulants or alcohol within 12 hours of the study visit
• clinical diagnosis of any major neurological or psychological condition
• Taking benzodiazepines, cholinestorase inhibitors, anti-psychotics, opioids, MAO inhibitors

Sponsors & Collaborators

• Vanderbilt University Medical Center: lead

Study Sites (1)

Vanderbilt University Medical Center

Nashville, Tennessee, 37212-3160, United States

Location

MeSH Terms

Conditions

Parkinson Disease

Interventions

Meditation

Condition Hierarchy (Ancestors)

Parkinsonian Disorders; Basal Ganglia Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Movement Disorders; Synucleinopathies; Neurodegenerative Diseases

Intervention Hierarchy (Ancestors)

Mind-Body Therapies; Complementary Therapies; Therapeutics; Spiritual Therapies; Relaxation Therapy; Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Study Officials

• Daniel Claassen, MD

  Vanderbilt University Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: no masking is used in this protocol
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: July 17, 2020
• First Posted: August 10, 2020
• Study Start: February 1, 2021
• Primary Completion: December 1, 2024
• Study Completion: December 1, 2024
• Last Updated: August 6, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)