NCT03198039

Brief Summary

The primary purpose of this trial is to test the feasibility of implementing a meditation program in the perioperative period.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
29

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Nov 2017

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 20, 2017

Completed
3 days until next milestone

First Posted

Study publicly available on registry

June 23, 2017

Completed
5 months until next milestone

Study Start

First participant enrolled

November 28, 2017

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2020

Completed
Last Updated

June 4, 2024

Status Verified

June 1, 2024

Enrollment Period

2.4 years

First QC Date

June 20, 2017

Last Update Submit

June 1, 2024

Conditions

Keywords

MeditationCognitive DysfunctionPostoperative PeriodCardiac Surgery

Outcome Measures

Primary Outcomes (1)

  • Adherence to implementing a meditation program in the perioperative period

    In this descriptive, feasibility study, evaluation of feasibility will include adherence to meditation intervention (total number of sessions completed).

    Baseline through 1 month post surgery

Secondary Outcomes (6)

  • Cognitive function - MoCA

    Baseline and hospital discharge (approximately 5 days)

  • Pain scores

    Postoperative Day 1 through hospital discharge (approximately 5 days)

  • Total Opioid Consumption

    Intraoperatively through 48 hours postoperatively

  • Changes in Sleep - PSQI

    Baseline and 1 month postoperatively

  • Changes in Sleep - PROMIS

    Baseline through 1 month postoperatively

  • +1 more secondary outcomes

Study Arms (3)

Group 1

EXPERIMENTAL

Meditation twice daily for at least two weeks prior to surgery and for four weeks after surgery

Behavioral: Meditation

Group 2

EXPERIMENTAL

Meditation twice daily for four weeks after surgery

Behavioral: Meditation

Group 3

NO INTERVENTION

Control group - will undergo surgery and subsequent hospital stay according to the current standard of care, which does not include meditation

Interventions

MeditationBEHAVIORAL

Isha Kriya (IK) meditation approximately 12 minutes, twice a day

Group 1Group 2

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • years of age or older
  • Undergoing any of the following types of cardiac surgery: CABG with or without valve surgery (aortic and/or mitral); isolated valve surgery; isolated aortic surgery
  • Surgery scheduled for at least 14 days after enrollment

You may not qualify if:

  • Urgent and/or emergent surgery
  • Non-English speaking
  • Cognitive impairment as defined by total MoCA score \< 10
  • Baseline DASS-21 depression score \>10
  • Pre-existing history of psychiatric illness as documented in the medical record or divulged in history taking in pre-enrollment patient interview, such as anxiety, depression, or bipolar disorder
  • History of cerebrovascular accident or recent history (\< 3 months) of seizures
  • History of dementia, Parkinson's disease, Alzheimer's disease, or other forms of cognitive decline
  • Current use of cognition enhancing drugs
  • Current management for chronic pain
  • Currently enrolled in another interventional study that could impact the primary outcome, as determined by the PI
  • Educational attainment below high school level or equivalent
  • Significant visual impairment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

Related Publications (1)

  • Packiasabapathy S, Susheela AT, Mueller A, Patxot M, Gasangwa DV, O'Gara B, Shaefi S, Marcantonio ER, Yeh GY, Subramaniam B. Guided meditation as an adjunct to enhance postoperative recovery after cardiac surgery: study protocol for a prospective randomized controlled feasibility trial. Trials. 2019 Jan 11;20(1):39. doi: 10.1186/s13063-018-3103-8.

MeSH Terms

Conditions

Cognitive Dysfunction

Interventions

Meditation

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental Disorders

Intervention Hierarchy (Ancestors)

Mind-Body TherapiesComplementary TherapiesTherapeuticsSpiritual TherapiesRelaxation TherapyBehavior TherapyPsychotherapyBehavioral Disciplines and Activities

Study Officials

  • Balachundhar Subramaniam, MD, MPH

    Beth Israel Deaconess Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 20, 2017

First Posted

June 23, 2017

Study Start

November 28, 2017

Primary Completion

April 30, 2020

Study Completion

April 30, 2020

Last Updated

June 4, 2024

Record last verified: 2024-06

Locations