Stress Echocardiography in Patients Recovery From Mild COVID-19 Illness

NCT04498299 | Unknown DMC

• 1 other identifier: Cardiology-004
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

With the appearance of the new SARS-COV2 virus, additional challenges are being imposed on the medical community after the resolution of acute COVID-19 illness, resulting in specific pathophysiologic mechanisms that while acutely damage the lung parenchyma might chronically impact the cardiopulmonary system. This study aims to investigate changes after mild COVID-19 illness in echocardiographic indices at rest and stress.

Conditions

Echocardiography, Stress; COVID-19; Hypertension, Pulmonary

Keywords

Echocardiography, Stress; COVID-19; Pulmonary Hypertension

Outcome Measures

Primary Outcomes (27)

• • LA volume index

  Left atrium volume index

  3 minutes

• • LV telediastolic diameter

  Left ventricle telediastolic diameter

  3 minutes

• • LV telesystolic diameter

  Left ventricle telesystolic diameter

  3 minutes

• • LV posterior wall

  Left ventricle posterior wall

  3 minutes

• • RA area

  Right atrium area

  3 minutes

• • RV basal dimensión

  Right ventricle basal dimensión

  3 minutes

• • RV mid cavity dimension;

  Right ventricle cavity dimensión

  3 minutes

• • RV longitudinal dimension

  Right ventricle longitudinal dimension

  3 minutes

• • Distal, RV outflow tract dimension at the distal or pulmonic valve level

  Distal, right ventricle outflow tract dimension at the distal or pulmonic valve level

  3 minutes

• • Proximal RV outflow tract dimension at the proximal subvalvular level

  Proximal right ventricle outflow tract dimension at the proximal subvalvular level

  3 minutes

• • TAPSE

  • Tricuspid annular plane systolic excursion

  3 minutes

• • RV free Wall strain

  Right ventricle free Wall strain

  3 minutes

• • Inferior cava vein PW Doppler

  Inferior cava vein PW Doppler

  3 minutes

• • E wave mitral

  E wave mitral

  3 minutes

• • A wave mitral

  A wave mitral

  3 minutes

• • E wave /A wave mitral

  E wave /A wave mitral

  3 minutes

• • E-wave at mitral annulus

  E-wave at mitral annulus

  3 minutes

• • E-wave at mitral annulus / A-wave at the mitral annulus

  E-wave at mitral annulus / A-wave at the mitral annulus

  3 minutes

• • E wave/ E-wave at the mitral annulus

  E wave/ E-wave at the mitral annulus

  3 minutes

• • E tricuspid (E)

  E tricuspid (E)

  3 minutes

• • A tricuspid (A)

  A triuspid (A)

  3 minutes

• • E/A

  E/A

  3 minutes

• • Systolic pulmonary artery pressure

  Systolic pulmonary artery pressure

  3 minutes

• • E-wave at the tricuspid annulus

  E-wave at the tricuspid annulus

  3 minutes

• • Mean pulmonary artery pressure

  Mean pulmonary artery pressure

  3 minutes

• • Stroke volume

  Stroke volume

  3 minutes

• • Cardiac output

  Cardiac output

  3 minutes

Interventions

echocardiogram 2D DIAGNOSTIC_TEST

The patient is accelerating against a workload that gradually increases at a constant rate during the exercise, images will be obtained by echocardiography. The patient begins with 25 Watts with increments of 25 Watts every 3 minutes, continuing the exercise until significant electrocardiographic changes occur or the patient starts with symptoms.

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients after the resolution of acute COVID-19 illness

You may qualify if:

• Having suffered mild COVID-19 illness
• PCR test negative after COVID-19 illness
• Men or women
• Age ≥18 years and \< 45.
• No history of other cardiovascular or lung disease.
• No cardiovascular risk factors, that is, arterial systemic hypertension, smoking, diabetes, dyslipidemia
• No ongoing or previous cardio or vasoactive treatment
• Able to use the semi-supine exercise bicycle
• Able to give informed consent

You may not qualify if:

• Poor acoustic window.
• Tricuspid regurgitation more than mild
• Professional sports activity
• Pregnancy
• Obesity (body mass index \[BMI\], ≥30 kg/m2).
• Inability to provide consent

Sponsors & Collaborators

• Miguel Ayala León: lead

Study Sites (1)

Hospital Beneficencia Española de Puebla

Puebla City, 72090, Mexico

RECRUITING

MeSH Terms

Conditions

COVID-19; Hypertension, Pulmonary

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

miguel ayala-leon

CONTACT

5529625396; terapia_intensiva_miguel@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NETWORK
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: cardiovascular critical care unit director

Study Record Dates

• First Submitted: July 31, 2020
• First Posted: August 4, 2020
• Study Start: September 1, 2020
• Primary Completion: October 1, 2020
• Study Completion: November 30, 2020
• Last Updated: August 4, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will not share

Locations

ME (1)