Singapore COVID-19 Chemosensory Tracking (SCCT) Study

NCT04492904 | Completed

• 1 other identifier: 2020/00810
• Study Type: observational
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to longitudinally track the onset, severity and recovery of changes in chemosensory acuity (smell and/or taste loss) among those suspected of COVID-19 infection. Using standardised questionnaire and testing approaches, the investigators aim to objectively characterise and measure temporal changes in taste and smell to confirm the prevalence of these symptoms as an early marker of infection. Information on symptoms experience, changes in appetite and food-related quality of life will be also be assessed via questionnaire. The results of the study will help individuals who experience a loss of smell and/or taste to self-isolate and/or self-refer to a medical professional, if an association between smell and/or taste and COVID-19 infection is found.

Conditions

Covid19

Keywords

Olfactory dysfunction; Gustatory dysfunction; Anosmia; Ageusia; SARS-CoV-2; COVID-19

Outcome Measures

Primary Outcomes (1)

• Taste and smell acuity

  Taste and smell functions of all participants will be assessed as part of the Home-use Test using taste test items (i.e. sweet: sugar, salty: salt, sour: lime powder and bitter: coffee powder) and odour pens respectively. Participants will identify the taste/smell and rate the perceived intensity on a Visual Analogue Scale (VAS) from 'not strong at all' (0) to 'extremely strong taste/smell' (100). A higher score will indicate greater intensity of taste/smell perceived.

  28 days

Secondary Outcomes (1)

• Experienced symptoms, changes in appetite and food-related quality of life

  28 days

Study Arms (2)

COVID-19 Positive (Case)

Participants who were present for COVID-19 screening and their test results will later indicate positive of infection. Participants will complete a one-time assessment of the various online questionnaires (Singapore Smell and Test Questionnaire, Sino-nasal Outcome Test-22, and Global Consortium for Chemosensory Research Questionnaire - Optional) in the hospital/clinic. Taste and smell acuity, as well as experienced symptoms, changes in appetite and food-related quality of life will be assessed using the Home-use Tests and Follow-up questionnaire over a period of 28 days.

Other: Home-use Test and Follow-up Questionnaire

COVID-19 Negative/Other respiratory diseases (Control)

Participants who were present for COVID-19 screening and their test results will later indicate negative of infection. Participants will complete a one-time assessment of the various online questionnaires (Singapore Smell and Test Questionnaire, Sino-nasal Outcome Test-22, and Global Consortium for Chemosensory Research Questionnaire - Optional) in the hospital/clinic. Taste and smell acuity, as well as experienced symptoms, changes in appetite and food-related quality of life will be assessed using the Home-use Tests and Follow-up questionnaire over a period of 28 days

Other: Home-use Test and Follow-up Questionnaire

Interventions

Home-use Test and Follow-up Questionnaire OTHER

Prospective tracking of changes in taste and smell acuity, and related changes in appetite, enjoyment of food and food-related quality of life will be assessed using the Home-use Tests and Follow-up questionnaire over a period of 28 days.

COVID-19 Negative/Other respiratory diseases (Control); COVID-19 Positive (Case)

Eligibility Criteria

• Age: 21 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients present for COVID 19 screening

You may qualify if:

• Age 21 years and above
• Residing in Singapore for the next 28 days.
• Possess a mobile device with 4G network and knows how to use mobile apps (i.e. QR scanner)

You may not qualify if:

• Unable to provide informed consent
• Allergic/ intolerant to test items (i.e. fragrances, sugar, salt, coffee or lime powder)
• Not agreeable with the study team accessing your medical records
• For women: Pregnant

Sponsors & Collaborators

• Singapore Institute of Food and Biotechnology Innovation: lead
• National University Hospital, Singapore: collaborator

Study Sites (1)

Clinical Nutrition Research Centre, Singapore

Singapore, 117599, Singapore

Location

Related Publications (1)

• Sheen F, Tan V, Haldar S, Sengupta S, Allen D, Somani J, Chen HY, Tambyah P, Forde CG. Evaluating the Onset, Severity, and Recovery of Changes to Smell and Taste Associated With COVID-19 Infection in a Singaporean Population (the COVOSMIA-19 Trial): Protocol for a Prospective Case-Control Study. JMIR Res Protoc. 2020 Dec 31;9(12):e24797. doi: 10.2196/24797.

  PMID: 33351775 DERIVED

MeSH Terms

Conditions

COVID-19; Anosmia; Ageusia

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Olfaction Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Taste Disorders

Study Officials

• Ciaran Forde, Phd

  Singapore Institute of Food and Biotechnology Innovation

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: July 27, 2020
• First Posted: July 30, 2020
• Study Start: July 17, 2020
• Primary Completion: June 15, 2021
• Study Completion: June 15, 2021
• Last Updated: December 14, 2021

Record last verified: 2021-12

Locations

SG (1)