NCT04489225

Brief Summary

Medtronic is sponsoring the HFRS PAS to evaluate the HFRS feature (TriageHF) when used in routine clinical practice following commercial release. The HFRS PAS is conducted within Medtronic's Product Surveillance Registry (PSR) platform.

Trial Health

82
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
2,200

participants targeted

Target at P75+ for all trials

Timeline
20mo left

Started Aug 2020

Longer than P75 for all trials

Geographic Reach
9 countries

92 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress78%
Aug 2020Jan 2028

First Submitted

Initial submission to the registry

July 23, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

July 28, 2020

Completed
4 days until next milestone

Study Start

First participant enrolled

August 1, 2020

Completed
4.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 6, 2024

Completed
3.2 years until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2028

Expected
Last Updated

October 20, 2025

Status Verified

October 1, 2025

Enrollment Period

4.4 years

First QC Date

July 23, 2020

Last Update Submit

October 16, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • positive predictive value (PPV) of HFRS High Risk Status associated with worsening heart failure

    To estimate the positive predictive value (PPV) of HFRS High Risk Status associated with worsening heart failure

    Up to 5 years

Secondary Outcomes (1)

  • Number of HF hospitalization or HF related deaths

    Up to 5 years

Study Arms (1)

Observational

This single arm observational study includes all patients implanted with a Medtronic Cobalt™ XT ICD or CRT-D MRI SureScan™ (with Attain StabilityQuad™ MRI SureScan™ Model 4798 Lead (ASQ)), who are enrolled in the Medtronic CareLink (CL) Network and Product Surveillance Registry (PSR). Patients will be followed per the standard of care practices of their care provider. All patients must provide a signed informed consent.

Other: Observational

Interventions

Observational only without any intervention

Observational

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The study population includes all patients implanted with a Medtronic Cobalt™ XT ICD or CRT-D MRI SureScan™ (with Attain StabilityQuad™ MRI SureScan™ Model 4798 Lead (ASQ)), who are enrolled in the Medtronic CareLink (CL) Network and Product Surveillance Registry (PSR).

You may qualify if:

  • Patient or legally authorized representative provides written authorization and/or consent per institution and geographical requirements
  • Patient has or is intended to receive or be treated with an eligible ICD or CRT device or Patients may be enrolled pre-implant and up to 30 days post-implant following confirmation of patient eligibility.
  • Patient is enrolled in the Medtronic CareLink® Network for remote monitoring.

You may not qualify if:

  • Patient who is, or is expected to be inaccessible for follow-up
  • Patient is currently enrolled in or plans to enroll in any concurrent drug and/or device study that may confound results.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (92)

Southwest EP

Chandler, Arizona, 85226, United States

Location

Saint Vincent Heart Clinic Arkansas

Little Rock, Arkansas, 72205-6202, United States

Location

Chula Vista Cardiac Center

Chula Vista, California, 91910, United States

Location

Cardiovascular Consultants Medical Group

Van Nuys, California, 91405, United States

Location

Cardiology Associates Medical Group

Ventura, California, 93003-2840, United States

Location

Colorado Springs Cardiology

Colorado Springs, Colorado, 80907, United States

Location

Denver Heart

Denver, Colorado, 80220-3918, United States

Location

Colorado Heart and Vascular, PC

Lakewood, Colorado, 80228, United States

Location

Hartford Hospital

Hartford, Connecticut, 06102-8000, United States

Location

Yale New Haven Hospital

New Have, Connecticut, 06510, United States

Location

Heart Rhythm Solutions

Hollywood, Florida, 33021, United States

Location

Baptist Health

Jacksonville, Florida, 32207, United States

Location

Cardiovascular Institute of Northwest Florida

Panama City, Florida, 32405, United States

Location

Heart & Vascular Institute of Florida

Safety Harbor, Florida, 34695-6604, United States

Location

Heart Rhythm Consultants P.A. (Sarasota Memorial Research)

Sarasota, Florida, 34233, United States

Location

Deaconess Specialty Physicians

Evansville, Indiana, 47710-1658, United States

Location

Iowa Heart

Des Moines, Iowa, 50266, United States

Location

The University of Kansas Medical Center

Kansas City, Kansas, 66160-8500, United States

Location

Norton Heart and Vascular Institute

Louisville, Kentucky, 40205-3373, United States

Location

TidalHealth Peninsula Regional, Inc.

Salisbury, Maryland, 21804, United States

Location

Associates in Cardiology PA

Silver Spring, Maryland, 20910-1265, United States

Location

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Sparrow Clinical Research Institute

Lansing, Michigan, 48912, United States

Location

Michigan Heart

Ypsilanti, Michigan, 48197-8633, United States

Location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Location

Missouri Cardiovascular Specialists

Columbia, Missouri, 65201-8023, United States

Location

University Hospital of Missouri

Columbia, Missouri, 65212, United States

Location

Saint Lukes Health System

Kansas City, Missouri, 64111-5934, United States

Location

Washington University School of Medicine

St Louis, Missouri, 63110-1010, United States

Location

Nebraska Medicine

Omaha, Nebraska, 68105, United States

Location

Monmouth Cardiology Associates

Eatontown, New Jersey, 07724, United States

Location

Presbyterian Heart Group

Albuquerque, New Mexico, 87106-4921, United States

Location

South Shore University Hospital

Bay Shore, New York, 11706, United States

Location

Huntington Hospital

Huntington, New York, 11743, United States

Location

North Shore University Hospital

Manhasset, New York, 11030, United States

Location

Northern Westchester Hospital

Mount Kisco, New York, 10549, United States

Location

Long Island Jewish Medical Center

New Hyde Park, New York, 11040, United States

Location

New York-Presbyterian Hospital/Weill-Cornell Medical Center

New York, New York, 10021, United States

Location

NewYork-Presbyterian/Columbia University Irving Medical Center

New York, New York, 10032, United States

Location

Lenox Hill Hospital

New York, New York, 10075, United States

Location

Hudson Valley Heart Center

Poughkeepsie, New York, 12601-3923, United States

Location

Staten Island University Hospital

Staten Island, New York, 10305, United States

Location

WakeMed Health & Hospitals

Raleigh, North Carolina, 27610, United States

Location

Summa Center for Clinical Trials-Northeast Ohio Cardiovascular Specialists

Akron, Ohio, 44304-1473, United States

Location

The Christ Hospital Health Network

Cincinnati, Ohio, 45219, United States

Location

St Lukes University Health Network

Bethlehem, Pennsylvania, 18015, United States

Location

Saint Thomas Research Institute

Nashville, Tennessee, 37205-2018, United States

Location

Texas Cardiac Arrhythmia Research Foundation

Austin, Texas, 78705-1852, United States

Location

Consultants in Cardiology

Fort Worth, Texas, 76104-2821, United States

Location

Heart Center of North Texas

Fort Worth, Texas, 76104, United States

Location

Aurora Cardiovascular Services

Milwaukee, Wisconsin, 53215, United States

Location

Clinique Rhone Durance

Avignon, France, France

Location

Ch de La Region D'Annecy

Metz-Tessy, France, France

Location

Nouvelles Cliniques Nantaises

Nantes, France, France

Location

Chu Nord Saint-Étienne

Saint-Priest-en-Jarez, France, France

Location

CHU de Brest

Brest, France

Location

CHU de Caen - Hôpital Côte de Nacre - Centre Esquirol

Caen, France

Location

Générale de Santé - Hôpital Privé Saint Martin

Caen, France

Location

Centre Hospitalier Universitaire de Clermont-Ferrand - Gabriel-Montpied

Clermont-Ferrand, France

Location

CHU de Dijon - Hospital Le Bocage

Dijon, France

Location

CHRU La Rochelle

La Rochelle, France

Location

Capio - Clinique du Tonkin

Villeurbanne, France

Location

Hygeia Hospital

Athens, Greece

Location

Athens Medical Center

Marousi, Greece

Location

Policlinico Sant' Orsola - Malpighi

Bologna, Italy

Location

Azienda Sanitaria Provinciale di Cosenza "Ospedale di Castrovillari"

Cosenza, Italy

Location

Ospedale "Vito Fazzi" Lecce

Lecce, Italy

Location

Azienda Ospedaliera Ospedale Niguarda Ca Granda

Milan, Italy

Location

Presidio Ospedaliero Centrale - SS. Annunziata

Taranto, Italy

Location

Azienda ospedaleria Santa Maria della Misericordia di Udine

Udine, Italy

Location

Hospital da Senhora da Oliveira - Guimarães

Guimarães, Portugal

Location

Hospital de Santa Maria-Centro Hospitalar Lisboa Norte, EPE

Lisbon, Portugal

Location

Centro Hospitalar Universitário de São João

Porto, Portugal

Location

Hospital Distrital de Santarém

Santarém, Portugal

Location

Národný ústav srdcových a cievnych chorôb, a.s. (NÚSCH, a.s.)

Bratislava, Slovakia

Location

Hospital Universitario da Coruña

A Coruña, Spain

Location

Hospital Universitario Clínico San Cecilio

Granada, Spain

Location

Hospital Universitario Virgen de las Nieves

Granada, Spain

Location

Hospital Universitario 12 de Octubre

Madrid, Spain

Location

Complejo Universitario de Salamanca

Salamanca, Spain

Location

Hospital Universitario Nuestra Señora de Candelaria

Santa Cruz de Tenerife, Spain

Location

Complejo Hospitalario Universitario de Santiago de Compostela

Santiago, Spain

Location

Hospital Clínico Universitario de Valladolid

Valladolid, Spain

Location

Hôpitaux Universitaires de Genève

Geneva, Switzerland

Location

Cardiopark Zurich

Zurich, Switzerland

Location

University Hospitals of Birmingham NHS Foundation Trust - Queen Elizabeth Hospital

Birmingham, United Kingdom

Location

Blackpool, Fylde and Wyre Hospitals NHS Foundation Trust - Blackpool Victoria Hospital

Blackpool, United Kingdom

Location

Liverpool Heart and Chest Hospital NHS Foundation Trust

Liverpool, United Kingdom

Location

Imperial College Healthcare NHS Trust - Hammersmith Hospital

London, United Kingdom

Location

Central Manchester University Hospitals NHS - Manchester Royal Infirmary

Manchester, United Kingdom

Location

The James Cook University Hospital - South Tees Hospitals NHS

Middlesbrough, United Kingdom

Location

Sheffield Vascular Institute, Sheffield Teaching Hospitals NHS - Northern General

Sheffield, United Kingdom

Location

MeSH Terms

Conditions

Heart Failure

Interventions

Watchful Waiting

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Intervention Hierarchy (Ancestors)

Outcome Assessment, Health CareOutcome and Process Assessment, Health CareQuality of Health CareHealth Services Administration

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 23, 2020

First Posted

July 28, 2020

Study Start

August 1, 2020

Primary Completion

December 6, 2024

Study Completion (Estimated)

January 31, 2028

Last Updated

October 20, 2025

Record last verified: 2025-10

Locations