NCT04483310

Brief Summary

The aim of the study is to evaluate, with a small-scale pilot study, the efficacy of Meditation Relaxation therapy for Sleep Paralyses in patients with narcolepsy. The study involves two arms, with intervention with Meditation Relaxation therapy or sham over a period of three months.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Dec 2018

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

December 1, 2018

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

July 3, 2020

Completed
20 days until next milestone

First Posted

Study publicly available on registry

July 23, 2020

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

July 23, 2020

Status Verified

July 1, 2020

Enrollment Period

4.1 years

First QC Date

July 3, 2020

Last Update Submit

July 22, 2020

Conditions

Keywords

Behavioral TreatmentSleep ParalysisNarcolepsy Type 1

Outcome Measures

Primary Outcomes (1)

  • Sleep Paralysis Experiences and Phenomenology Questionnaire (SP-EPQ)

    The questionnaire addresses the distress associated with SP.

    Three months.

Secondary Outcomes (1)

  • Daily journal

    Three months.

Study Arms (2)

MR therapy

EXPERIMENTAL

MR therapy is a psychological treatment for SP, comprised of the following steps applied directly during the attack: Step I: Reappraisal of the meaning of the attack; Step II: psychological and emotional distancing; Step III: inward focused-attention meditation; Step IV: Muscle relaxation.

Behavioral: MR therapy.

Control intervention

ACTIVE COMPARATOR

The control intervention was identical, except participants engaged in deep breathing; entailing slow deep breaths, while repeatedly counting from 1-10. This is an active control (breathing-distraction exercise) rather than a placebo.

Behavioral: breathing-distraction exercise

Interventions

MR therapy.BEHAVIORAL

MR therapy is based on 4 steps applied directly during the attack: Step I: Reappraisal of the meaning of the attack; Step II: psychological and emotional distancing; Step III: inward focused-attention meditation; Step IV: Muscle relaxation.

MR therapy

The control intervention is based on a breathing exercise, the patients should entail slow deep breaths, while repeatedly counting from 1-10

Control intervention

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Narcolepsy (type 1 and 2) based on polysomnography, Multiple Sleep Latency Test \[MLST\] and CSF hypocretin level testing).
  • Patients had to have experienced SP at least four times in the last month.

You may not qualify if:

  • Psychiatric comorbidity.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Azienda USL di Bologna

Bologna, Italy

RECRUITING

MeSH Terms

Conditions

Sleep Paralysis

Condition Hierarchy (Ancestors)

REM Sleep ParasomniasParasomniasSleep Wake DisordersNervous System DiseasesMental Disorders

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 3, 2020

First Posted

July 23, 2020

Study Start

December 1, 2018

Primary Completion

December 31, 2022

Study Completion

December 31, 2022

Last Updated

July 23, 2020

Record last verified: 2020-07

Locations