COVID-19 in Patients With Anosmia in Egypt

NCT04473157 | Completed

• 1 other identifier: FMASU P45a/2020
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to test the frequency of severe acute respiratory syndrome new corona virus SARS-CoV-2 or other respiratory viruses in patients presenting with anosmia or dysgeusia to Ain Shams University Hospitals, Cairo, Egypt.

Conditions

Anosmia; Covid19; Dysgeusia

Keywords

Corona virus; SARS-CoV-2; Olfactory Disturbance; Taste Disturbance

Outcome Measures

Primary Outcomes (2)

• Recovery from Anosmia

  subjective questionnaire about smell and taste

  3 weeks

• Seroconversion

  developing IgM/ IgG antibodies by rapid test

  3 weeks

Secondary Outcomes (1)

• COVID 19

  3 weeks

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Fifty Patients presenting to Triage and/or ENT clinics in Ain Shams University Hospitals with the chief complaint of Anosmia/ dysgeusia in the period July- August 2020

You may qualify if:

• adult (\>18 years) patients presented with acute-onset anosmia.

You may not qualify if:

• patients with anosmia or gustatory dysfunctions before the epidemic; patients with previous history of chronic sinusitis or previous sinus surgery.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, Egypt

Location

Related Publications (4)

• Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020 Aug;10(8):944-950. doi: 10.1002/alr.22587. Epub 2020 Jun 18.

  PMID: 32301284 BACKGROUND

• Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C, Boscolo-Rizzo P. Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. JAMA. 2020 May 26;323(20):2089-2090. doi: 10.1001/jama.2020.6771.

  PMID: 32320008 BACKGROUND

• Menni C, Valdes AM, Freidin MB, Sudre CH, Nguyen LH, Drew DA, Ganesh S, Varsavsky T, Cardoso MJ, El-Sayed Moustafa JS, Visconti A, Hysi P, Bowyer RCE, Mangino M, Falchi M, Wolf J, Ourselin S, Chan AT, Steves CJ, Spector TD. Real-time tracking of self-reported symptoms to predict potential COVID-19. Nat Med. 2020 Jul;26(7):1037-1040. doi: 10.1038/s41591-020-0916-2. Epub 2020 May 11.

  PMID: 32393804 BACKGROUND

• Desforges M, Le Coupanec A, Brison E, Meessen-Pinard M, Talbot PJ. Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans. Adv Exp Med Biol. 2014;807:75-96. doi: 10.1007/978-81-322-1777-0_6.

  PMID: 24619619 BACKGROUND

Biospecimen

Retention: SAMPLES WITHOUT DNA

Nasopharyngeal and oropharyngeal Swabs

MeSH Terms

Conditions

Anosmia; COVID-19; Dysgeusia

Condition Hierarchy (Ancestors)

Olfaction Disorders; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Taste Disorders

Study Officials

• Ossama I Mansour, MD

  Ain Shams University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Otolaryngology

Study Record Dates

• First Submitted: July 15, 2020
• First Posted: July 16, 2020
• Study Start: July 1, 2020
• Primary Completion: November 30, 2020
• Study Completion: December 30, 2020
• Last Updated: January 15, 2021

Record last verified: 2021-01

Locations

EG (1)