NCT04464902

Brief Summary

To develop new prevention programs for non-contact ACL injuries that do not require additional training time and assistance from a sports medicine professional personnel. A knee extension constraint will be utilized to patients who have undertaken ACL reconstruction. And to determine the effects of knee extension constraint rehabilitation on lower extremity biomechanics after ACL reconstruction surgery.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jul 2016

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

July 28, 2016

Completed
3.9 years until next milestone

First Submitted

Initial submission to the registry

June 30, 2020

Completed
9 days until next milestone

First Posted

Study publicly available on registry

July 9, 2020

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2020

Completed
1 year until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2021

Completed
Last Updated

July 9, 2020

Status Verified

June 1, 2020

Enrollment Period

4.4 years

First QC Date

June 30, 2020

Last Update Submit

July 6, 2020

Conditions

Keywords

anterior cruciate ligamentinjury preventionknee extension constraint

Outcome Measures

Primary Outcomes (12)

  • walking speed

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 24 weeks after ACL reconstruction surgery.

  • walking speed

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 36 weeks after ACL reconstruction surgery.

  • walking speed

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 48 weeks after ACL reconstruction surgery.

  • ground reaction force

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 24 weeks after ACL reconstruction surgery.

  • ground reaction force

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 36 weeks after ACL reconstruction surgery.

  • ground reaction force

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 48 weeks after ACL reconstruction surgery.

  • knee flexion angle

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 24 weeks after ACL reconstruction surgery.

  • knee flexion angle

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 36 weeks after ACL reconstruction surgery.

  • knee flexion angle

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 48 weeks after ACL reconstruction surgery.

  • the moment of knee extension in the gait cycle

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 24 weeks after ACL reconstruction surgery.

  • the moment of knee extension in the gait cycle

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 36 weeks after ACL reconstruction surgery.

  • the moment of knee extension in the gait cycle

    Three-dimensional gait analysis system were used during walking, jogging, cutting and jumping.

    at 48 weeks after ACL reconstruction surgery.

Secondary Outcomes (3)

  • The International Knee Documentation Committee (IKDC) score

    at 24 weeks after ACL reconstruction surgery.

  • The International Knee Documentation Committee (IKDC) score

    at 36 weeks after ACL reconstruction surgery.

  • The International Knee Documentation Committee (IKDC) score

    at 48 weeks after ACL reconstruction surgery.

Study Arms (3)

knee extension constraint rehabilitation group

OTHER
Device: brace1

placebo group

OTHER
Device: brace2

control group

OTHER
Other: No Intervention

Interventions

brace1DEVICE

The brace1 can provide resistance when patients want to extend their knee.

knee extension constraint rehabilitation group
brace2DEVICE

The brace1 can't provide resistance when patients want to extend their knee.

placebo group

Control Group don't have any brace.

control group

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Patients who have isolated ACL injury and receive ACL reconstruction surgery at Sports Medicine Center, 3rd Hospital of Beijing University, Beijing, China.
  • years old
  • With isolated ACL injury (an ACL injury with no need for surgical repairs to other knee structures).
  • All participants have no known disorders or diseases other than ACL rupture.

You may not qualify if:

  • Female patients who are pregnant, or suspected pregnant, or in breastfeeding will be excluded from this study.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Peking University Third Hospital

Beijing, 100191, China

RECRUITING

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries

Condition Hierarchy (Ancestors)

Knee InjuriesLeg InjuriesWounds and Injuries

Study Officials

  • Hongshi Huang, Doctor

    Peking University Third Hospital

    STUDY CHAIR

Central Study Contacts

Yuanyuan Yu, Bachler

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
Patients and investigator all don't know which group they participated in.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 30, 2020

First Posted

July 9, 2020

Study Start

July 28, 2016

Primary Completion

December 30, 2020

Study Completion

December 31, 2021

Last Updated

July 9, 2020

Record last verified: 2020-06

Data Sharing

IPD Sharing
Will not share

Locations