6-Month Outcomes of PEMF to Nucleotide Sources Revealing Cell Sensory Experience in Pain Relief, Stress Relief and Anti Ageing Restoration

NCT04461470 | Unknown DMC

• 1 other identifier: 7012
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The hz Clinic registry is a programme made of five scheduled cohorts designed to include participants dealing with Immunity compromise, Pain, Ageing and Stress (general and pandemic anxieties) who are to be followed for 6 month to five years in their structured routine of pulsed electro resonance (PEMF) to determine their clinical outcome in the real world, contributing evidence for benchmarking fellow cohort participant variance. Here we report baseline characteristics, PEMF transfer events and outcomes in participants in the UK. This study serves as a calibration proforma for downstream real world evidence observations of PEMF in the field.

Conditions

Pain; Stress; Ageing Signs; Immunity Compromise

Outcome Measures

Primary Outcomes (4)

• Pain alleviation

  McGill Index Score 0 - 5

  Imminence - one day

• Stress alleviation

  McGill Index Score 0 - 5

  Imminence - one day

• Anti ageing

  McGill Index Score 0 - 5

  Imminence - one day

• Inflammation quenching

  McGill Index Score 0 - 5

  Imminence - one day

Study Arms (2)

London

pulsed electro resonance hz 4, hz 3, hz 2, hz 3.5 and residual hz 5

Genetic: epigenetic longitudinal waves

All United Kingdom

pulsed electro resonance hz 4, hz 3, hz 2, hz 3.5 and residual hz 5

Genetic: epigenetic longitudinal waves

Interventions

epigenetic longitudinal waves GENETIC

force - inducing energies using electromagnetic field(s)

Also known as: hz

All United Kingdom; London

Eligibility Criteria

• Age: 16 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Distinct community regions - United Kingdom, London.

You may qualify if:

• Adept to social media / technology uses and convenience of care / health benchmarking

You may not qualify if:

• History of cardiovascular issue

Sponsors & Collaborators

• hz Clinic: lead
• East London Electric Company: collaborator
• PropDesk: collaborator
• MedCity: collaborator
• UCL Partners: collaborator
• Imperial College London Partners: collaborator
• Health Innovation Network: collaborator

Study Sites (1)

hz Clinic

London, E20 3BS, United Kingdom

RECRUITING

Related Publications (14)

• Bagnato GL, Miceli G, Marino N, Sciortino D, Bagnato GF. Pulsed electromagnetic fields in knee osteoarthritis: a double blind, placebo-controlled, randomized clinical trial. Rheumatology (Oxford). 2016 Apr;55(4):755-62. doi: 10.1093/rheumatology/kev426. Epub 2015 Dec 24.

  PMID: 26705327 BACKGROUND

• Booth CM, Tannock IF. Randomised controlled trials and population-based observational research: partners in the evolution of medical evidence. Br J Cancer. 2014 Feb 4;110(3):551-5. doi: 10.1038/bjc.2013.725. Epub 2014 Jan 14. No abstract available.

  PMID: 24495873 BACKGROUND

• Ferroni L, Gardin C, Dolkart O, Salai M, Barak S, Piattelli A, Amir-Barak H, Zavan B. Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-alpha mediated inflammatory conditions: an in-vitro study. Sci Rep. 2018 Mar 23;8(1):5108. doi: 10.1038/s41598-018-23499-9.

  PMID: 29572540 BACKGROUND

• Funk RH. Coupling of pulsed electromagnetic fields (PEMF) therapy to molecular grounds of the cell. Am J Transl Res. 2018 May 15;10(5):1260-1272. eCollection 2018.

  PMID: 29887943 BACKGROUND

• Kolifarhood G, Aghaali M, Mozafar Saadati H, Taherpour N, Rahimi S, Izadi N, Hashemi Nazari SS. Epidemiological and Clinical Aspects of COVID-19; a Narrative Review. Arch Acad Emerg Med. 2020 Apr 1;8(1):e41. eCollection 2020.

  PMID: 32259130 BACKGROUND

• Mitchell CA, Long H, Donaldson M, Francese S, Clench MR. Lipid changes within the epidermis of living skin equivalents observed across a time-course by MALDI-MS imaging and profiling. Lipids Health Dis. 2015 Aug 5;14:84. doi: 10.1186/s12944-015-0089-z.

  PMID: 26243140 BACKGROUND

• Mitchell CA, Donaldson M, Francese S, Clench MR. MALDI MSI analysis of lipid changes in living skin equivalents in response to emollient creams containing palmitoylethanolamide. Methods. 2016 Jul 15;104:93-100. doi: 10.1016/j.ymeth.2016.02.001. Epub 2016 Feb 2.

  PMID: 26845462 BACKGROUND

• Mun EJ, Babiker HM, Weinberg U, Kirson ED, Von Hoff DD. Tumor-Treating Fields: A Fourth Modality in Cancer Treatment. Clin Cancer Res. 2018 Jan 15;24(2):266-275. doi: 10.1158/1078-0432.CCR-17-1117. Epub 2017 Aug 1.

  PMID: 28765323 BACKGROUND

• Osler M, Rozing MP, Christensen GT, Andersen PK, Jorgensen MB. Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study. Lancet Psychiatry. 2018 Apr;5(4):348-356. doi: 10.1016/S2215-0366(18)30056-7. Epub 2018 Mar 6.

  PMID: 29523431 BACKGROUND

• Peterchev AV, Wagner TA, Miranda PC, Nitsche MA, Paulus W, Lisanby SH, Pascual-Leone A, Bikson M. Fundamentals of transcranial electric and magnetic stimulation dose: definition, selection, and reporting practices. Brain Stimul. 2012 Oct;5(4):435-53. doi: 10.1016/j.brs.2011.10.001. Epub 2011 Nov 1.

  PMID: 22305345 BACKGROUND

• Phelps DL, Balog J, Gildea LF, Bodai Z, Savage A, El-Bahrawy MA, Speller AV, Rosini F, Kudo H, McKenzie JS, Brown R, Takats Z, Ghaem-Maghami S. The surgical intelligent knife distinguishes normal, borderline and malignant gynaecological tissues using rapid evaporative ionisation mass spectrometry (REIMS). Br J Cancer. 2018 May;118(10):1349-1358. doi: 10.1038/s41416-018-0048-3. Epub 2018 Apr 19.

  PMID: 29670294 BACKGROUND

• Reid B, Zhao M. The Electrical Response to Injury: Molecular Mechanisms and Wound Healing. Adv Wound Care (New Rochelle). 2014 Feb 1;3(2):184-201. doi: 10.1089/wound.2013.0442.

  PMID: 24761358 BACKGROUND

• Sawhney JP, Kothiwale VA, Bisne V, Durgaprasad R, Jadhav P, Chopda M, Vanajakshamma V, Meena R, Vijayaraghavan G, Chawla K, Allu J, Pieper KS, John Camm A, Kakkar AK; GARFIELD-AF Investigators. Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry. Indian Heart J. 2018 Nov-Dec;70(6):828-835. doi: 10.1016/j.ihj.2018.09.001. Epub 2018 Sep 12.

  PMID: 30580852 BACKGROUND

• Strauch B, Herman C, Dabb R, Ignarro LJ, Pilla AA. Evidence-based use of pulsed electromagnetic field therapy in clinical plastic surgery. Aesthet Surg J. 2009 Mar-Apr;29(2):135-43. doi: 10.1016/j.asj.2009.02.001.

  PMID: 19371845 BACKGROUND

Related Links

• Related Info

MeSH Terms

Conditions

Pain

Condition Hierarchy (Ancestors)

Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Christopher L Davies

  East London Electric Company

  STUDY CHAIR

Central Study Contacts

Christopher A Mitchell, PhD

CONTACT

+447497611090; info@hzclinic.co.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Week
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2020
• First Posted: July 8, 2020
• Study Start: August 29, 2019
• Primary Completion: February 12, 2020
• Study Completion: September 12, 2024
• Last Updated: July 16, 2020

Record last verified: 2020-02

Locations

GB (1)