The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field
TITAN
1 other identifier
interventional
150
1 country
2
Brief Summary
The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Aug 2020
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
June 30, 2020
CompletedFirst Posted
Study publicly available on registry
July 7, 2020
CompletedStudy Start
First participant enrolled
August 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 31, 2027
ExpectedStudy Completion
Last participant's last visit for all outcomes
July 31, 2027
April 30, 2026
April 1, 2026
7 years
June 30, 2020
April 29, 2026
Conditions
Outcome Measures
Primary Outcomes (2)
Cardiac Magnetic Resonance Imaging
Cardiac Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves
At baseline
Fast Field Cycling Magnetic Resonance Imaging
Fast Field Cycling Magnetic Resonance Imaging - Cardiac Scan to assess cardiac function and T1 dispersion curves
At baseline
Study Arms (2)
Myocardial Infarction Group
EXPERIMENTALPatients diagnosed with a myocardial infarction
Healthy Volunteers
EXPERIMENTALHealthy Volunteers
Interventions
Cardiac Magnetic Resonance Imaging - Cardiac Scan
Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan
Eligibility Criteria
You may qualify if:
- Participant who is willing and able to give informed consent for participation in the study
- Healthy volunteers willing to give informed consent for participation in the study
- Patients diagnosed with a previous myocardial infarction
You may not qualify if:
- Unwillingness to participate
- Claustrophobia
- Contraindication to MRI scanning such as implantable cardiac devices
- Participants who have had a previous myocardial infarction in the past of which they may not be aware and this is discovered whilst being scanned on the 3T MRI scanner, or who may have any other cardiology condition that they were previously unaware will not be included in the healthy control group, even if they present themselves to us as "healthy" at the time of the study visit
- Pregnancy
- Body habitus that may preclude comfortable positioning of the volunteer in either of the MRI scanners (\>50cm in diameter)
- Participants with abnormal kidney function that will preclude them from receiving a contrast agent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Cardiovascular Research Facility
Aberdeen, Aberdeenshire, AB25 2ZD, United Kingdom
University of Aberdeen and NHS Grampian
Aberdeen, Aberdeenshire, AB25 2ZD, United Kingdom
Related Publications (6)
Broche LM, Ross PJ, Pine KJ, Lurie DJ. Rapid multi-field T(1) estimation algorithm for Fast Field-Cycling MRI. J Magn Reson. 2014 Jan;238:44-51. doi: 10.1016/j.jmr.2013.10.010. Epub 2013 Oct 31.
PMID: 24309067BACKGROUNDKimmich R, Nusser W, Winter F. In vivo NMR field-cycling relaxation spectroscopy reveals 14N1H relaxation sinks in the backbones of proteins. Phys Med Biol. 1984 May;29(5):593-6. doi: 10.1088/0031-9155/29/5/011. No abstract available.
PMID: 6739544BACKGROUNDBroche LM, Ismail SR, Booth NA, Lurie DJ. Measurement of fibrin concentration by fast field-cycling NMR. Magn Reson Med. 2012 May;67(5):1453-7. doi: 10.1002/mrm.23117. Epub 2011 Oct 24.
PMID: 22025420BACKGROUNDBroche LM, Ashcroft GP, Lurie DJ. Detection of osteoarthritis in knee and hip joints by fast field-cycling NMR. Magn Reson Med. 2012 Aug;68(2):358-62. doi: 10.1002/mrm.23266. Epub 2011 Dec 12.
PMID: 22161576BACKGROUNDScally C, Abbas H, Ahearn T, Srinivasan J, Mezincescu A, Rudd A, Spath N, Yucel-Finn A, Yuecel R, Oldroyd K, Dospinescu C, Horgan G, Broadhurst P, Henning A, Newby DE, Semple S, Wilson HM, Dawson DK. Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy. Circulation. 2019 Mar 26;139(13):1581-1592. doi: 10.1161/CIRCULATIONAHA.118.037975.
PMID: 30586731BACKGROUNDAntonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017 Jul 12;9(398):eaal2658. doi: 10.1126/scitranslmed.aal2658.
PMID: 28701474BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Dana Dawson, DPhil
University of Aberdeen
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 30, 2020
First Posted
July 7, 2020
Study Start
August 1, 2020
Primary Completion (Estimated)
July 31, 2027
Study Completion (Estimated)
July 31, 2027
Last Updated
April 30, 2026
Record last verified: 2026-04
Data Sharing
- IPD Sharing
- Will not share