SURgical Outcomes in COvid Patients - the SUROCO Multicenter Cohort Study (COVID-19)

NCT04458337 | Completed

• 1 other identifier: 19.386
• Study Type: observational
• Target: 318
• Locations: 1 country
• Sites: 1

Brief Summary

Overall mortality of COVID-19 is variable and has been reported to be between less than 1% and 7%. Many authors around the world also reported data on hospitalization rate, need for intensive care unit (ICU) care and need for mechanical ventilation in SARS-CoV-2 infected patients. To provide anesthetic and surgical care to SARS-CoV-2 infected patients, many health workers have to organize surgical platforms, personal protections and in-hospital trajectories to prevent dissemination and cross-contamination. However, no data has been published on the surgical need of these patients, their postoperative outcomes and the impact they may have on the operating room. Postoperative outcomes in SARS-CoV-2 infected patients seem to be variable. Expected benefits from a surgical procedure may be different in this population if their postoperative mortality is higher than expected. The association between preoperative characteristics and postoperative outcomes in this population has to be better defined. There is a need to better quantify these and better inform use of surgical resources during a pandemic. To address this knowledge gap, the investigators propose to conduct a multicenter observational cohort study in SARS-CoV-2 infected patients undergoing a surgical procedure, as well as in those who have recovered from COVID-19.

Conditions

Covid-19; SARS-CoV2; Surgery; Surgical Procedure; Complications, Late Effect of Complications; Postoperative Complications

Outcome Measures

Primary Outcomes (1)

• Hospital survival

  Survival was calculated from the date of participant randomization to the date of participant death due to any cause. If the participant was discharged from the hospital and not seen afterwards, the date of hospital discharge was entered as the last day seen alive.

  30 days post-operation

Secondary Outcomes (12)

• Occurrence of postoperative respiratory complications

  30 days post-operation

• Occurrence of postoperative non-pulmonary infectious complications

  30 days post-operation

• Occurrence of acute kidney injury (AKI)

  30 days post-operation

• Occurrence of postoperative thromboembolic complications

  30 days post-operation

• The need for a new postoperative ICU admission

  30 days post-operation

Study Arms (1)

SARS-CoV-2 patients undergoing a surgical procedure

The investigators propose to conduct a prospective observational cohort study on all patients suspected or confirmed being infected to SARS-CoV-2, or recovered from SARS-CoV-2, undergoing a surgery.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients (children and adults) confirmed being infected to SARS-CoV-2 will be included, as well as patients who have recovered, undergoing a surgical procedure in designated Canadian Centers. The investigators will include all patients up to 30th day of April 2021.

You may qualify if:

• all patients undergoing a surgery with either a SARS-CoV-2 clinical suspicion based on reported symptoms during the pandemic (fever, myalgia, fatigue, cough, dyspnea, respiratory failure, diarrhea, vomiting, abdominal pain) or without any suggestive symptoms AND a SARS-CoV-2 confirmed infection with RT-PCR before surgery or within 72 hours after surgery. Patients who have recovered from SARS-CoV-2 infection will also be included. All patients up to 30th day of April 2021 will be included.

You may not qualify if:

• none

Sponsors & Collaborators

• Centre hospitalier de l'Université de Montréal (CHUM): lead
• Maisonneuve-Rosemont Hospital: collaborator
• Centre de recherche du Centre hospitalier universitaire de Sherbrooke: collaborator
• Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal: collaborator
• St. Justine's Hospital: collaborator
• Institut de Cardiologie de Montréal: collaborator
• McGill University Health Centre/Research Institute of the McGill University Health Centre: collaborator
• CHU de Quebec-Universite Laval: collaborator
• Institut universitaire de cardiologie et de pneumologie de Québec, University Laval: collaborator

Study Sites (1)

Centre Hospitalier de l'Université de Montréal (CHUM)

Montreal, Quebec, H2X 3E4, Canada

Location

Related Publications (2)

• Amzallag E, Panchadsaram T, Girard M, Lecluyse V, Couture E, D'Aragon F, Kandelman S, Turgeon AF, Jodoin C, Beaulieu P, Richebe P, Carrier FM. Pulmonary complications and mortality among COVID-19 patients undergoing a surgery: a multicentre cohort study. BMJ Open. 2024 Nov 21;14(11):e090158. doi: 10.1136/bmjopen-2024-090158.

  PMID: 39578040 DERIVED

• Carrier FM, Amzallag E, Lecluyse V, Cote G, Couture EJ, D'Aragon F, Kandelman S, Turgeon AF, Deschamps A, Nitulescu R, Djade CD, Girard M, Beaulieu P, Richebe P. Postoperative outcomes in surgical COVID-19 patients: a multicenter cohort study. BMC Anesthesiol. 2021 Jan 12;21(1):15. doi: 10.1186/s12871-021-01233-9.

  PMID: 33435887 DERIVED

MeSH Terms

Conditions

COVID-19; Postoperative Complications

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• François-Martin Carrier, MD, FRCPC

  Centre hospitalier de l'Université de Montréal (CHUM)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 26, 2020
• First Posted: July 7, 2020
• Study Start: March 13, 2020
• Primary Completion: March 13, 2022
• Study Completion: April 13, 2022
• Last Updated: July 12, 2022

Record last verified: 2021-09

Locations

CA (1)