Pulmonary and Extrapulmonary Impairments in Patients With Lung Cancer Awaiting Surgery

NCT04450719 | Completed

• 1 other identifier: Gazi University 20
• Study Type: observational
• Target: 47
• Locations: 1 country
• Sites: 1

Brief Summary

To detect comparatively the extent to which physical impairments are observed in patients with lung cancer awaiting lung surgery, comparing exercise capacity, pulmonary functions, muscle strength, physical activity, dyspnea, fatigue and quality of life between the patients with lung cancer and healthy individuals was aimed in current study.

Conditions

Lung Cancer

Keywords

lung cancer; walk test; pulmonary functions; muscle strength; physical activity; quality of life

Outcome Measures

Primary Outcomes (1)

• 6-minute walk test (6-MWT)

  Exercise capacity was evaluated with this test according to the guidelines.

  10 minutes

Secondary Outcomes (6)

• Pulmonary function test

  5 minutes

• Respiratory strength test

  10 minutes

• Physical activity measurement

  3 days

• Dyspnea scale

  1 minute

• Quality of life scale

  2 minutes

Study Arms (2)

Group 1: Patients with lung cancer

Exercise capacity \[6-minute walk test (6-MWT)\], pulmonary functions \[spirometry\], respiratory \[maximal inspiratory and expiratory pressures (MIP-MEP), mouth pressure device\] and peripheral muscle strength \[dynamometer\], physical activity level \[metabolic holter\], dyspnea \[Modified Medical Research Council dyspnea scale (MMRC)\] and quality of life \[European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTCQOL)\] were evaluated in patients with lung cancer. Vital signs, dyspnea and fatigue perception \[Modified Borg Scale\] were recorded as pre-post measurements of 6-MWT.

Group 2: Healthy individuals

Healthy individuals were selected from individuals without known and diagnosed any chronic diseases. Similar measurements were performed in healthy individuals.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Twenty six patients with lung cancer and 21 healthy individuals were included in this study. All patients were referred from Gazi University, Faculty of Medicine, Department of Thoracic Surgery to Gazi University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation. The patients with lung cancer who were decided to undergo lung surgery by thoracic surgeons were referred to the physiotherapist. Healthy volunteers were also recruited. Then, the patients were matched with healthy individuals according to statistically similarity of both age and gender.

You may qualify if:

• being between ages of 18 and 80,
• being a candidate for lung surgery due to lung cancer diagnosis,
• being able to walk,
• receiving optimal medical therapy.

You may not qualify if:

• having health problems such as cooperation,
• having orthopedic or neurological disease that limit the walking ability and physical activity,
• having comorbidities such as uncontrolled diabetes mellitus, heart failure, atrial fibrillation and/or hypertension, acute infections,
• having myocardial infarction in the last six months.
• being 18-80 years of age,
• willing to participate to the study,
• being individuals without known and diagnosed any chronic diseases.
• being current smokers,
• being ex-smokers (≥10 pack\*years).

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University Faculty of Health Science Department of Physiotherapy and Rehabilitation

Ankara, 06010, Turkey (Türkiye)

Location

Related Publications (15)

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  PMID: 26342839 RESULT

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  PMID: 9631365 RESULT

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  PMID: 24360323 RESULT

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  PMID: 1914100 RESULT

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  PMID: 18678625 RESULT

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  PMID: 11157613 RESULT

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  PMID: 25749346 RESULT

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MeSH Terms

Conditions

Lung Neoplasms; Motor Activity

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases; Behavior

Study Officials

• Gülşah Barğı, PhD

  İzmir Democracy University

  STUDY CHAIR

• Ece Baytok, MsC

  Gazi University

  STUDY CHAIR

• Zeliha Çelik, MsC

  Gazi University

  STUDY CHAIR

• Merve Şatır Türk, MD

  Gazi University

  STUDY CHAIR

• Ali Çelik, Prof. Dr.

  Gazi University

  STUDY CHAIR

• İsmail Cüneyt Kurul, Prof. Dr.

  Gazi University

  STUDY CHAIR

• Meral Boşnak Güçlü, Prof. Dr.

  Gazi University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: June 1, 2020
• First Posted: June 29, 2020
• Study Start: July 10, 2018
• Primary Completion: June 17, 2019
• Study Completion: July 26, 2019
• Last Updated: June 29, 2020

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)