Meta-Analysis on Damage Control Surgery in Patients With Non-Traumatic Abdominal Emergencies

NCT04448912 | Completed

• 1 other identifier: SRMA non-trauma DCS
• Study Type: observational
• Target: 2,170
• Locations: 1 country
• Sites: 1

Brief Summary

This systematic review and meta-analysis aims to investigate the effect of damage-control surgery on mortality in patients with non-traumatic abdominal emergencies. Literature search will be conducted using PubMed. Two meta-analyses will be performed comparing (1) mortality in patients with non-trauma damage control surgery vs. non-trauma conventional surgery and (2) the observed vs. expected mortality rate in patients undergoing non-trauma damage-control surgery.

Conditions

Damage Control Surgery; Non-traumatic Abdominal Emergencies

Outcome Measures

Primary Outcomes (1)

• Mortality

  Death after surgery for non-traumatic abdominal emergencies

  From hospital admission to discharge, expected to be up to 4 weeks

Study Arms (2)

Non-trauma damge control surgery

Patients with non-traumatic abdominal emergencies undergoing damage control surgery.

Procedure: Damage control surgery

Non-trauma conventional surgery

Patients with non-traumatic abdominal emergencies undergoing conventional surgery with primary abdominal closure.

Procedure: Conventional surgery

Interventions

Damage control surgery PROCEDURE

Surgery for non-traumatic abdominal emergencies using the damage control approach

Non-trauma damge control surgery

Conventional surgery PROCEDURE

Conventional surgery for non-traumatic abdominal emergencies

Non-trauma conventional surgery

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients undergoing surgery for non-traumatic abdominal emergencies.

You may qualify if:

• Articles on damage control surgery in patients with non-traumatic abdominal emergencies
• Reported in-hospital or 30-day mortality in patients undergoing non-trauma damage control surgery vs non-trauma conventional surgery or
• Reported observed in-hospital or 30-day mortality vs expected mortality in patients undergoing non-trauma damage control surgery
• Articles published from 2000 to 2020
• Articles including patients older than 18 years
• Original research articles
• Articles in English language

You may not qualify if:

• Articles describing trauma patients exclusively
• Articles describing pediatric patients (age below or equal to 18 years)

Sponsors & Collaborators

• Insel Gruppe AG, University Hospital Bern: lead

Study Sites (1)

Inselspital, Bern University Hospial

Bern, 3010, Switzerland

Location

Related Publications (1)

• Haltmeier T, Falke M, Quaile O, Candinas D, Schnuriger B. Damage-control surgery in patients with nontraumatic abdominal emergencies: A systematic review and meta-analysis. J Trauma Acute Care Surg. 2022 Jun 1;92(6):1075-1085. doi: 10.1097/TA.0000000000003488. Epub 2021 Dec 9.

  PMID: 34882591 DERIVED

Study Officials

• Tobias Haltmeier, MD

  Inselspital, Bern University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 23, 2020
• First Posted: June 26, 2020
• Study Start: April 30, 2018
• Primary Completion: April 24, 2021
• Study Completion: April 24, 2021
• Last Updated: November 14, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

CH (1)