EIT in Patient Ventilator Asynchrony

NCT04442815 | Completed

• 1 other identifier: EIT and ARF
• Study Type: observational
• Target: 32
• Locations: 1 country
• Sites: 1

Brief Summary

Patient-ventilator asynchrony is an important clinical issue in mechanically ventilated patients. For patients with moderate to severe acute respiratory distress syndrome (ARDS), various types of patient ventilator asynchrony may lead to injury of the lung. For example, double cycling may lead to high tidal volume and pendelluft may result in transient overstretch of dependent lung region. In this project, the investigators will record and analyze various types of patient-ventilator asynchrony in ARDS patients and analyze the regional distribution of lung gas and determined their harmful effect via concomitant recording of EIT and transpulmonary pressure. The results may influence our ventilator management of ARDS patients.

Conditions

ARDS, Human

Keywords

ARDS, patient-ventilator interaction, EIT

Outcome Measures

Primary Outcomes (2)

• Patient ventilator asynchrony

  Various types of patient ventilator asynchrony

  up to 1 hour following interruption of muscle relaxant

• Regional ventilation distribution by EIT

  Regional ventilation distribution by EIT in various types of patient ventilator asynchrony

  up to 1 hour following interruption of muscle relaxant

Secondary Outcomes (1)

• hospitalization day and final outcome

  up to 3 months

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: all genders except pregnant woman
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

moderate to severe ARDS patients

You may qualify if:

• Clinical diagnosis of moderate to severe ARDS

You may not qualify if:

• Severe chronic obstructive pulmonary diseases
• Proved barotrauma (including pneumothorax or pneumomediastinum etc.);
• Pregnancy
• Diseases characterized with increased intracranial pressure
• Patients or family who refused the informed consent.

Sponsors & Collaborators

• National Cheng-Kung University Hospital: lead

Study Sites (1)

Chang-Wen Chen

Tainan, 704, Taiwan

Location

MeSH Terms

Conditions

Respiratory Distress Syndrome

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders

Study Officials

• Chang-Wen Chen, MD

  National Cheng-Kung University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor and attending physician

Study Record Dates

• First Submitted: June 18, 2020
• First Posted: June 23, 2020
• Study Start: December 13, 2019
• Primary Completion: January 31, 2021
• Study Completion: May 31, 2021
• Last Updated: December 27, 2022

Record last verified: 2022-12

Locations

TW (1)