Relationship Between Endoplasmic Reticulum Stress and Pain in Patients With Endometriosis

NCT04440397 | Completed

• 1 other identifier: xbpendo
• Study Type: observational
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.

Conditions

Endometriosis; Endoplasmic Reticulum Stress; Endometriosis-related Pain

Outcome Measures

Primary Outcomes (1)

• Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis.

  5 months

Secondary Outcomes (1)

• serum XBP-1levels in patients wit endometriosis

  5 months

Interventions

xbp-1 - endometriosis patients group OTHER

Patients diagnosed with endometriosis by surgery and ultrasound and whose xbp-1 level was examined

Eligibility Criteria

• Age: 18 Years - 50 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Women between the ages of 18-50 who were diagnosed with endometriosis by ultrasound or surgery and who did not have any rheumatological and metaboli disease were included in the study. women with drug use indicated in the last 3 months were excluded from the study.

You may qualify if:

• diagnosed endometriosis with ultrasound or surgery
• no metabolic diseases
• no rheumatological diseases

You may not qualify if:

• Immune modulator, hormonal, anti-inflammatory use history in the last 3 months

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

Pinar Yalcin Bahat

Istanbul, İ̇stanbul, 34000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Endometriosis

Condition Hierarchy (Ancestors)

Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 17, 2020
• First Posted: June 19, 2020
• Study Start: March 17, 2020
• Primary Completion: August 1, 2020
• Study Completion: August 4, 2020
• Last Updated: August 7, 2020

Record last verified: 2020-08

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)