Epicardial Fat Thickness and Inflammation in People With Metabolic Syndrome and Obesity

NCT04437979 | Completed

• 1 other identifier: 2019-397
• Study Type: observational
• Target: 104
• Locations: 1 country
• Sites: 1

Brief Summary

Epicardial adipose tissue (EAT) is a type of visceral adipose tissue (VAT), functioning as a metabolically active endocrine organ and suggested to play an important role in the progression of metabolic syndrome (MetS). Obesity and MetS are commonly associated with an inflammatory status. The aim of the study was to evaluate the association of echocardiographically measured epicardial fat thickness (EFT) and inflammation, on the basis of c-reactive protein (CRP) and neutrophil-lymphocyte ratio (NLR), with MetS and its components in people with obesity. A total of 104 patients with body mass index (BMI)≥30 kg/m² were enrolled to the study. In all participants, EFT was measured with transthoracic echocardiography at end-systole. The patients were then classified into two groups according to whether they had MetS or not. EFT, clinical and biochemical parameters were compared between the two groups

Conditions

Metabolic Syndrome; Obesity; Inflammation

Keywords

epicardial fat thickness; metabolic syndrome; obesity

Outcome Measures

Primary Outcomes (1)

• Estimation of the epicardial fat thickness in the presence of metabolic syndrome in people with obesity

  Transthoracic echocardiography was performed to all participants with body mass index \> 30 kg/m2 and epicardial fat thickness was measured. Epicardial fat thickness (EFT) was identified as the echo-free space in the pericardial layers on 2D echocardiography. EFT was measured on the free wall of the right ventricle at end-systole from both parasternal long axis and parasternal short axis views using the mean of three consecutive beats The patients were classified into two groups according to whether they had MetS or not. MetS was diagnosed according to the National Cholesterol Education Programme Adult Treatment Panel III. We evaluated the difference in epicardial fat thickness according to whether having metabolic syndrome or not, regardless of body mass index.

  1 week

Secondary Outcomes (1)

• Estimation of inflammation in the presence of metabolic syndrome in people with obesity

  1 week

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with BMI ≥30 kg/m2, \>18 years old and without manifest heart disease such as, coronary heart disease, cardiac failure, cardiac valve disease or arrythmia, renal failure, hepatic failure, infection, chronic systemic inflammatory disease, pulmonary disease and malignancy

You may qualify if:

• \- Having body mass index ≥30 kg/m2

You may not qualify if:

• Manifest heart disease ( coronary heart disease, cardiac failure, cardiac valve disease or arrythmia)
• Renal failure
• Hepatic failure
• Infection
• Chronic systemic inflammatory disease
• Pulmonary disease
• Malignancy
• Inadequate transthoracic echocardiographic images

Sponsors & Collaborators

• Antalya Training and Research Hospital: lead

Study Sites (1)

Antalya Research and Training Hospital

Antalya, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Metabolic Syndrome; Obesity; Inflammation

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Study Officials

• Duygu Ersan Demirci, MD

  Antalya Research and Training Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: June 16, 2020
• First Posted: June 18, 2020
• Study Start: January 1, 2019
• Primary Completion: July 1, 2019
• Study Completion: September 1, 2019
• Last Updated: August 21, 2020

Record last verified: 2020-08

Locations

TU (1)