Effects of Hydrolyzed Collagen and Vitamin C on Explosive Performance

NCT04437758 | Completed DMC

• 1 other identifier: PEP-1704
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Determine whether supplementation with a combined dose of 20 g of hydrolyzed collagen and 50 mg vitamin C, along with a power training exercise program, increases rate of force development (RFD) and performance in athletes

Conditions

Collagen Synthesis; Rate of Force (RFD) Development

Keywords

exercise; performance; athletes

Outcome Measures

Primary Outcomes (3)

• Maximal rate of force development (RFD) of isometric squat (MIS)

  Force (N) over time (msec) for the maximum slope of the first 20% of the movement

  % change from baseline to week 1, week 2 and week 3

• Counter-movement jump (CMJ) rate of force development (RFD)

  CMJ jump performance N/s/kg

  % change from baseline to week 1, week 2 and week 3

• Squat jump height rate of force development (RFD)

  Squat jump height performance RFD/kg

  % change from baseline to week 1, week 2 and week 3

Other Outcomes (4)

• Maximum peak force of maximal isometric squat (MIS)

  % change from baseline to week 1, week 2 and week 3

• Counter-movement jump (CMJ) net eccentric impulse

  % change from baseline to week 1, week 2 and week 3

• Counter-movement jump (CMJ) net concentric impulse

  % change from baseline to week 1, week 2 and week 3

Study Arms (2)

Hydrolyzed collagen and Vitamin C powder mix

EXPERIMENTAL

20 g hydrolyzed collagen + 50 mg vitamin C (ascorbic acid) pre-packed powder diluted in 250 ml (8 oz) of water

Dietary Supplement: Collagen and Vitamin C powder mix nutritional intervention; Other: Maximum power training exercise

Maltodextrin powder

PLACEBO COMPARATOR

20 g maltodextrin pre-packed powder diluted in 250 ml (8 oz) of water

Other: Maltodextrin placebo powder; Other: Maximum power training exercise

Interventions

Collagen and Vitamin C powder mix nutritional intervention DIETARY_SUPPLEMENT

20 g collagen + 50 mg vitamin C daily, 60 min prior to exercise

Hydrolyzed collagen and Vitamin C powder mix

Maltodextrin placebo powder OTHER

20 g maltodextrin placebo daily, 60 min prior to exercise

Maltodextrin powder

Maximum power training exercise OTHER

Explosive/power-based exercise training program 3 times/week at home consisting of drop jumps, box jumps, weighted jump squats loaded in a progressive manner weekly for 3 weeks. At baseline and at the end of each of the 3 weeks, measures of explosive performance are assessed in the lab (maximal isometric squat, counter-movement jump and squat jump)

Hydrolyzed collagen and Vitamin C powder mix; Maltodextrin powder

Eligibility Criteria

• Age: 18 Years - 30 Years
• Gender Eligibility Details: Collagen synthesis varies significantly throughout the menstrual cycle in females. This natural variation would confound the study. Provided this work proves successful, we will aim to perform similar studies in females.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male athletes between 18-30 years of age
• Currently participating in sport
• \<3 musculoskeletal injuries in the past year
• No health or dietary restriction that would be affected by the supplementation protocol

You may not qualify if:

• History of more than 3 musculoskeletal injuries within the past 12 months
• Health, dietary restriction or diet that would be affected by the supplementation protocol
• Willing to eat similar dietary pattern the day before baseline testing and each exercise testing/intervention day

Sponsors & Collaborators

• PepsiCo Global R&D: lead

Study Sites (1)

UC Davis Functional Molecular Biology Laboratory and Human Performance Laboratory

Davis, California, 95616, United States

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Collagen

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Biopolymers; Polymers; Macromolecular Substances; Extracellular Matrix Proteins; Scleroproteins; Proteins; Amino Acids, Peptides, and Proteins

Study Officials

• Keith Baar, PhD

  University of California, Davis

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Sealed opaque packets coded by Sponsor's Product Development
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 12, 2020
• First Posted: June 18, 2020
• Study Start: August 22, 2019
• Primary Completion: February 5, 2020
• Study Completion: February 5, 2020
• Last Updated: June 18, 2020

Record last verified: 2020-06

Locations

US (1)