COVID19 Versus H1N1: Radiological Challenge During Next Influenza Season Rising

NCT04433039 | Completed

• 1 other identifier: IRB (00012098), SN (0304669)
• Study Type: observational
• Target: 130
• Locations: 1 country
• Sites: 1

Brief Summary

Background: Till the moment of editing this paperwork, WHO announced that there is no specific drugs or vaccines for treatment or prophylaxis of COVID-19. Additionally during the global gradual unlocking of community restrictions, WHO warned form another wave of the disease during the next few months. So clinicians and radiologists during this second wave would face great challenges in differentiation between COVID-19 and other virulent influenza viruses, mainly H1N1. Objective: to establish comparative radiological study between COVID19 and H1N1 to find differentiating criteria that would help during their expected clinico-laboratory and radiological overlap in next Influenza season. Material and methods: Retrospective study was including 130 patients; 65 COVID-19 patients and 65 H1N1 patients. HRCT findings to be analyzed by three expert consultant radiologists.

Conditions

COVID

Outcome Measures

Primary Outcomes (1)

• COVID19 versus H1N1; radiological comparative study

  Find HRCT differences between COVID-19 and H1N1

  "through study completion, an average of 20 days"

Eligibility Criteria

• Age: 4 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

130 patients; 65 patients known with COVID19 (registered during the period from February till May 2020) and 65 patients known with H1N1 (registered during the period from January 2010 till January 2020).

You may qualify if:

• Patients with COVID-19 or H1N1

You may not qualify if:

• (1) Degraded quality of CT scans due to patient unavoidable tachypnea with respiratory motion artifacts. (2) Unremarkable CT scans were also excluded. (3) Past history of large airway disease, asthma, COPD or bronchiectasis. (4) Patients with secondary bacterial infection.

Sponsors & Collaborators

• Alexandria University: lead

Study Sites (1)

Faculty of Medicine, University of Alexandria

Alexandria, 21526, Egypt

Location

Study Officials

• Ahmed Samir, MD

  Department of Radio-diagnosis.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of radio-diagnosis

Study Record Dates

• First Submitted: June 14, 2020
• First Posted: June 16, 2020
• Study Start: May 22, 2020
• Primary Completion: June 12, 2020
• Study Completion: June 14, 2020
• Last Updated: June 16, 2020

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)