NCT04428112

Brief Summary

Rural caregivers face challenges of geographic isolation and lower health care access and quality. Many rural dementia caregivers experience serious health consequences due to caregiving responsibilities that can limit their ability to maintain their caregiving role. Thus, there is a pressing need for effective, scalable, and accessible programs to support rural dementia caregivers. Online programs offer a convenient and readily translatable option for program delivery because they can be accessed by caregivers in the home and at the convenience of the user. Building Better Caregivers is an online 6-week, interactive, small-group self-management, social support, and skills-building workshop developed for caregivers of individuals with Alzheimer's disease or related dementia. The investigators will conduct a hybrid effectiveness-implementation randomized controlled trial that will enroll and randomize 640 rural dementia caregivers into two groups: the intervention (workshop) group and the attention control group. Caregivers will be recruited throughout the United States. Primary outcomes will be caregiver stress and depressive symptoms. The investigators hypothesize that stress scores and depressive symptoms will be significantly improved at 12 months in the intervention group versus control group. The investigators will also identify key strengths (facilitators) and weaknesses (barriers) of workshop implementation. The investigators will use the RE-AIM implementation framework and a mixed methods approach to identify implementation characteristics pertinent to both caregivers and rural community organizations. If the Building Better Caregivers workshop is proven to be effective, this research has the potential to open new research horizons, particularly on how to reach and effectively support isolated dementia caregivers in rural areas with an intervention that is scalable, even in low-resourced settings. If the workshop can achieve its goals with rural dementia caregivers, some of those most isolated, it would also be expected to be scalable in other low-resourced settings (e.g., in urban or suburban environments).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
418

participants targeted

Target at P75+ for not_applicable depression

Timeline
Completed

Started Jun 2020

Typical duration for not_applicable depression

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 5, 2020

Completed
4 days until next milestone

First Submitted

Initial submission to the registry

June 9, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 11, 2020

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 16, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 16, 2023

Completed
1.8 years until next milestone

Results Posted

Study results publicly available

July 17, 2025

Completed
Last Updated

July 17, 2025

Status Verified

June 1, 2025

Enrollment Period

3.4 years

First QC Date

June 9, 2020

Results QC Date

December 3, 2024

Last Update Submit

June 27, 2025

Conditions

Keywords

CaregiverCaregiving

Outcome Measures

Primary Outcomes (2)

  • Personal Health Questionnaire Depression (PHQ-8) Scale Score

    Personal Health Questionnaire Depression (PHQ-8) scale. The scale score is calculated by summing each item to produce a total score between 0 and 24, with higher scores indicating worse outcome.

    12 months

  • Visual Numeric Stress Scale

    A visual numeric stress scale. The scale score ranges from 0 to 10, with higher score indicating worse outcome.

    12 months

Secondary Outcomes (9)

  • Personal Health Questionnaire Depression (PHQ-8) Scale Score

    6 months

  • Visual Numeric Stress Scale Score

    6 months

  • Short Caregiver Self-Efficacy Scale Score

    12 months

  • Zarit Burden Interview-12 (ZBI-12) Scale Score

    12 months

  • Caregiver Self-rated General Health Score

    12 months

  • +4 more secondary outcomes

Study Arms (2)

Building Better Caregivers Workshop Group

EXPERIMENTAL

Building Better Caregivers Workshop is a 6-week online self-management and skills building workshop. Participants receive the online workshop as soon as possible after randomization.

Behavioral: Building Better Caregivers Workshop

Attention Control Group

ACTIVE COMPARATOR

Participants will be offered the online workshop after the 12 month trial is completed if they so desire.

Behavioral: Attention Control

Interventions

Workshops consist of small group or about 20-25 persons. Two peer co-facilitators (caregiver themselves) will guide workshop activities. Participants will receive a workshop booklet. Each week, participants will log on at least 2-3 times for a total time of approximately two hours. Participants do not require "real time" attendance at pre-determined times.

Building Better Caregivers Workshop Group

Participants will receive two brief 15-30 minutes phone calls by study staff, and will receive a handbook on dementia and caregiver resources while they wait for the workshop.

Attention Control Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Aged 18 years or older
  • Caring for person with dementia
  • Able to read and write in English
  • Able to access the internet
  • Providing care for ≥ 10 hours per week
  • Reporting a minimum stress level of 4 or more on a 10-point scale
  • Living in rural area of United States (self-identify or zip code is a Rural Urban Commuting Area Codes (RUCA) defined rural area)

You may not qualify if:

  • Have an anticipated inability to complete the 12-month follow-up (e.g., planned travel)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of California, San Francisco

San Francisco, California, 94118, United States

Location

Related Publications (3)

  • Santoyo-Olsson J, Covinsky KE, Cheng J, Gallagher Thompson D, Yank V. Utilization of home- and community-based services among rural family caregivers of persons with dementia: the role of the area deprivation index. Front Public Health. 2025 Oct 14;13:1688161. doi: 10.3389/fpubh.2025.1688161. eCollection 2025.

  • Santoyo-Olsson J, Covinsky KE, Chesla CA, Lorig K, Gallagher-Thompson D, Cheng J, Luzanilla M, Macias Romo E, Aguayo Ramirez G, Karliner L, Yank V. Predictors of Psychological Distress Among Rural Family/Friend Caregivers of People Living With Dementia in the United States: Consequences of the COVID-19 Pandemic. J Gerontol B Psychol Sci Soc Sci. 2024 Feb 1;79(2):gbad164. doi: 10.1093/geronb/gbad164.

  • Santoyo-Olsson J, Lorig K, Romo EM, Luzanilla M, Ramirez GA, Cheng J, Chesla C, Covinsky KE, Karliner L, Thompson DG, Fahrenwald N, Yank V. Study protocol for a hybrid effectiveness-implementation trial of the Building Better Caregivers online workshop for rural family/friend caregivers of people living with dementia. Contemp Clin Trials. 2022 Oct;121:106903. doi: 10.1016/j.cct.2022.106903. Epub 2022 Aug 31.

MeSH Terms

Conditions

DepressionStress, PsychologicalSocial IsolationPatient Acceptance of Health CareDementiaAlzheimer DiseaseDementia, VascularLewy Body DiseaseMixed DementiasAIDS Dementia ComplexPick Disease of the BrainDementia, Multi-Infarct

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorSocial BehaviorTreatment Adherence and ComplianceHealth BehaviorBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental DisordersTauopathiesNeurodegenerative DiseasesCerebrovascular DisordersIntracranial ArteriosclerosisIntracranial Arterial DiseasesLeukoencephalopathiesArteriosclerosisArterial Occlusive DiseasesVascular DiseasesCardiovascular DiseasesParkinsonian DisordersBasal Ganglia DiseasesMovement DisordersSynucleinopathiesHIV InfectionsBlood-Borne InfectionsCommunicable DiseasesInfectionsSexually Transmitted Diseases, ViralSexually Transmitted DiseasesLentivirus InfectionsRetroviridae InfectionsRNA Virus InfectionsVirus DiseasesGenital DiseasesUrogenital DiseasesImmunologic Deficiency SyndromesImmune System DiseasesFrontotemporal DementiaFrontotemporal Lobar DegenerationCerebral InfarctionBrain InfarctionBrain IschemiaStrokeInfarctionIschemiaPathologic ProcessesPathological Conditions, Signs and SymptomsNecrosis

Limitations and Caveats

Randomization occurred 2 weeks before group delivery to allow for mailing of books and scheduling calls. During this run-in period 9 participants were administratively dropped: 4 in intervention group, due to death of person with dementia (2), being a duplicate (1), and inability to verify identity (1); 5 in control group, due to death of their person (3), death of caregiver in natural disaster (1), and being paid caregiver (1). Thus, the modified ITT analysis included 409 participants.

Results Point of Contact

Title
Dr. Veronica Yank
Organization
UCSF

Study Officials

  • Veronica Yank, MD

    University of California, San Francisco

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 9, 2020

First Posted

June 11, 2020

Study Start

June 5, 2020

Primary Completion

October 16, 2023

Study Completion

October 16, 2023

Last Updated

July 17, 2025

Results First Posted

July 17, 2025

Record last verified: 2025-06

Data Sharing

IPD Sharing
Will share

The data to be shared will be individual participant data that underlie the results reported in published article(s), after deidentification (e.g., text, tables, figures, and appendices). The additional and related documents that will be available are study protocol and data dictionary. The data will become available beginning within 3 months of article publication and ending 5 years following article publication.The access criteria for the data to be shared will include researchers who provide a methodologically sound proposal in order to achieve aims in the approved proposal including performance of meta-analysis of individual participant data. Proposals should be directed to veronica.yank@ucsf.edu. To gain access, data requestors will need to sign a data access agreement. Data will be available for 5 years at a third party website (Link to be included later).

Shared Documents
STUDY PROTOCOL
Time Frame
The data will become available beginning within 3 months of article publication and ending 5 years following article publication.
Access Criteria
The access criteria for the data to be shared will include researchers who provide a methodologically sound proposal in order to achieve aims in the approved proposal including performance of meta-analysis of individual participant data. Proposals should be directed to veronica.yank@ucsf.edu. To gain access, data requestors will need to sign a data access agreement. Data will be available for 5 years at a third party website (Link to be included later).

Locations