RT-PCR SARS-CoV-2 at 1 Month of COVID-19 Infection in the Geriatric Population

NCT04427358 | Completed

• 1 other identifier: 7838
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Evaluation of the rate of positive RT-PCR SARS-CoV-2 test at 1 month of COVID infection among elderly people. It is unclear how long an individual with COVID-19 will remain "sick" and "contagious". It appears that SARS-CoV-2 can be transmitted before symptoms appear and throughout the course of the disease. They investigators did not find any study on a COVID + geriatric population reassessing carriage at 1 month even though age seems to be a risk factor for prolonged excretion as suggested in the study following study: Xu K, Chen Y, Yuan J, Yi P, Ding C, Wu W, et al. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clinical Infectious Diseases. 2020 Apr 9; ciaa351

Conditions

Covid-19

Keywords

RT-PCR SARS-CoV-2; Covid-19; Carriage; Viral shredding; Elderly; Elderly people; Geriatric

Outcome Measures

Primary Outcomes (2)

• 1. Analysis of the rate of RT-PCR SARS-CoV-2 positive at 1 month of COVID infection

  at 1 month of COVID infection]

• 2. Assess quantitative evaluation of a nasopharyngeal swab SARS-CoV-2 RT-PCR test

  The objective of this study is to quantitatively assess viral shedding in COVID-19 infected elderly patients who survived infection in order to provide an overview of the evolution of nasopharyngeal swab SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test results with the Cycle threshold value of the RT-PCR test.. The investigatrors analyze nasopharyngeal RT-PCR at diagnosis. After one month since the date of onset symptoms they reassessed survival patients with nasopharyngeal RT-PCR and repeat the RT-PCR at least every week until final negative conversion occurs.

  at 1 month after COVID infection

Secondary Outcomes (1)

• Assessment of late stool SARS-CoV-2 RT-PCR, serological status and associated factors with death and RT-PCR results 1 month after the date of first symptom onset

  1 month after the date of first symptom onset

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patient over 70 years age having COVID-19

You may qualify if:

• Age\> 70years
• Patient hospitalized on the geriatric center from March 1, 2020 to August 1, 2020 with a diagnosis of COVID-19 still alive at 1 month.
• Patient having agreed to the re-use of their data for the purposes of this research

You may not qualify if:

• Subject who expressed his opposition to participate in the study
• Subject under judicial protection

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service SSR Gériatrique

Strasbourg, 67091, France

Location

MeSH Terms

Conditions

COVID-19

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2020
• First Posted: June 11, 2020
• Study Start: May 7, 2020
• Primary Completion: August 7, 2020
• Study Completion: September 7, 2020
• Last Updated: November 25, 2020

Record last verified: 2020-06

Locations

FR (1)